| Full name: mesencephalic astrocyte derived neurotrophic factor | Alias Symbol: ARP | ||
| Type: protein-coding gene | Cytoband: 3p21.2 | ||
| Entrez ID: 7873 | HGNC ID: HGNC:15461 | Ensembl Gene: ENSG00000145050 | OMIM ID: 601916 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MANF:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MANF | 7873 | 202655_at | 0.2225 | 0.6552 | |
| GSE20347 | MANF | 7873 | 202655_at | -0.4092 | 0.0075 | |
| GSE23400 | MANF | 7873 | 202655_at | 0.0089 | 0.8940 | |
| GSE26886 | MANF | 7873 | 202655_at | -0.6704 | 0.0009 | |
| GSE29001 | MANF | 7873 | 202655_at | -0.5861 | 0.0523 | |
| GSE38129 | MANF | 7873 | 202655_at | -0.0913 | 0.5446 | |
| GSE45670 | MANF | 7873 | 202655_at | 0.4885 | 0.0005 | |
| GSE53622 | MANF | 7873 | 24474 | 0.0543 | 0.5247 | |
| GSE53624 | MANF | 7873 | 24474 | 0.1054 | 0.0515 | |
| GSE63941 | MANF | 7873 | 202655_at | -0.9998 | 0.4414 | |
| GSE77861 | MANF | 7873 | 202655_at | -0.3627 | 0.0658 | |
| GSE97050 | MANF | 7873 | A_23_P132793 | 0.4951 | 0.2712 | |
| SRP007169 | MANF | 7873 | RNAseq | -1.0018 | 0.0055 | |
| SRP008496 | MANF | 7873 | RNAseq | -0.7877 | 0.0002 | |
| SRP064894 | MANF | 7873 | RNAseq | 0.1689 | 0.4991 | |
| SRP133303 | MANF | 7873 | RNAseq | 0.3699 | 0.0123 | |
| SRP159526 | MANF | 7873 | RNAseq | 0.0964 | 0.7966 | |
| SRP193095 | MANF | 7873 | RNAseq | -0.5407 | 0.0001 | |
| SRP219564 | MANF | 7873 | RNAseq | 0.0518 | 0.8590 | |
| TCGA | MANF | 7873 | RNAseq | -0.0332 | 0.5755 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by MANF expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MANF:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MANF | 7873 | 0 | 18 | 12 | |
| GSE20123 | MANF | 7873 | 0 | 19 | 11 | |
| GSE43470 | MANF | 7873 | 0 | 18 | 25 | |
| GSE46452 | MANF | 7873 | 2 | 16 | 41 | |
| GSE47630 | MANF | 7873 | 1 | 24 | 15 | |
| GSE54993 | MANF | 7873 | 6 | 2 | 62 | |
| GSE54994 | MANF | 7873 | 0 | 34 | 19 | |
| GSE60625 | MANF | 7873 | 5 | 0 | 6 | |
| GSE74703 | MANF | 7873 | 0 | 14 | 22 | |
| GSE74704 | MANF | 7873 | 0 | 12 | 8 | |
| TCGA | MANF | 7873 | 0 | 78 | 18 |
Total number of gains: 14; Total number of losses: 235; Total Number of normals: 239.
Somatic mutations of MANF:
Generating mutation plots.
Highly correlated genes for MANF:
Showing top 20/224 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MANF | IL12RB1 | 0.712635 | 3 | 0 | 3 |
| MANF | UBE2E1 | 0.680015 | 5 | 0 | 4 |
| MANF | KLRD1 | 0.677763 | 3 | 0 | 3 |
| MANF | S100A16 | 0.65054 | 3 | 0 | 3 |
| MANF | FAM83C | 0.649281 | 4 | 0 | 4 |
| MANF | CXCR6 | 0.648177 | 3 | 0 | 3 |
| MANF | PARP15 | 0.647131 | 3 | 0 | 3 |
| MANF | HS3ST3B1 | 0.644673 | 4 | 0 | 3 |
| MANF | SLC27A4 | 0.64457 | 4 | 0 | 3 |
| MANF | SPRR1B | 0.638776 | 3 | 0 | 3 |
| MANF | SPCS1 | 0.637523 | 5 | 0 | 4 |
| MANF | GPT2 | 0.631285 | 3 | 0 | 3 |
| MANF | TINCR | 0.630832 | 3 | 0 | 3 |
| MANF | ITGB7 | 0.626315 | 4 | 0 | 3 |
| MANF | PSMD6 | 0.622244 | 5 | 0 | 5 |
| MANF | RHOA | 0.620613 | 6 | 0 | 5 |
| MANF | UBE2V2 | 0.618968 | 3 | 0 | 3 |
| MANF | PLRG1 | 0.618526 | 3 | 0 | 3 |
| MANF | PNP | 0.617644 | 5 | 0 | 4 |
| MANF | RNF212 | 0.615688 | 3 | 0 | 3 |
For details and further investigation, click here
