| Full name: uracil DNA glycosylase | Alias Symbol: UDG|UNG1|UNG2|HIGM4 | ||
| Type: protein-coding gene | Cytoband: 12q24.11 | ||
| Entrez ID: 7374 | HGNC ID: HGNC:12572 | Ensembl Gene: ENSG00000076248 | OMIM ID: 191525 |
| Drug and gene relationship at DGIdb | |||
Expression of UNG:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UNG | 7374 | 202330_s_at | 0.5886 | 0.2526 | |
| GSE20347 | UNG | 7374 | 202330_s_at | 0.4192 | 0.0040 | |
| GSE23400 | UNG | 7374 | 202330_s_at | 0.7419 | 0.0000 | |
| GSE26886 | UNG | 7374 | 202330_s_at | -0.2565 | 0.2439 | |
| GSE29001 | UNG | 7374 | 202330_s_at | 0.5034 | 0.0048 | |
| GSE38129 | UNG | 7374 | 202330_s_at | 0.7386 | 0.0000 | |
| GSE45670 | UNG | 7374 | 202330_s_at | 0.2302 | 0.0853 | |
| GSE53622 | UNG | 7374 | 43364 | 0.2947 | 0.0015 | |
| GSE53624 | UNG | 7374 | 43364 | 0.5202 | 0.0000 | |
| GSE63941 | UNG | 7374 | 202330_s_at | 1.2575 | 0.0051 | |
| GSE77861 | UNG | 7374 | 202330_s_at | 0.4436 | 0.0518 | |
| GSE97050 | UNG | 7374 | A_33_P3236157 | 0.2103 | 0.6021 | |
| SRP007169 | UNG | 7374 | RNAseq | 1.1553 | 0.0087 | |
| SRP008496 | UNG | 7374 | RNAseq | 0.7224 | 0.0113 | |
| SRP064894 | UNG | 7374 | RNAseq | 0.4512 | 0.0603 | |
| SRP133303 | UNG | 7374 | RNAseq | 0.3152 | 0.1604 | |
| SRP159526 | UNG | 7374 | RNAseq | 0.7058 | 0.0016 | |
| SRP193095 | UNG | 7374 | RNAseq | 0.0164 | 0.9076 | |
| SRP219564 | UNG | 7374 | RNAseq | 0.2157 | 0.5129 | |
| TCGA | UNG | 7374 | RNAseq | 0.2286 | 0.0001 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by UNG expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UNG:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UNG | 7374 | 5 | 3 | 22 | |
| GSE20123 | UNG | 7374 | 5 | 4 | 21 | |
| GSE43470 | UNG | 7374 | 2 | 1 | 40 | |
| GSE46452 | UNG | 7374 | 9 | 1 | 49 | |
| GSE47630 | UNG | 7374 | 9 | 1 | 30 | |
| GSE54993 | UNG | 7374 | 0 | 5 | 65 | |
| GSE54994 | UNG | 7374 | 3 | 3 | 47 | |
| GSE60625 | UNG | 7374 | 0 | 0 | 11 | |
| GSE74703 | UNG | 7374 | 2 | 0 | 34 | |
| GSE74704 | UNG | 7374 | 2 | 2 | 16 | |
| TCGA | UNG | 7374 | 21 | 10 | 65 |
Total number of gains: 58; Total number of losses: 30; Total Number of normals: 400.
Somatic mutations of UNG:
Generating mutation plots.
Highly correlated genes for UNG:
Showing top 20/1213 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UNG | LRRC58 | 0.786539 | 3 | 0 | 3 |
| UNG | LEMD2 | 0.771438 | 3 | 0 | 3 |
| UNG | TRMT5 | 0.767459 | 4 | 0 | 4 |
| UNG | STARD10 | 0.76582 | 3 | 0 | 3 |
| UNG | ZNRD1 | 0.754015 | 3 | 0 | 3 |
| UNG | ALG1 | 0.75293 | 4 | 0 | 3 |
| UNG | C8orf76 | 0.747354 | 3 | 0 | 3 |
| UNG | MRPL38 | 0.742835 | 4 | 0 | 4 |
| UNG | TP53RK | 0.727292 | 3 | 0 | 3 |
| UNG | THAP5 | 0.726298 | 3 | 0 | 3 |
| UNG | TMED8 | 0.724508 | 3 | 0 | 3 |
| UNG | RNF2 | 0.723819 | 3 | 0 | 3 |
| UNG | WIPI2 | 0.718343 | 3 | 0 | 3 |
| UNG | UHRF1BP1 | 0.715638 | 4 | 0 | 3 |
| UNG | POLDIP3 | 0.712842 | 3 | 0 | 3 |
| UNG | HMGN2 | 0.712805 | 5 | 0 | 5 |
| UNG | SNAPC5 | 0.707279 | 3 | 0 | 3 |
| UNG | HEATR6 | 0.70259 | 4 | 0 | 4 |
| UNG | TMEM63B | 0.701406 | 3 | 0 | 3 |
| UNG | SLC7A6 | 0.700414 | 3 | 0 | 3 |
For details and further investigation, click here
