| Full name: TIA1 cytotoxic granule associated RNA binding protein | Alias Symbol: TIA-1 | ||
| Type: protein-coding gene | Cytoband: 2p13.3 | ||
| Entrez ID: 7072 | HGNC ID: HGNC:11802 | Ensembl Gene: ENSG00000116001 | OMIM ID: 603518 |
| Drug and gene relationship at DGIdb | |||
Expression of TIA1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TIA1 | 7072 | 201448_at | 0.1225 | 0.8473 | |
| GSE20347 | TIA1 | 7072 | 201448_at | 0.3294 | 0.1561 | |
| GSE23400 | TIA1 | 7072 | 201446_s_at | 0.6632 | 0.0000 | |
| GSE26886 | TIA1 | 7072 | 201450_s_at | 0.3624 | 0.1172 | |
| GSE29001 | TIA1 | 7072 | 201448_at | 0.4244 | 0.0724 | |
| GSE38129 | TIA1 | 7072 | 201448_at | 0.3132 | 0.0607 | |
| GSE45670 | TIA1 | 7072 | 201448_at | 0.1801 | 0.4325 | |
| GSE53622 | TIA1 | 7072 | 63413 | 0.6427 | 0.0000 | |
| GSE53624 | TIA1 | 7072 | 63413 | 0.5762 | 0.0000 | |
| GSE63941 | TIA1 | 7072 | 201448_at | -0.4208 | 0.4742 | |
| GSE77861 | TIA1 | 7072 | 201446_s_at | 0.6689 | 0.0898 | |
| GSE97050 | TIA1 | 7072 | A_23_P90845 | 0.3543 | 0.2738 | |
| SRP007169 | TIA1 | 7072 | RNAseq | 0.3276 | 0.3837 | |
| SRP008496 | TIA1 | 7072 | RNAseq | 0.2497 | 0.4186 | |
| SRP064894 | TIA1 | 7072 | RNAseq | 0.3314 | 0.1177 | |
| SRP133303 | TIA1 | 7072 | RNAseq | 0.5438 | 0.0005 | |
| SRP159526 | TIA1 | 7072 | RNAseq | 0.5199 | 0.0924 | |
| SRP193095 | TIA1 | 7072 | RNAseq | 0.2782 | 0.0067 | |
| SRP219564 | TIA1 | 7072 | RNAseq | 0.1200 | 0.5915 | |
| TCGA | TIA1 | 7072 | RNAseq | 0.0221 | 0.6697 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TIA1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TIA1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TIA1 | 7072 | 11 | 1 | 18 | |
| GSE20123 | TIA1 | 7072 | 11 | 0 | 19 | |
| GSE43470 | TIA1 | 7072 | 3 | 0 | 40 | |
| GSE46452 | TIA1 | 7072 | 2 | 3 | 54 | |
| GSE47630 | TIA1 | 7072 | 7 | 0 | 33 | |
| GSE54993 | TIA1 | 7072 | 0 | 6 | 64 | |
| GSE54994 | TIA1 | 7072 | 11 | 0 | 42 | |
| GSE60625 | TIA1 | 7072 | 0 | 3 | 8 | |
| GSE74703 | TIA1 | 7072 | 3 | 0 | 33 | |
| GSE74704 | TIA1 | 7072 | 9 | 1 | 10 | |
| TCGA | TIA1 | 7072 | 36 | 2 | 58 |
Total number of gains: 93; Total number of losses: 16; Total Number of normals: 379.
Somatic mutations of TIA1:
Generating mutation plots.
Highly correlated genes for TIA1:
Showing top 20/910 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TIA1 | MRPL42 | 0.761895 | 3 | 0 | 3 |
| TIA1 | POLR2K | 0.753203 | 3 | 0 | 3 |
| TIA1 | USP14 | 0.737576 | 4 | 0 | 4 |
| TIA1 | DOCK7 | 0.731865 | 4 | 0 | 4 |
| TIA1 | SWT1 | 0.721614 | 3 | 0 | 3 |
| TIA1 | SMCR8 | 0.717244 | 3 | 0 | 3 |
| TIA1 | MAK16 | 0.715481 | 4 | 0 | 4 |
| TIA1 | SFXN4 | 0.714689 | 3 | 0 | 3 |
| TIA1 | G2E3 | 0.714043 | 3 | 0 | 3 |
| TIA1 | SMC2 | 0.711635 | 5 | 0 | 4 |
| TIA1 | ANKRD40 | 0.71123 | 3 | 0 | 3 |
| TIA1 | TAS2R43 | 0.710666 | 3 | 0 | 3 |
| TIA1 | UBR1 | 0.710029 | 3 | 0 | 3 |
| TIA1 | ZNF317 | 0.709794 | 3 | 0 | 3 |
| TIA1 | NMD3 | 0.705356 | 3 | 0 | 3 |
| TIA1 | SPRED1 | 0.704902 | 4 | 0 | 3 |
| TIA1 | ACAD11 | 0.703676 | 3 | 0 | 3 |
| TIA1 | TAS2R19 | 0.703012 | 4 | 0 | 4 |
| TIA1 | CSE1L | 0.702973 | 4 | 0 | 3 |
| TIA1 | FAM120B | 0.702214 | 3 | 0 | 3 |
For details and further investigation, click here
