HOMER3

 

Full name: homer scaffold protein 3 Alias Symbol: HOMER-3
Type: protein-coding gene Cytoband: 19p13.11
Entrez ID: 9454 HGNC ID: HGNC:17514 Ensembl Gene: ENSG00000051128 OMIM ID: 604800
Drug and gene relationship at DGIdb

 

HOMER3 involved pathways:

KEGG pathway Description View
hsa04068FoxO signaling pathway
hsa04724Glutamatergic synapse

 

Expression of HOMER3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 HOMER3 9454 204647_at 1.5506 0.0107
GSE20347 HOMER3 9454 215489_x_at 1.0891 0.0000
GSE23400 HOMER3 9454 215489_x_at 1.0692 0.0000
GSE26886 HOMER3 9454 204647_at 3.0154 0.0000
GSE29001 HOMER3 9454 204647_at 2.3550 0.0011
GSE38129 HOMER3 9454 204647_at 1.6472 0.0000
GSE45670 HOMER3 9454 204647_at 1.5490 0.0001
GSE53622 HOMER3 9454 100098 0.6996 0.0000
GSE53624 HOMER3 9454 37334 2.1105 0.0000
GSE63941 HOMER3 9454 204647_at -1.6203 0.0168
GSE77861 HOMER3 9454 215489_x_at 1.1755 0.0006
GSE97050 HOMER3 9454 A_33_P3265374 0.8688 0.1670
SRP007169 HOMER3 9454 RNAseq 2.6064 0.0022
SRP008496 HOMER3 9454 RNAseq 2.5926 0.0001
SRP064894 HOMER3 9454 RNAseq 2.9311 0.0000
SRP133303 HOMER3 9454 RNAseq 1.7282 0.0000
SRP159526 HOMER3 9454 RNAseq 1.8798 0.0000
SRP193095 HOMER3 9454 RNAseq 2.3435 0.0000
SRP219564 HOMER3 9454 RNAseq 1.7934 0.0002
TCGA HOMER3 9454 RNAseq 0.6599 0.0000

Upregulated datasets: 16; Downregulated datasets: 1.  

 

Survival by HOMER3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of HOMER3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 HOMER3 9454 4 5 21
GSE20123 HOMER3 9454 3 3 24
GSE43470 HOMER3 9454 2 5 36
GSE46452 HOMER3 9454 47 1 11
GSE47630 HOMER3 9454 5 8 27
GSE54993 HOMER3 9454 16 4 50
GSE54994 HOMER3 9454 6 13 34
GSE60625 HOMER3 9454 9 0 2
GSE74703 HOMER3 9454 2 3 31
GSE74704 HOMER3 9454 0 3 17
TCGA HOMER3 9454 16 10 70

Total number of gains: 110; Total number of losses: 55; Total Number of normals: 323.  

 

Somatic mutations of HOMER3:

 

Generating mutation plots.

 

Highly correlated genes for HOMER3:

 

Showing top 20/1092 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
HOMER3USB10.79605411011
HOMER3COLGALT10.79490511011
HOMER3XPR10.793599606
HOMER3SERPINH10.7897911011
HOMER3TMEM184B0.78709311011
HOMER3TGFBI0.78181711011
HOMER3SCYL10.776744404
HOMER3MFAP20.77265611010
HOMER3FMNL20.77128706
HOMER3WDR540.766987606
HOMER3ARPC1B0.76489111011
HOMER3MRGBP0.76488810010
HOMER3NTMT10.757329606
HOMER3PLAU0.75370612010
HOMER3CDC25B0.75235810010
HOMER3PMEPA10.7492611011
HOMER3TTYH30.748312707
HOMER3COL7A10.74421611011
HOMER3LAMC20.74369512011
HOMER3INHBA0.74251312010

For details and further investigation, click here