| Full name: tRNA methyltransferase 5 | Alias Symbol: TRM5 | ||
| Type: protein-coding gene | Cytoband: 14q23.1 | ||
| Entrez ID: 57570 | HGNC ID: HGNC:23141 | Ensembl Gene: ENSG00000126814 | OMIM ID: 611023 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of TRMT5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TRMT5 | 57570 | 221952_x_at | 0.0977 | 0.8055 | |
| GSE20347 | TRMT5 | 57570 | 221952_x_at | 0.3234 | 0.0581 | |
| GSE23400 | TRMT5 | 57570 | 221952_x_at | 0.5289 | 0.0000 | |
| GSE26886 | TRMT5 | 57570 | 221952_x_at | -0.2717 | 0.2045 | |
| GSE29001 | TRMT5 | 57570 | 221952_x_at | 0.4842 | 0.1092 | |
| GSE38129 | TRMT5 | 57570 | 221952_x_at | 0.2716 | 0.0306 | |
| GSE45670 | TRMT5 | 57570 | 221952_x_at | 0.0660 | 0.7489 | |
| GSE53622 | TRMT5 | 57570 | 115828 | 0.3889 | 0.0000 | |
| GSE53624 | TRMT5 | 57570 | 115828 | 0.3853 | 0.0000 | |
| GSE63941 | TRMT5 | 57570 | 221952_x_at | 1.2102 | 0.0055 | |
| GSE77861 | TRMT5 | 57570 | 221952_x_at | -0.2046 | 0.3868 | |
| GSE97050 | TRMT5 | 57570 | A_33_P3238976 | 0.0628 | 0.8171 | |
| SRP007169 | TRMT5 | 57570 | RNAseq | 0.9499 | 0.0133 | |
| SRP008496 | TRMT5 | 57570 | RNAseq | 0.9845 | 0.0002 | |
| SRP064894 | TRMT5 | 57570 | RNAseq | 0.3733 | 0.0008 | |
| SRP133303 | TRMT5 | 57570 | RNAseq | 0.3205 | 0.0480 | |
| SRP159526 | TRMT5 | 57570 | RNAseq | 0.1461 | 0.6193 | |
| SRP193095 | TRMT5 | 57570 | RNAseq | 0.2280 | 0.0412 | |
| SRP219564 | TRMT5 | 57570 | RNAseq | 0.4124 | 0.1955 | |
| TCGA | TRMT5 | 57570 | RNAseq | 0.0538 | 0.3256 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by TRMT5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TRMT5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TRMT5 | 57570 | 9 | 3 | 18 | |
| GSE20123 | TRMT5 | 57570 | 8 | 3 | 19 | |
| GSE43470 | TRMT5 | 57570 | 8 | 2 | 33 | |
| GSE46452 | TRMT5 | 57570 | 16 | 3 | 40 | |
| GSE47630 | TRMT5 | 57570 | 11 | 9 | 20 | |
| GSE54993 | TRMT5 | 57570 | 3 | 9 | 58 | |
| GSE54994 | TRMT5 | 57570 | 19 | 4 | 30 | |
| GSE60625 | TRMT5 | 57570 | 0 | 2 | 9 | |
| GSE74703 | TRMT5 | 57570 | 7 | 2 | 27 | |
| GSE74704 | TRMT5 | 57570 | 4 | 2 | 14 | |
| TCGA | TRMT5 | 57570 | 32 | 14 | 50 |
Total number of gains: 117; Total number of losses: 53; Total Number of normals: 318.
Somatic mutations of TRMT5:
Generating mutation plots.
Highly correlated genes for TRMT5:
Showing top 20/774 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TRMT5 | HMGN2 | 0.89519 | 13 | 0 | 12 |
| TRMT5 | TRIM47 | 0.771011 | 3 | 0 | 3 |
| TRMT5 | UNG | 0.767459 | 4 | 0 | 4 |
| TRMT5 | USP14 | 0.746035 | 3 | 0 | 3 |
| TRMT5 | HVCN1 | 0.724748 | 3 | 0 | 3 |
| TRMT5 | RCSD1 | 0.72196 | 3 | 0 | 3 |
| TRMT5 | POP5 | 0.712987 | 4 | 0 | 4 |
| TRMT5 | DCXR | 0.704557 | 3 | 0 | 3 |
| TRMT5 | PIP4K2A | 0.701115 | 3 | 0 | 3 |
| TRMT5 | MZT1 | 0.700886 | 3 | 0 | 3 |
| TRMT5 | FOXC1 | 0.700184 | 3 | 0 | 3 |
| TRMT5 | LILRB2 | 0.693809 | 3 | 0 | 3 |
| TRMT5 | EVL | 0.690938 | 4 | 0 | 3 |
| TRMT5 | TMED8 | 0.689224 | 4 | 0 | 3 |
| TRMT5 | BDH2 | 0.685476 | 3 | 0 | 3 |
| TRMT5 | MSH6 | 0.683201 | 8 | 0 | 8 |
| TRMT5 | CDCA4 | 0.682689 | 4 | 0 | 4 |
| TRMT5 | GALM | 0.681695 | 4 | 0 | 3 |
| TRMT5 | ATXN7L3B | 0.68114 | 3 | 0 | 3 |
| TRMT5 | SNRNP200 | 0.68103 | 3 | 0 | 3 |
For details and further investigation, click here
