| Full name: tRNA-histidine guanylyltransferase 1 like | Alias Symbol: ICF45|FLJ11601|FLJ20546|IHG-1|hTHG1 | ||
| Type: protein-coding gene | Cytoband: 5q33.3 | ||
| Entrez ID: 54974 | HGNC ID: HGNC:26053 | Ensembl Gene: ENSG00000113272 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of THG1L:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | THG1L | 54974 | 219122_s_at | -0.0794 | 0.8752 | |
| GSE20347 | THG1L | 54974 | 219122_s_at | -0.1342 | 0.2756 | |
| GSE23400 | THG1L | 54974 | 219122_s_at | -0.0513 | 0.3241 | |
| GSE26886 | THG1L | 54974 | 219122_s_at | -0.6423 | 0.0006 | |
| GSE29001 | THG1L | 54974 | 219122_s_at | -0.0965 | 0.7702 | |
| GSE38129 | THG1L | 54974 | 219122_s_at | -0.0132 | 0.9279 | |
| GSE45670 | THG1L | 54974 | 219122_s_at | 0.1922 | 0.1499 | |
| GSE53622 | THG1L | 54974 | 6165 | -0.3622 | 0.0006 | |
| GSE53624 | THG1L | 54974 | 6165 | -0.0563 | 0.6048 | |
| GSE63941 | THG1L | 54974 | 219122_s_at | 0.8922 | 0.0903 | |
| GSE77861 | THG1L | 54974 | 219122_s_at | -0.0663 | 0.7189 | |
| GSE97050 | THG1L | 54974 | A_23_P121956 | 0.1071 | 0.6701 | |
| SRP007169 | THG1L | 54974 | RNAseq | -0.0014 | 0.9976 | |
| SRP008496 | THG1L | 54974 | RNAseq | 0.0077 | 0.9818 | |
| SRP064894 | THG1L | 54974 | RNAseq | -0.0578 | 0.6930 | |
| SRP133303 | THG1L | 54974 | RNAseq | -0.1718 | 0.0984 | |
| SRP159526 | THG1L | 54974 | RNAseq | -0.6880 | 0.0412 | |
| SRP193095 | THG1L | 54974 | RNAseq | -0.5668 | 0.0000 | |
| SRP219564 | THG1L | 54974 | RNAseq | -0.0817 | 0.6871 | |
| TCGA | THG1L | 54974 | RNAseq | -0.0339 | 0.6367 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by THG1L expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of THG1L:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | THG1L | 54974 | 0 | 11 | 19 | |
| GSE20123 | THG1L | 54974 | 0 | 11 | 19 | |
| GSE43470 | THG1L | 54974 | 2 | 11 | 30 | |
| GSE46452 | THG1L | 54974 | 0 | 27 | 32 | |
| GSE47630 | THG1L | 54974 | 0 | 20 | 20 | |
| GSE54993 | THG1L | 54974 | 9 | 1 | 60 | |
| GSE54994 | THG1L | 54974 | 1 | 16 | 36 | |
| GSE60625 | THG1L | 54974 | 0 | 0 | 11 | |
| GSE74703 | THG1L | 54974 | 2 | 8 | 26 | |
| GSE74704 | THG1L | 54974 | 0 | 6 | 14 | |
| TCGA | THG1L | 54974 | 5 | 36 | 55 |
Total number of gains: 19; Total number of losses: 147; Total Number of normals: 322.
Somatic mutations of THG1L:
Generating mutation plots.
Highly correlated genes for THG1L:
Showing top 20/191 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| THG1L | TBC1D4 | 0.757491 | 3 | 0 | 3 |
| THG1L | SLC10A7 | 0.755985 | 3 | 0 | 3 |
| THG1L | GFM2 | 0.743706 | 3 | 0 | 3 |
| THG1L | C1GALT1C1 | 0.715811 | 3 | 0 | 3 |
| THG1L | ATRIP | 0.705642 | 3 | 0 | 3 |
| THG1L | GGA3 | 0.705145 | 3 | 0 | 3 |
| THG1L | MTRF1L | 0.698953 | 3 | 0 | 3 |
| THG1L | TBCC | 0.698841 | 3 | 0 | 3 |
| THG1L | KDM3B | 0.695733 | 3 | 0 | 3 |
| THG1L | MTSS1 | 0.695197 | 3 | 0 | 3 |
| THG1L | ARRDC3 | 0.692512 | 3 | 0 | 3 |
| THG1L | ATP6V1E1 | 0.691525 | 3 | 0 | 3 |
| THG1L | GMPPB | 0.690506 | 3 | 0 | 3 |
| THG1L | C3orf38 | 0.67221 | 3 | 0 | 3 |
| THG1L | TYW3 | 0.668943 | 4 | 0 | 3 |
| THG1L | RNF185 | 0.668874 | 3 | 0 | 3 |
| THG1L | CRADD | 0.668204 | 4 | 0 | 3 |
| THG1L | ALG14 | 0.665817 | 4 | 0 | 4 |
| THG1L | SEC63 | 0.663567 | 3 | 0 | 3 |
| THG1L | GPR108 | 0.663253 | 3 | 0 | 3 |
For details and further investigation, click here
