| Full name: cAMP-dependent protein kinase inhibitor alpha | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 8q21.13 | ||
| Entrez ID: 5569 | HGNC ID: HGNC:9017 | Ensembl Gene: ENSG00000171033 | OMIM ID: 606059 |
| Drug and gene relationship at DGIdb | |||
PKIA involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05034 | Alcoholism |
Expression of PKIA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PKIA | 5569 | 204612_at | -0.3470 | 0.3685 | |
| GSE20347 | PKIA | 5569 | 204612_at | -0.7655 | 0.0308 | |
| GSE23400 | PKIA | 5569 | 204612_at | -0.1869 | 0.0020 | |
| GSE26886 | PKIA | 5569 | 204612_at | -2.2945 | 0.0001 | |
| GSE29001 | PKIA | 5569 | 204612_at | -1.1607 | 0.0019 | |
| GSE38129 | PKIA | 5569 | 204612_at | -0.5716 | 0.0273 | |
| GSE45670 | PKIA | 5569 | 204612_at | -0.2970 | 0.4515 | |
| GSE53622 | PKIA | 5569 | 45062 | -1.1723 | 0.0000 | |
| GSE53624 | PKIA | 5569 | 45062 | -1.3727 | 0.0000 | |
| GSE63941 | PKIA | 5569 | 204612_at | -2.5669 | 0.0716 | |
| GSE77861 | PKIA | 5569 | 204612_at | -0.7381 | 0.0046 | |
| GSE97050 | PKIA | 5569 | A_23_P31765 | -0.2733 | 0.3051 | |
| SRP007169 | PKIA | 5569 | RNAseq | -0.3388 | 0.6973 | |
| SRP064894 | PKIA | 5569 | RNAseq | -0.1764 | 0.4873 | |
| SRP133303 | PKIA | 5569 | RNAseq | -0.7809 | 0.0154 | |
| SRP159526 | PKIA | 5569 | RNAseq | -0.5855 | 0.2815 | |
| SRP193095 | PKIA | 5569 | RNAseq | -1.3804 | 0.0000 | |
| SRP219564 | PKIA | 5569 | RNAseq | -0.9809 | 0.1153 | |
| TCGA | PKIA | 5569 | RNAseq | -0.1400 | 0.5533 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by PKIA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PKIA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PKIA | 5569 | 16 | 1 | 13 | |
| GSE20123 | PKIA | 5569 | 18 | 1 | 11 | |
| GSE43470 | PKIA | 5569 | 18 | 1 | 24 | |
| GSE46452 | PKIA | 5569 | 21 | 0 | 38 | |
| GSE47630 | PKIA | 5569 | 23 | 0 | 17 | |
| GSE54993 | PKIA | 5569 | 0 | 19 | 51 | |
| GSE54994 | PKIA | 5569 | 30 | 0 | 23 | |
| GSE60625 | PKIA | 5569 | 0 | 4 | 7 | |
| GSE74703 | PKIA | 5569 | 15 | 1 | 20 | |
| GSE74704 | PKIA | 5569 | 12 | 0 | 8 | |
| TCGA | PKIA | 5569 | 51 | 3 | 42 |
Total number of gains: 204; Total number of losses: 30; Total Number of normals: 254.
Somatic mutations of PKIA:
Generating mutation plots.
Highly correlated genes for PKIA:
Showing top 20/906 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PKIA | ZFY | 0.821641 | 3 | 0 | 3 |
| PKIA | GPRASP2 | 0.755497 | 3 | 0 | 3 |
| PKIA | NR2F1 | 0.729454 | 3 | 0 | 3 |
| PKIA | KBTBD3 | 0.729117 | 3 | 0 | 3 |
| PKIA | KCTD21 | 0.719817 | 3 | 0 | 3 |
| PKIA | MAMDC4 | 0.700855 | 3 | 0 | 3 |
| PKIA | RPS4Y1 | 0.69184 | 3 | 0 | 3 |
| PKIA | HDHD2 | 0.689121 | 5 | 0 | 4 |
| PKIA | CGNL1 | 0.686934 | 7 | 0 | 6 |
| PKIA | TMEM38A | 0.685681 | 4 | 0 | 3 |
| PKIA | SPAG1 | 0.684351 | 3 | 0 | 3 |
| PKIA | UFM1 | 0.681439 | 3 | 0 | 3 |
| PKIA | TRA2A | 0.680521 | 3 | 0 | 3 |
| PKIA | LPCAT4 | 0.677747 | 3 | 0 | 3 |
| PKIA | CCL28 | 0.677239 | 3 | 0 | 3 |
| PKIA | PRKAR2A | 0.677198 | 4 | 0 | 3 |
| PKIA | LRRK2 | 0.676331 | 7 | 0 | 7 |
| PKIA | ARG2 | 0.676041 | 3 | 0 | 3 |
| PKIA | FBXO28 | 0.67604 | 3 | 0 | 3 |
| PKIA | TAB3 | 0.672404 | 5 | 0 | 4 |
For details and further investigation, click here
