| Full name: phosphatidylinositol 4-kinase type 2 alpha | Alias Symbol: PI4KII|DKFZP761G1923|PIK42A | ||
| Type: protein-coding gene | Cytoband: 10q24.2 | ||
| Entrez ID: 55361 | HGNC ID: HGNC:30031 | Ensembl Gene: ENSG00000155252 | OMIM ID: 609763 |
| Drug and gene relationship at DGIdb | |||
Expression of PI4K2A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PI4K2A | 55361 | 209345_s_at | 0.1239 | 0.6775 | |
| GSE20347 | PI4K2A | 55361 | 209345_s_at | -0.3171 | 0.0519 | |
| GSE23400 | PI4K2A | 55361 | 209345_s_at | -0.3009 | 0.0001 | |
| GSE26886 | PI4K2A | 55361 | 209345_s_at | -1.0540 | 0.0005 | |
| GSE29001 | PI4K2A | 55361 | 209345_s_at | -0.7170 | 0.0030 | |
| GSE38129 | PI4K2A | 55361 | 209345_s_at | -0.2337 | 0.0563 | |
| GSE45670 | PI4K2A | 55361 | 209345_s_at | -0.0604 | 0.7744 | |
| GSE53622 | PI4K2A | 55361 | 113833 | -0.4124 | 0.0008 | |
| GSE53624 | PI4K2A | 55361 | 113833 | -0.6124 | 0.0000 | |
| GSE63941 | PI4K2A | 55361 | 209345_s_at | -0.9621 | 0.0340 | |
| GSE77861 | PI4K2A | 55361 | 209345_s_at | -0.2878 | 0.1617 | |
| GSE97050 | PI4K2A | 55361 | A_24_P244162 | 0.0029 | 0.9933 | |
| SRP007169 | PI4K2A | 55361 | RNAseq | -1.8632 | 0.0000 | |
| SRP008496 | PI4K2A | 55361 | RNAseq | -1.7179 | 0.0000 | |
| SRP064894 | PI4K2A | 55361 | RNAseq | -0.6607 | 0.0002 | |
| SRP133303 | PI4K2A | 55361 | RNAseq | -0.3722 | 0.0478 | |
| SRP159526 | PI4K2A | 55361 | RNAseq | -0.4441 | 0.1372 | |
| SRP193095 | PI4K2A | 55361 | RNAseq | -0.8353 | 0.0001 | |
| SRP219564 | PI4K2A | 55361 | RNAseq | -0.5917 | 0.0747 | |
| TCGA | PI4K2A | 55361 | RNAseq | 0.0748 | 0.1546 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by PI4K2A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PI4K2A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PI4K2A | 55361 | 1 | 8 | 21 | |
| GSE20123 | PI4K2A | 55361 | 1 | 7 | 22 | |
| GSE43470 | PI4K2A | 55361 | 0 | 7 | 36 | |
| GSE46452 | PI4K2A | 55361 | 0 | 11 | 48 | |
| GSE47630 | PI4K2A | 55361 | 2 | 14 | 24 | |
| GSE54993 | PI4K2A | 55361 | 8 | 0 | 62 | |
| GSE54994 | PI4K2A | 55361 | 2 | 11 | 40 | |
| GSE60625 | PI4K2A | 55361 | 0 | 0 | 11 | |
| GSE74703 | PI4K2A | 55361 | 0 | 5 | 31 | |
| GSE74704 | PI4K2A | 55361 | 0 | 4 | 16 | |
| TCGA | PI4K2A | 55361 | 5 | 28 | 63 |
Total number of gains: 19; Total number of losses: 95; Total Number of normals: 374.
Somatic mutations of PI4K2A:
Generating mutation plots.
Highly correlated genes for PI4K2A:
Showing top 20/793 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PI4K2A | TFIP11 | 0.826407 | 3 | 0 | 3 |
| PI4K2A | ZNF70 | 0.795175 | 3 | 0 | 3 |
| PI4K2A | COMMD5 | 0.786759 | 3 | 0 | 3 |
| PI4K2A | C16orf58 | 0.760153 | 3 | 0 | 3 |
| PI4K2A | NOC2L | 0.759248 | 3 | 0 | 3 |
| PI4K2A | SESN2 | 0.758127 | 5 | 0 | 5 |
| PI4K2A | PIP4K2C | 0.752436 | 3 | 0 | 3 |
| PI4K2A | NUP188 | 0.741607 | 3 | 0 | 3 |
| PI4K2A | MAP2K3 | 0.734945 | 3 | 0 | 3 |
| PI4K2A | TMEM117 | 0.73313 | 3 | 0 | 3 |
| PI4K2A | VCPIP1 | 0.721878 | 3 | 0 | 3 |
| PI4K2A | ADAMTSL5 | 0.721484 | 3 | 0 | 3 |
| PI4K2A | ZFC3H1 | 0.711402 | 3 | 0 | 3 |
| PI4K2A | ZNF709 | 0.709078 | 3 | 0 | 3 |
| PI4K2A | TAX1BP3 | 0.706352 | 3 | 0 | 3 |
| PI4K2A | UBA3 | 0.704403 | 3 | 0 | 3 |
| PI4K2A | CMA1 | 0.701863 | 3 | 0 | 3 |
| PI4K2A | ZNF92 | 0.700834 | 3 | 0 | 3 |
| PI4K2A | LASP1 | 0.695117 | 3 | 0 | 3 |
| PI4K2A | MVP | 0.693597 | 4 | 0 | 3 |
For details and further investigation, click here
