| Full name: matrix metallopeptidase 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 11q22.2 | ||
| Entrez ID: 4314 | HGNC ID: HGNC:7173 | Ensembl Gene: ENSG00000149968 | OMIM ID: 185250 |
| Drug and gene relationship at DGIdb | |||
Expression of MMP3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MMP3 | 4314 | 205828_at | 4.2637 | 0.0978 | |
| GSE20347 | MMP3 | 4314 | 205828_at | 1.9110 | 0.0004 | |
| GSE23400 | MMP3 | 4314 | 205828_at | 1.3288 | 0.0000 | |
| GSE26886 | MMP3 | 4314 | 205828_at | 3.0095 | 0.0003 | |
| GSE29001 | MMP3 | 4314 | 205828_at | 1.2678 | 0.0238 | |
| GSE38129 | MMP3 | 4314 | 205828_at | 2.6466 | 0.0000 | |
| GSE45670 | MMP3 | 4314 | 205828_at | 4.9800 | 0.0000 | |
| GSE53622 | MMP3 | 4314 | 38617 | 5.9381 | 0.0000 | |
| GSE53624 | MMP3 | 4314 | 38617 | 5.4964 | 0.0000 | |
| GSE63941 | MMP3 | 4314 | 205828_at | -7.4975 | 0.0000 | |
| GSE77861 | MMP3 | 4314 | 205828_at | 2.5256 | 0.0078 | |
| GSE97050 | MMP3 | 4314 | A_23_P161698 | 1.0575 | 0.0555 | |
| SRP007169 | MMP3 | 4314 | RNAseq | 5.9730 | 0.0000 | |
| SRP008496 | MMP3 | 4314 | RNAseq | 7.1624 | 0.0000 | |
| SRP133303 | MMP3 | 4314 | RNAseq | 7.1697 | 0.0000 | |
| SRP159526 | MMP3 | 4314 | RNAseq | 7.8572 | 0.0000 | |
| SRP219564 | MMP3 | 4314 | RNAseq | 7.1789 | 0.0000 | |
| TCGA | MMP3 | 4314 | RNAseq | 2.1690 | 0.0000 |
Upregulated datasets: 15; Downregulated datasets: 1.
Survival by MMP3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MMP3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MMP3 | 4314 | 4 | 8 | 18 | |
| GSE20123 | MMP3 | 4314 | 5 | 8 | 17 | |
| GSE43470 | MMP3 | 4314 | 5 | 5 | 33 | |
| GSE46452 | MMP3 | 4314 | 5 | 24 | 30 | |
| GSE47630 | MMP3 | 4314 | 2 | 19 | 19 | |
| GSE54993 | MMP3 | 4314 | 9 | 2 | 59 | |
| GSE54994 | MMP3 | 4314 | 6 | 18 | 29 | |
| GSE60625 | MMP3 | 4314 | 0 | 3 | 8 | |
| GSE74703 | MMP3 | 4314 | 3 | 4 | 29 | |
| GSE74704 | MMP3 | 4314 | 5 | 4 | 11 | |
| TCGA | MMP3 | 4314 | 10 | 44 | 42 |
Total number of gains: 54; Total number of losses: 139; Total Number of normals: 295.
Somatic mutations of MMP3:
Generating mutation plots.
Highly correlated genes for MMP3:
Showing top 20/1470 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MMP3 | MICAL1 | 0.843234 | 3 | 0 | 3 |
| MMP3 | MMP1 | 0.827677 | 13 | 0 | 13 |
| MMP3 | ALPK2 | 0.807485 | 3 | 0 | 3 |
| MMP3 | FAM89A | 0.796531 | 3 | 0 | 3 |
| MMP3 | PYCR2 | 0.782257 | 3 | 0 | 3 |
| MMP3 | CD200 | 0.77676 | 3 | 0 | 3 |
| MMP3 | WDR54 | 0.774084 | 7 | 0 | 6 |
| MMP3 | SLC39A3 | 0.765145 | 3 | 0 | 3 |
| MMP3 | FADS1 | 0.755207 | 3 | 0 | 3 |
| MMP3 | EBNA1BP2 | 0.750313 | 3 | 0 | 3 |
| MMP3 | PLEKHA4 | 0.745506 | 3 | 0 | 3 |
| MMP3 | CTHRC1 | 0.742836 | 8 | 0 | 8 |
| MMP3 | CXCL8 | 0.742151 | 10 | 0 | 10 |
| MMP3 | ZNF707 | 0.738499 | 3 | 0 | 3 |
| MMP3 | LOXL2 | 0.73607 | 11 | 0 | 11 |
| MMP3 | CCM2 | 0.732336 | 6 | 0 | 6 |
| MMP3 | BOLA3 | 0.72848 | 6 | 0 | 6 |
| MMP3 | CCL11 | 0.728129 | 3 | 0 | 3 |
| MMP3 | TMEM138 | 0.727577 | 6 | 0 | 6 |
| MMP3 | LRRC8C | 0.726681 | 3 | 0 | 3 |
For details and further investigation, click here
