| Full name: purine nucleoside phosphorylase | Alias Symbol: PUNP | ||
| Type: protein-coding gene | Cytoband: 14q11.2 | ||
| Entrez ID: 4860 | HGNC ID: HGNC:7892 | Ensembl Gene: ENSG00000198805 | OMIM ID: 164050 |
| Drug and gene relationship at DGIdb | |||
Expression of PNP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PNP | 4860 | 201695_s_at | -0.1716 | 0.8709 | |
| GSE20347 | PNP | 4860 | 201695_s_at | -0.5062 | 0.0391 | |
| GSE23400 | PNP | 4860 | 201695_s_at | -0.1985 | 0.0682 | |
| GSE26886 | PNP | 4860 | 201695_s_at | -1.4286 | 0.0000 | |
| GSE29001 | PNP | 4860 | 201695_s_at | -0.4237 | 0.2038 | |
| GSE38129 | PNP | 4860 | 201695_s_at | -0.1148 | 0.7377 | |
| GSE45670 | PNP | 4860 | 201695_s_at | 0.4200 | 0.0517 | |
| GSE63941 | PNP | 4860 | 201695_s_at | 2.7036 | 0.0000 | |
| GSE77861 | PNP | 4860 | 201695_s_at | 0.1715 | 0.6642 | |
| GSE97050 | PNP | 4860 | A_23_P140256 | 0.7998 | 0.1095 | |
| SRP007169 | PNP | 4860 | RNAseq | -1.7073 | 0.0000 | |
| SRP008496 | PNP | 4860 | RNAseq | -1.6814 | 0.0000 | |
| SRP064894 | PNP | 4860 | RNAseq | 0.0397 | 0.8590 | |
| SRP133303 | PNP | 4860 | RNAseq | -0.1515 | 0.5251 | |
| SRP159526 | PNP | 4860 | RNAseq | -0.9224 | 0.0009 | |
| SRP193095 | PNP | 4860 | RNAseq | -0.5441 | 0.0066 | |
| SRP219564 | PNP | 4860 | RNAseq | -0.7892 | 0.0632 | |
| TCGA | PNP | 4860 | RNAseq | -0.0156 | 0.8372 |
Upregulated datasets: 1; Downregulated datasets: 3.
Survival by PNP expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of PNP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PNP | 4860 | 10 | 3 | 17 | |
| GSE20123 | PNP | 4860 | 8 | 3 | 19 | |
| GSE43470 | PNP | 4860 | 7 | 1 | 35 | |
| GSE46452 | PNP | 4860 | 19 | 2 | 38 | |
| GSE47630 | PNP | 4860 | 10 | 10 | 20 | |
| GSE54993 | PNP | 4860 | 3 | 11 | 56 | |
| GSE54994 | PNP | 4860 | 18 | 5 | 30 | |
| GSE60625 | PNP | 4860 | 0 | 2 | 9 | |
| GSE74703 | PNP | 4860 | 6 | 1 | 29 | |
| GSE74704 | PNP | 4860 | 4 | 2 | 14 | |
| TCGA | PNP | 4860 | 28 | 16 | 52 |
Total number of gains: 113; Total number of losses: 56; Total Number of normals: 319.
Somatic mutations of PNP:
Generating mutation plots.
Highly correlated genes for PNP:
Showing top 20/521 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PNP | SLAMF7 | 0.735128 | 3 | 0 | 3 |
| PNP | PRELID1 | 0.734739 | 3 | 0 | 3 |
| PNP | OCIAD1 | 0.730979 | 3 | 0 | 3 |
| PNP | NIPAL4 | 0.727386 | 5 | 0 | 5 |
| PNP | NUP35 | 0.723298 | 3 | 0 | 3 |
| PNP | GFM2 | 0.722365 | 3 | 0 | 3 |
| PNP | FAM83D | 0.717154 | 3 | 0 | 3 |
| PNP | PANK3 | 0.715575 | 3 | 0 | 3 |
| PNP | GINS3 | 0.71113 | 4 | 0 | 3 |
| PNP | MATR3 | 0.710251 | 3 | 0 | 3 |
| PNP | ARL6IP6 | 0.707446 | 3 | 0 | 3 |
| PNP | FYTTD1 | 0.707347 | 3 | 0 | 3 |
| PNP | RIPK3 | 0.706689 | 3 | 0 | 3 |
| PNP | GTF2B | 0.701033 | 3 | 0 | 3 |
| PNP | DHX35 | 0.699528 | 3 | 0 | 3 |
| PNP | UTP15 | 0.694181 | 3 | 0 | 3 |
| PNP | CMIP | 0.693919 | 3 | 0 | 3 |
| PNP | SCFD1 | 0.693528 | 6 | 0 | 6 |
| PNP | MMADHC | 0.692945 | 4 | 0 | 4 |
| PNP | USP45 | 0.691917 | 3 | 0 | 3 |
For details and further investigation, click here
