| Full name: nuclear factor of activated T cells 2 | Alias Symbol: NF-ATP|NFATp|NFAT1 | ||
| Type: protein-coding gene | Cytoband: 20q13.2 | ||
| Entrez ID: 4773 | HGNC ID: HGNC:7776 | Ensembl Gene: ENSG00000101096 | OMIM ID: 600490 |
| Drug and gene relationship at DGIdb | |||
NFATC2 involved pathways:
Expression of NFATC2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NFATC2 | 4773 | 226991_at | -0.4581 | 0.5863 | |
| GSE26886 | NFATC2 | 4773 | 226991_at | -0.3442 | 0.1861 | |
| GSE45670 | NFATC2 | 4773 | 226991_at | -1.1023 | 0.0019 | |
| GSE53622 | NFATC2 | 4773 | 97845 | -0.6741 | 0.0000 | |
| GSE53624 | NFATC2 | 4773 | 97845 | -0.4835 | 0.0000 | |
| GSE63941 | NFATC2 | 4773 | 226991_at | 0.1315 | 0.8637 | |
| GSE77861 | NFATC2 | 4773 | 226991_at | 0.0730 | 0.7040 | |
| GSE97050 | NFATC2 | 4773 | A_23_P91278 | 0.4718 | 0.3176 | |
| SRP007169 | NFATC2 | 4773 | RNAseq | 1.0889 | 0.1596 | |
| SRP008496 | NFATC2 | 4773 | RNAseq | 1.3292 | 0.0221 | |
| SRP064894 | NFATC2 | 4773 | RNAseq | -0.3269 | 0.4946 | |
| SRP133303 | NFATC2 | 4773 | RNAseq | -1.1678 | 0.0010 | |
| SRP159526 | NFATC2 | 4773 | RNAseq | -1.2119 | 0.0665 | |
| SRP193095 | NFATC2 | 4773 | RNAseq | 0.1280 | 0.6687 | |
| SRP219564 | NFATC2 | 4773 | RNAseq | -0.4814 | 0.4141 | |
| TCGA | NFATC2 | 4773 | RNAseq | -1.0920 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 3.
Survival by NFATC2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NFATC2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NFATC2 | 4773 | 16 | 2 | 12 | |
| GSE20123 | NFATC2 | 4773 | 16 | 2 | 12 | |
| GSE43470 | NFATC2 | 4773 | 12 | 0 | 31 | |
| GSE46452 | NFATC2 | 4773 | 29 | 0 | 30 | |
| GSE47630 | NFATC2 | 4773 | 24 | 1 | 15 | |
| GSE54993 | NFATC2 | 4773 | 0 | 17 | 53 | |
| GSE54994 | NFATC2 | 4773 | 27 | 0 | 26 | |
| GSE60625 | NFATC2 | 4773 | 0 | 0 | 11 | |
| GSE74703 | NFATC2 | 4773 | 10 | 0 | 26 | |
| GSE74704 | NFATC2 | 4773 | 12 | 0 | 8 | |
| TCGA | NFATC2 | 4773 | 46 | 3 | 47 |
Total number of gains: 192; Total number of losses: 25; Total Number of normals: 271.
Somatic mutations of NFATC2:
Generating mutation plots.
Highly correlated genes for NFATC2:
Showing top 20/349 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NFATC2 | C11orf96 | 0.74977 | 3 | 0 | 3 |
| NFATC2 | GIMAP5 | 0.724033 | 3 | 0 | 3 |
| NFATC2 | ATF6 | 0.710027 | 3 | 0 | 3 |
| NFATC2 | APOL3 | 0.70967 | 3 | 0 | 3 |
| NFATC2 | FNIP2 | 0.703784 | 4 | 0 | 4 |
| NFATC2 | MYCT1 | 0.699873 | 4 | 0 | 3 |
| NFATC2 | PDK3 | 0.698599 | 3 | 0 | 3 |
| NFATC2 | NCKIPSD | 0.692583 | 3 | 0 | 3 |
| NFATC2 | TPP1 | 0.691882 | 3 | 0 | 3 |
| NFATC2 | PIP4K2A | 0.690863 | 4 | 0 | 3 |
| NFATC2 | LIMD2 | 0.685356 | 3 | 0 | 3 |
| NFATC2 | COL15A1 | 0.682063 | 4 | 0 | 4 |
| NFATC2 | SOBP | 0.678941 | 3 | 0 | 3 |
| NFATC2 | GNG2 | 0.677765 | 5 | 0 | 5 |
| NFATC2 | RASL12 | 0.675517 | 4 | 0 | 3 |
| NFATC2 | HNRNPH3 | 0.674805 | 3 | 0 | 3 |
| NFATC2 | GFPT2 | 0.673931 | 3 | 0 | 3 |
| NFATC2 | UHRF1BP1L | 0.67138 | 3 | 0 | 3 |
| NFATC2 | HABP4 | 0.671229 | 3 | 0 | 3 |
| NFATC2 | RNASE4 | 0.670907 | 3 | 0 | 3 |
For details and further investigation, click here
