| Full name: sestrin 2 | Alias Symbol: SES2|DKFZp761M0212|HI95|SEST2 | ||
| Type: protein-coding gene | Cytoband: 1p35.3 | ||
| Entrez ID: 83667 | HGNC ID: HGNC:20746 | Ensembl Gene: ENSG00000130766 | OMIM ID: 607767 |
| Drug and gene relationship at DGIdb | |||
SESN2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04115 | p53 signaling pathway | |
| hsa04150 | mTOR signaling pathway | |
| hsa04211 | Longevity regulating pathway - mammal |
Expression of SESN2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SESN2 | 83667 | 223195_s_at | -0.5834 | 0.2250 | |
| GSE26886 | SESN2 | 83667 | 223195_s_at | -1.8247 | 0.0001 | |
| GSE45670 | SESN2 | 83667 | 223196_s_at | -0.1840 | 0.6153 | |
| GSE53622 | SESN2 | 83667 | 4660 | -1.3827 | 0.0000 | |
| GSE53624 | SESN2 | 83667 | 4660 | -1.4936 | 0.0000 | |
| GSE63941 | SESN2 | 83667 | 223195_s_at | 0.2141 | 0.7892 | |
| GSE77861 | SESN2 | 83667 | 223195_s_at | -0.6614 | 0.0617 | |
| GSE97050 | SESN2 | 83667 | A_23_P35082 | -0.2820 | 0.5766 | |
| SRP007169 | SESN2 | 83667 | RNAseq | -4.1231 | 0.0000 | |
| SRP008496 | SESN2 | 83667 | RNAseq | -3.9273 | 0.0000 | |
| SRP064894 | SESN2 | 83667 | RNAseq | -1.6118 | 0.0000 | |
| SRP133303 | SESN2 | 83667 | RNAseq | -1.2396 | 0.0000 | |
| SRP159526 | SESN2 | 83667 | RNAseq | -2.1511 | 0.0000 | |
| SRP193095 | SESN2 | 83667 | RNAseq | -2.2584 | 0.0000 | |
| SRP219564 | SESN2 | 83667 | RNAseq | -1.2463 | 0.0350 | |
| TCGA | SESN2 | 83667 | RNAseq | -0.1864 | 0.0358 |
Upregulated datasets: 0; Downregulated datasets: 10.
Survival by SESN2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SESN2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SESN2 | 83667 | 0 | 6 | 24 | |
| GSE20123 | SESN2 | 83667 | 0 | 5 | 25 | |
| GSE43470 | SESN2 | 83667 | 3 | 6 | 34 | |
| GSE46452 | SESN2 | 83667 | 5 | 1 | 53 | |
| GSE47630 | SESN2 | 83667 | 8 | 3 | 29 | |
| GSE54993 | SESN2 | 83667 | 2 | 1 | 67 | |
| GSE54994 | SESN2 | 83667 | 10 | 4 | 39 | |
| GSE60625 | SESN2 | 83667 | 0 | 0 | 11 | |
| GSE74703 | SESN2 | 83667 | 2 | 4 | 30 | |
| GSE74704 | SESN2 | 83667 | 0 | 0 | 20 | |
| TCGA | SESN2 | 83667 | 11 | 23 | 62 |
Total number of gains: 41; Total number of losses: 53; Total Number of normals: 394.
Somatic mutations of SESN2:
Generating mutation plots.
Highly correlated genes for SESN2:
Showing top 20/1240 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SESN2 | GYS2 | 0.780622 | 6 | 0 | 6 |
| SESN2 | TRIP10 | 0.771401 | 7 | 0 | 7 |
| SESN2 | PSCA | 0.767303 | 4 | 0 | 4 |
| SESN2 | PLCD1 | 0.767134 | 6 | 0 | 6 |
| SESN2 | VASN | 0.766252 | 7 | 0 | 7 |
| SESN2 | ANKRD37 | 0.764249 | 5 | 0 | 5 |
| SESN2 | ECM1 | 0.763222 | 6 | 0 | 6 |
| SESN2 | ZNF365 | 0.759969 | 6 | 0 | 6 |
| SESN2 | PI4K2A | 0.758127 | 5 | 0 | 5 |
| SESN2 | ABHD5 | 0.757555 | 7 | 0 | 7 |
| SESN2 | NUAK2 | 0.756796 | 3 | 0 | 3 |
| SESN2 | MXD1 | 0.748851 | 7 | 0 | 6 |
| SESN2 | ATG9B | 0.748102 | 7 | 0 | 6 |
| SESN2 | SCNN1B | 0.747988 | 6 | 0 | 6 |
| SESN2 | SYNPO2L | 0.747139 | 6 | 0 | 6 |
| SESN2 | EPG5 | 0.746431 | 5 | 0 | 5 |
| SESN2 | SPNS2 | 0.745491 | 5 | 0 | 5 |
| SESN2 | RANBP9 | 0.745147 | 7 | 0 | 7 |
| SESN2 | SFTA2 | 0.744605 | 4 | 0 | 4 |
| SESN2 | PADI1 | 0.743394 | 4 | 0 | 4 |
For details and further investigation, click here
