| Full name: placenta associated 8 | Alias Symbol: onzin|C15 | ||
| Type: protein-coding gene | Cytoband: 4q21.22 | ||
| Entrez ID: 51316 | HGNC ID: HGNC:19254 | Ensembl Gene: ENSG00000145287 | OMIM ID: 607515 |
| Drug and gene relationship at DGIdb | |||
Expression of PLAC8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLAC8 | 51316 | 219014_at | -1.3488 | 0.4384 | |
| GSE20347 | PLAC8 | 51316 | 219014_at | -3.1123 | 0.0001 | |
| GSE23400 | PLAC8 | 51316 | 219014_at | -2.1651 | 0.0000 | |
| GSE26886 | PLAC8 | 51316 | 219014_at | -4.2003 | 0.0000 | |
| GSE29001 | PLAC8 | 51316 | 219014_at | -2.2371 | 0.0001 | |
| GSE38129 | PLAC8 | 51316 | 219014_at | -2.4223 | 0.0001 | |
| GSE45670 | PLAC8 | 51316 | 219014_at | -0.5464 | 0.5949 | |
| GSE53622 | PLAC8 | 51316 | 97715 | -2.0775 | 0.0000 | |
| GSE53624 | PLAC8 | 51316 | 97715 | -2.7335 | 0.0000 | |
| GSE63941 | PLAC8 | 51316 | 219014_at | 3.6873 | 0.0448 | |
| GSE77861 | PLAC8 | 51316 | 219014_at | -3.4621 | 0.0110 | |
| GSE97050 | PLAC8 | 51316 | A_24_P183128 | -0.3695 | 0.8107 | |
| SRP007169 | PLAC8 | 51316 | RNAseq | -2.3958 | 0.0003 | |
| SRP008496 | PLAC8 | 51316 | RNAseq | -1.9707 | 0.0138 | |
| SRP064894 | PLAC8 | 51316 | RNAseq | -1.1471 | 0.0444 | |
| SRP133303 | PLAC8 | 51316 | RNAseq | -1.1576 | 0.0163 | |
| SRP159526 | PLAC8 | 51316 | RNAseq | -3.6600 | 0.0000 | |
| SRP193095 | PLAC8 | 51316 | RNAseq | -2.4747 | 0.0000 | |
| SRP219564 | PLAC8 | 51316 | RNAseq | -2.3634 | 0.0108 | |
| TCGA | PLAC8 | 51316 | RNAseq | -0.8952 | 0.0091 |
Upregulated datasets: 1; Downregulated datasets: 15.
Survival by PLAC8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PLAC8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLAC8 | 51316 | 2 | 11 | 17 | |
| GSE20123 | PLAC8 | 51316 | 2 | 11 | 17 | |
| GSE43470 | PLAC8 | 51316 | 0 | 13 | 30 | |
| GSE46452 | PLAC8 | 51316 | 1 | 36 | 22 | |
| GSE47630 | PLAC8 | 51316 | 0 | 20 | 20 | |
| GSE54993 | PLAC8 | 51316 | 8 | 0 | 62 | |
| GSE54994 | PLAC8 | 51316 | 1 | 9 | 43 | |
| GSE60625 | PLAC8 | 51316 | 0 | 0 | 11 | |
| GSE74703 | PLAC8 | 51316 | 0 | 11 | 25 | |
| GSE74704 | PLAC8 | 51316 | 1 | 6 | 13 | |
| TCGA | PLAC8 | 51316 | 12 | 34 | 50 |
Total number of gains: 27; Total number of losses: 151; Total Number of normals: 310.
Somatic mutations of PLAC8:
Generating mutation plots.
Highly correlated genes for PLAC8:
Showing top 20/1093 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLAC8 | TMPRSS11E | 0.765426 | 11 | 0 | 11 |
| PLAC8 | ARHGAP27 | 0.76255 | 8 | 0 | 8 |
| PLAC8 | ZDHHC13 | 0.759309 | 11 | 0 | 11 |
| PLAC8 | PRSS3 | 0.752143 | 11 | 0 | 11 |
| PLAC8 | FAM214A | 0.749099 | 6 | 0 | 6 |
| PLAC8 | CLIC3 | 0.741753 | 9 | 0 | 9 |
| PLAC8 | PCBP1-AS1 | 0.738364 | 3 | 0 | 3 |
| PLAC8 | FAM3B | 0.738118 | 7 | 0 | 6 |
| PLAC8 | ATP13A4 | 0.736798 | 8 | 0 | 7 |
| PLAC8 | MUC15 | 0.732906 | 6 | 0 | 6 |
| PLAC8 | CYP2C18 | 0.732657 | 11 | 0 | 10 |
| PLAC8 | ST6GALNAC1 | 0.728343 | 7 | 0 | 6 |
| PLAC8 | TP53I3 | 0.726628 | 11 | 0 | 11 |
| PLAC8 | CEACAM7 | 0.726624 | 12 | 0 | 11 |
| PLAC8 | ANXA9 | 0.726381 | 12 | 0 | 12 |
| PLAC8 | RBM47 | 0.726337 | 12 | 0 | 12 |
| PLAC8 | CXCR2 | 0.725568 | 10 | 0 | 9 |
| PLAC8 | GALNT12 | 0.72547 | 10 | 0 | 10 |
| PLAC8 | LIPH | 0.724346 | 7 | 0 | 7 |
| PLAC8 | TPRG1 | 0.723675 | 7 | 0 | 7 |
For details and further investigation, click here
