| Full name: metabolism of cobalamin associated D | Alias Symbol: CL25022|cblD | ||
| Type: protein-coding gene | Cytoband: 2q23.2 | ||
| Entrez ID: 27249 | HGNC ID: HGNC:25221 | Ensembl Gene: ENSG00000168288 | OMIM ID: 611935 |
| Drug and gene relationship at DGIdb | |||
Expression of MMADHC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MMADHC | 27249 | 217883_at | -0.0528 | 0.9002 | |
| GSE20347 | MMADHC | 27249 | 217883_at | -0.3435 | 0.0540 | |
| GSE23400 | MMADHC | 27249 | 217883_at | -0.0964 | 0.2004 | |
| GSE26886 | MMADHC | 27249 | 217883_at | -0.6561 | 0.0031 | |
| GSE29001 | MMADHC | 27249 | 217883_at | -0.2956 | 0.3626 | |
| GSE38129 | MMADHC | 27249 | 217883_at | -0.0608 | 0.7022 | |
| GSE45670 | MMADHC | 27249 | 217883_at | 0.0137 | 0.9373 | |
| GSE53622 | MMADHC | 27249 | 103255 | -0.0337 | 0.5587 | |
| GSE53624 | MMADHC | 27249 | 103255 | -0.1223 | 0.0523 | |
| GSE63941 | MMADHC | 27249 | 217883_at | -0.8126 | 0.0529 | |
| GSE77861 | MMADHC | 27249 | 217883_at | -0.2824 | 0.2796 | |
| GSE97050 | MMADHC | 27249 | A_23_P94932 | 0.0904 | 0.7032 | |
| SRP007169 | MMADHC | 27249 | RNAseq | -0.9263 | 0.0125 | |
| SRP008496 | MMADHC | 27249 | RNAseq | -0.8293 | 0.0003 | |
| SRP064894 | MMADHC | 27249 | RNAseq | -0.3139 | 0.1365 | |
| SRP133303 | MMADHC | 27249 | RNAseq | 0.1086 | 0.3384 | |
| SRP159526 | MMADHC | 27249 | RNAseq | -0.3353 | 0.2680 | |
| SRP193095 | MMADHC | 27249 | RNAseq | -0.5737 | 0.0006 | |
| SRP219564 | MMADHC | 27249 | RNAseq | -0.7844 | 0.0105 | |
| TCGA | MMADHC | 27249 | RNAseq | 0.0159 | 0.7227 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MMADHC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MMADHC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MMADHC | 27249 | 3 | 3 | 24 | |
| GSE20123 | MMADHC | 27249 | 3 | 3 | 24 | |
| GSE43470 | MMADHC | 27249 | 3 | 1 | 39 | |
| GSE46452 | MMADHC | 27249 | 1 | 4 | 54 | |
| GSE47630 | MMADHC | 27249 | 5 | 3 | 32 | |
| GSE54993 | MMADHC | 27249 | 0 | 5 | 65 | |
| GSE54994 | MMADHC | 27249 | 11 | 2 | 40 | |
| GSE60625 | MMADHC | 27249 | 0 | 3 | 8 | |
| GSE74703 | MMADHC | 27249 | 2 | 1 | 33 | |
| GSE74704 | MMADHC | 27249 | 3 | 1 | 16 | |
| TCGA | MMADHC | 27249 | 21 | 8 | 67 |
Total number of gains: 52; Total number of losses: 34; Total Number of normals: 402.
Somatic mutations of MMADHC:
Generating mutation plots.
Highly correlated genes for MMADHC:
Showing top 20/668 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MMADHC | HSPA9 | 0.733752 | 3 | 0 | 3 |
| MMADHC | HERPUD1 | 0.728193 | 3 | 0 | 3 |
| MMADHC | PKN2 | 0.710443 | 3 | 0 | 3 |
| MMADHC | UBE2J1 | 0.694902 | 5 | 0 | 4 |
| MMADHC | PNP | 0.692945 | 4 | 0 | 4 |
| MMADHC | TM9SF3 | 0.692289 | 4 | 0 | 4 |
| MMADHC | SLC43A3 | 0.689772 | 3 | 0 | 3 |
| MMADHC | DCTN2 | 0.686393 | 3 | 0 | 3 |
| MMADHC | PPP2R5E | 0.685967 | 3 | 0 | 3 |
| MMADHC | SLC17A5 | 0.685625 | 4 | 0 | 4 |
| MMADHC | VPS29 | 0.671592 | 5 | 0 | 4 |
| MMADHC | TAB3 | 0.668944 | 3 | 0 | 3 |
| MMADHC | RASGRP1 | 0.662911 | 4 | 0 | 4 |
| MMADHC | SH3BGRL | 0.661749 | 5 | 0 | 4 |
| MMADHC | CCDC25 | 0.658297 | 3 | 0 | 3 |
| MMADHC | VPS25 | 0.656504 | 5 | 0 | 5 |
| MMADHC | SERINC1 | 0.65638 | 8 | 0 | 6 |
| MMADHC | TET2 | 0.655077 | 4 | 0 | 3 |
| MMADHC | RAB2A | 0.655012 | 6 | 0 | 5 |
| MMADHC | TSPYL1 | 0.654514 | 7 | 0 | 6 |
For details and further investigation, click here
