| Full name: pleiotropic regulator 1 | Alias Symbol: PRL1|Prp46|PRPF46|Cwc1|TANGO4 | ||
| Type: protein-coding gene | Cytoband: 4q31.3 | ||
| Entrez ID: 5356 | HGNC ID: HGNC:9089 | Ensembl Gene: ENSG00000171566 | OMIM ID: 605961 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PLRG1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLRG1 | 5356 | 225194_at | -0.1518 | 0.7288 | |
| GSE26886 | PLRG1 | 5356 | 225194_at | -1.2370 | 0.0000 | |
| GSE45670 | PLRG1 | 5356 | 225194_at | 0.1506 | 0.2576 | |
| GSE53622 | PLRG1 | 5356 | 123217 | -0.0383 | 0.5343 | |
| GSE53624 | PLRG1 | 5356 | 123217 | 0.0286 | 0.6134 | |
| GSE63941 | PLRG1 | 5356 | 225194_at | -0.1360 | 0.8043 | |
| GSE77861 | PLRG1 | 5356 | 225194_at | 0.0568 | 0.7868 | |
| GSE97050 | PLRG1 | 5356 | A_23_P84775 | 0.2801 | 0.3200 | |
| SRP007169 | PLRG1 | 5356 | RNAseq | -0.0512 | 0.8964 | |
| SRP008496 | PLRG1 | 5356 | RNAseq | -0.2375 | 0.2393 | |
| SRP064894 | PLRG1 | 5356 | RNAseq | -0.0842 | 0.4600 | |
| SRP133303 | PLRG1 | 5356 | RNAseq | 0.2331 | 0.0700 | |
| SRP159526 | PLRG1 | 5356 | RNAseq | -0.2290 | 0.2192 | |
| SRP193095 | PLRG1 | 5356 | RNAseq | -0.2560 | 0.0245 | |
| SRP219564 | PLRG1 | 5356 | RNAseq | -0.6268 | 0.0696 | |
| TCGA | PLRG1 | 5356 | RNAseq | 0.0828 | 0.1035 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by PLRG1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PLRG1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLRG1 | 5356 | 0 | 14 | 16 | |
| GSE20123 | PLRG1 | 5356 | 0 | 14 | 16 | |
| GSE43470 | PLRG1 | 5356 | 0 | 13 | 30 | |
| GSE46452 | PLRG1 | 5356 | 1 | 36 | 22 | |
| GSE47630 | PLRG1 | 5356 | 0 | 23 | 17 | |
| GSE54993 | PLRG1 | 5356 | 10 | 0 | 60 | |
| GSE54994 | PLRG1 | 5356 | 1 | 13 | 39 | |
| GSE60625 | PLRG1 | 5356 | 0 | 1 | 10 | |
| GSE74703 | PLRG1 | 5356 | 0 | 11 | 25 | |
| GSE74704 | PLRG1 | 5356 | 0 | 7 | 13 | |
| TCGA | PLRG1 | 5356 | 10 | 34 | 52 |
Total number of gains: 22; Total number of losses: 166; Total Number of normals: 300.
Somatic mutations of PLRG1:
Generating mutation plots.
Highly correlated genes for PLRG1:
Showing top 20/71 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLRG1 | ACAD8 | 0.691594 | 3 | 0 | 3 |
| PLRG1 | WDR31 | 0.681991 | 3 | 0 | 3 |
| PLRG1 | PNP | 0.672886 | 3 | 0 | 3 |
| PLRG1 | NAA25 | 0.666144 | 3 | 0 | 3 |
| PLRG1 | DOCK10 | 0.660053 | 3 | 0 | 3 |
| PLRG1 | ARHGAP26 | 0.653461 | 4 | 0 | 3 |
| PLRG1 | VPS29 | 0.642542 | 3 | 0 | 3 |
| PLRG1 | RAB2A | 0.627975 | 3 | 0 | 3 |
| PLRG1 | MANF | 0.618526 | 3 | 0 | 3 |
| PLRG1 | AK2 | 0.615112 | 4 | 0 | 3 |
| PLRG1 | AASDH | 0.614745 | 4 | 0 | 3 |
| PLRG1 | ATP6V1B2 | 0.614345 | 4 | 0 | 3 |
| PLRG1 | TMED2 | 0.611664 | 4 | 0 | 3 |
| PLRG1 | SFT2D1 | 0.610858 | 4 | 0 | 3 |
| PLRG1 | MAP2K1 | 0.610559 | 3 | 0 | 3 |
| PLRG1 | DCTD | 0.607034 | 5 | 0 | 4 |
| PLRG1 | PHB | 0.604708 | 3 | 0 | 3 |
| PLRG1 | KLRB1 | 0.59863 | 3 | 0 | 3 |
| PLRG1 | ABCE1 | 0.59698 | 6 | 0 | 4 |
| PLRG1 | THG1L | 0.58998 | 5 | 0 | 4 |
For details and further investigation, click here
