| Full name: promyelocytic leukemia | Alias Symbol: MYL|TRIM19|RNF71 | ||
| Type: protein-coding gene | Cytoband: 15q24.1 | ||
| Entrez ID: 5371 | HGNC ID: HGNC:9113 | Ensembl Gene: ENSG00000140464 | OMIM ID: 102578 |
| Drug and gene relationship at DGIdb | |||
PML involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05200 | Pathways in cancer | |
| hsa05221 | Acute myeloid leukemia |
Expression of PML:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PML | 5371 | 211012_s_at | 0.7594 | 0.0547 | |
| GSE20347 | PML | 5371 | 211012_s_at | 0.4827 | 0.0046 | |
| GSE23400 | PML | 5371 | 211012_s_at | 0.1173 | 0.0744 | |
| GSE26886 | PML | 5371 | 211013_x_at | 0.5285 | 0.0466 | |
| GSE29001 | PML | 5371 | 211012_s_at | 0.2749 | 0.3447 | |
| GSE38129 | PML | 5371 | 211012_s_at | 0.3680 | 0.0068 | |
| GSE45670 | PML | 5371 | 235508_at | 0.5148 | 0.0137 | |
| GSE53622 | PML | 5371 | 23934 | 0.6057 | 0.0000 | |
| GSE53624 | PML | 5371 | 23934 | 0.6345 | 0.0000 | |
| GSE63941 | PML | 5371 | 211013_x_at | 0.3649 | 0.3440 | |
| GSE77861 | PML | 5371 | 211012_s_at | 0.1541 | 0.2624 | |
| GSE97050 | PML | 5371 | A_23_P358944 | 0.2811 | 0.4209 | |
| SRP007169 | PML | 5371 | RNAseq | 1.2446 | 0.0320 | |
| SRP008496 | PML | 5371 | RNAseq | 1.0971 | 0.0064 | |
| SRP064894 | PML | 5371 | RNAseq | 1.0669 | 0.0000 | |
| SRP133303 | PML | 5371 | RNAseq | 0.8799 | 0.0001 | |
| SRP159526 | PML | 5371 | RNAseq | 0.1676 | 0.5576 | |
| SRP193095 | PML | 5371 | RNAseq | 1.1270 | 0.0000 | |
| SRP219564 | PML | 5371 | RNAseq | 0.8563 | 0.0092 | |
| TCGA | PML | 5371 | RNAseq | 0.2763 | 0.0000 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by PML expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PML:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PML | 5371 | 9 | 0 | 21 | |
| GSE20123 | PML | 5371 | 9 | 0 | 21 | |
| GSE43470 | PML | 5371 | 4 | 6 | 33 | |
| GSE46452 | PML | 5371 | 3 | 7 | 49 | |
| GSE47630 | PML | 5371 | 8 | 10 | 22 | |
| GSE54993 | PML | 5371 | 5 | 6 | 59 | |
| GSE54994 | PML | 5371 | 5 | 7 | 41 | |
| GSE60625 | PML | 5371 | 4 | 0 | 7 | |
| GSE74703 | PML | 5371 | 4 | 3 | 29 | |
| GSE74704 | PML | 5371 | 5 | 0 | 15 | |
| TCGA | PML | 5371 | 13 | 15 | 68 |
Total number of gains: 69; Total number of losses: 54; Total Number of normals: 365.
Somatic mutations of PML:
Generating mutation plots.
Highly correlated genes for PML:
Showing top 20/490 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PML | CNTROB | 0.730723 | 4 | 0 | 4 |
| PML | C12orf45 | 0.714336 | 3 | 0 | 3 |
| PML | KLK3 | 0.683056 | 3 | 0 | 3 |
| PML | P4HA2 | 0.681619 | 3 | 0 | 3 |
| PML | SEMA4C | 0.66924 | 3 | 0 | 3 |
| PML | SLC6A3 | 0.663344 | 3 | 0 | 3 |
| PML | SLC25A31 | 0.660363 | 3 | 0 | 3 |
| PML | PRRX2 | 0.653664 | 4 | 0 | 4 |
| PML | CBX8 | 0.652313 | 3 | 0 | 3 |
| PML | TDRD1 | 0.6461 | 3 | 0 | 3 |
| PML | TUBGCP6 | 0.645863 | 3 | 0 | 3 |
| PML | CNGB3 | 0.640141 | 5 | 0 | 4 |
| PML | EPSTI1 | 0.63448 | 4 | 0 | 4 |
| PML | CT62 | 0.632442 | 3 | 0 | 3 |
| PML | FOXRED2 | 0.632151 | 4 | 0 | 3 |
| PML | APCS | 0.6311 | 3 | 0 | 3 |
| PML | RAPGEF1 | 0.630693 | 5 | 0 | 3 |
| PML | ACOT13 | 0.630432 | 3 | 0 | 3 |
| PML | C1QTNF1 | 0.628941 | 5 | 0 | 4 |
| PML | AGTRAP | 0.627616 | 5 | 0 | 4 |
For details and further investigation, click here
