| Full name: spondin 1 | Alias Symbol: KIAA0762|f-spondin | ||
| Type: protein-coding gene | Cytoband: 11p15.2 | ||
| Entrez ID: 10418 | HGNC ID: HGNC:11252 | Ensembl Gene: ENSG00000262655 | OMIM ID: 604989 |
| Drug and gene relationship at DGIdb | |||
Expression of SPON1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPON1 | 10418 | 209436_at | -0.8423 | 0.3618 | |
| GSE20347 | SPON1 | 10418 | 209436_at | 0.2114 | 0.3195 | |
| GSE23400 | SPON1 | 10418 | 209436_at | 0.0523 | 0.6639 | |
| GSE26886 | SPON1 | 10418 | 209436_at | 0.7266 | 0.1496 | |
| GSE29001 | SPON1 | 10418 | 209436_at | -0.0279 | 0.9400 | |
| GSE38129 | SPON1 | 10418 | 209436_at | -0.1198 | 0.7211 | |
| GSE45670 | SPON1 | 10418 | 209436_at | -1.5441 | 0.0009 | |
| GSE53622 | SPON1 | 10418 | 8233 | -0.0502 | 0.8132 | |
| GSE53624 | SPON1 | 10418 | 8233 | -0.0368 | 0.8680 | |
| GSE63941 | SPON1 | 10418 | 209436_at | -4.4354 | 0.0000 | |
| GSE77861 | SPON1 | 10418 | 209436_at | 0.5225 | 0.3024 | |
| GSE97050 | SPON1 | 10418 | A_32_P133072 | 0.6660 | 0.1203 | |
| SRP007169 | SPON1 | 10418 | RNAseq | 1.2889 | 0.0224 | |
| SRP008496 | SPON1 | 10418 | RNAseq | 2.1178 | 0.0000 | |
| SRP064894 | SPON1 | 10418 | RNAseq | 0.8617 | 0.0336 | |
| SRP133303 | SPON1 | 10418 | RNAseq | -0.1589 | 0.6176 | |
| SRP159526 | SPON1 | 10418 | RNAseq | 0.2957 | 0.5134 | |
| SRP193095 | SPON1 | 10418 | RNAseq | 0.4503 | 0.1761 | |
| SRP219564 | SPON1 | 10418 | RNAseq | 1.4708 | 0.0471 | |
| TCGA | SPON1 | 10418 | RNAseq | -0.4507 | 0.0036 |
Upregulated datasets: 3; Downregulated datasets: 2.
Survival by SPON1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPON1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPON1 | 10418 | 1 | 10 | 19 | |
| GSE20123 | SPON1 | 10418 | 1 | 10 | 19 | |
| GSE43470 | SPON1 | 10418 | 2 | 5 | 36 | |
| GSE46452 | SPON1 | 10418 | 7 | 5 | 47 | |
| GSE47630 | SPON1 | 10418 | 3 | 11 | 26 | |
| GSE54993 | SPON1 | 10418 | 3 | 1 | 66 | |
| GSE54994 | SPON1 | 10418 | 4 | 12 | 37 | |
| GSE60625 | SPON1 | 10418 | 0 | 0 | 11 | |
| GSE74703 | SPON1 | 10418 | 2 | 3 | 31 | |
| GSE74704 | SPON1 | 10418 | 0 | 9 | 11 | |
| TCGA | SPON1 | 10418 | 12 | 32 | 52 |
Total number of gains: 35; Total number of losses: 98; Total Number of normals: 355.
Somatic mutations of SPON1:
Generating mutation plots.
Highly correlated genes for SPON1:
Showing top 20/825 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPON1 | ECSCR | 0.762879 | 6 | 0 | 6 |
| SPON1 | LINC01279 | 0.761565 | 4 | 0 | 4 |
| SPON1 | CCDC3 | 0.740858 | 4 | 0 | 4 |
| SPON1 | UNC5C | 0.725058 | 6 | 0 | 6 |
| SPON1 | PIP4K2A | 0.724267 | 5 | 0 | 5 |
| SPON1 | CNRIP1 | 0.721083 | 9 | 0 | 9 |
| SPON1 | GDF6 | 0.718007 | 3 | 0 | 3 |
| SPON1 | SMPD1 | 0.71677 | 4 | 0 | 3 |
| SPON1 | BICC1 | 0.71219 | 10 | 0 | 10 |
| SPON1 | SFRP2 | 0.711851 | 8 | 0 | 7 |
| SPON1 | PRPH2 | 0.706546 | 6 | 0 | 6 |
| SPON1 | OLFML1 | 0.704755 | 13 | 0 | 13 |
| SPON1 | VSTM4 | 0.704441 | 8 | 0 | 7 |
| SPON1 | PZP | 0.703711 | 4 | 0 | 4 |
| SPON1 | SHANK3 | 0.703541 | 3 | 0 | 3 |
| SPON1 | CYTL1 | 0.701097 | 5 | 0 | 4 |
| SPON1 | ADAMTS9-AS2 | 0.700665 | 3 | 0 | 3 |
| SPON1 | ST6GALNAC3 | 0.699808 | 6 | 0 | 5 |
| SPON1 | ACTC1 | 0.699571 | 6 | 0 | 5 |
| SPON1 | CCL11 | 0.696845 | 9 | 0 | 8 |
For details and further investigation, click here
