PHB

 

Full name: prohibitin Alias Symbol: PHB1
Type: protein-coding gene Cytoband: 17q21.33
Entrez ID: 5245 HGNC ID: HGNC:8912 Ensembl Gene: ENSG00000167085 OMIM ID: 176705
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of PHB:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PHB 5245 200658_s_at 0.6469 0.0719
GSE20347 PHB 5245 200658_s_at 0.5634 0.0018
GSE23400 PHB 5245 200659_s_at 0.1386 0.0091
GSE26886 PHB 5245 200659_s_at -0.2766 0.0859
GSE29001 PHB 5245 200659_s_at 0.0382 0.8803
GSE38129 PHB 5245 200658_s_at 0.8001 0.0000
GSE45670 PHB 5245 200658_s_at 0.4646 0.0315
GSE53622 PHB 5245 88017 0.2506 0.0000
GSE53624 PHB 5245 88017 0.4908 0.0000
GSE63941 PHB 5245 200658_s_at 1.1839 0.0013
GSE77861 PHB 5245 200658_s_at 0.6738 0.0223
GSE97050 PHB 5245 A_24_P262355 -0.0349 0.9114
SRP007169 PHB 5245 RNAseq 0.3438 0.2233
SRP008496 PHB 5245 RNAseq 0.1144 0.4887
SRP064894 PHB 5245 RNAseq 0.6401 0.0231
SRP133303 PHB 5245 RNAseq 0.3847 0.0082
SRP159526 PHB 5245 RNAseq 0.5767 0.0192
SRP193095 PHB 5245 RNAseq 0.0162 0.8888
SRP219564 PHB 5245 RNAseq 0.2784 0.4855
TCGA PHB 5245 RNAseq 0.0799 0.0939

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by PHB expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PHB:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PHB 5245 6 2 22
GSE20123 PHB 5245 6 2 22
GSE43470 PHB 5245 3 2 38
GSE46452 PHB 5245 32 0 27
GSE47630 PHB 5245 9 0 31
GSE54993 PHB 5245 2 4 64
GSE54994 PHB 5245 10 5 38
GSE60625 PHB 5245 4 0 7
GSE74703 PHB 5245 3 2 31
GSE74704 PHB 5245 4 1 15
TCGA PHB 5245 27 7 62

Total number of gains: 106; Total number of losses: 25; Total Number of normals: 357.  

 

Somatic mutations of PHB:

 

Generating mutation plots.

 

Highly correlated genes for PHB:

 

Showing top 20/1267 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PHBCDC42EP30.765534303
PHBNIPA10.760836404
PHBPTGES30.734311706
PHBSETX0.730228303
PHBATG4C0.729979303
PHBCNBP0.719292606
PHBLRRC590.713338706
PHBRAB340.713261303
PHBHSPA80.710615303
PHBMRPS230.707938806
PHBCCT40.7044981008
PHBORAI10.70402404
PHBIMP40.703329909
PHBPCBP20.703228605
PHBCACYBP0.703015908
PHBPSMD120.699054908
PHBVPS410.6958303
PHBTMEM2050.694239404
PHBBUB10.693263808
PHBNMT10.692977908

For details and further investigation, click here