| Full name: phospholipase A2 group VI | Alias Symbol: iPLA2|PNPLA9|PARK14|iPLA2beta|NBIA2 | ||
| Type: protein-coding gene | Cytoband: 22q13.1 | ||
| Entrez ID: 8398 | HGNC ID: HGNC:9039 | Ensembl Gene: ENSG00000184381 | OMIM ID: 603604 |
| Drug and gene relationship at DGIdb | |||
PLA2G6 involved pathways:
Expression of PLA2G6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLA2G6 | 8398 | 204691_x_at | -0.0441 | 0.8816 | |
| GSE20347 | PLA2G6 | 8398 | 210647_x_at | -0.0500 | 0.7142 | |
| GSE23400 | PLA2G6 | 8398 | 204691_x_at | -0.2162 | 0.0000 | |
| GSE26886 | PLA2G6 | 8398 | 204691_x_at | -0.0975 | 0.4291 | |
| GSE29001 | PLA2G6 | 8398 | 210647_x_at | -0.2734 | 0.1753 | |
| GSE38129 | PLA2G6 | 8398 | 204691_x_at | -0.0888 | 0.3628 | |
| GSE45670 | PLA2G6 | 8398 | 204691_x_at | -0.0070 | 0.9453 | |
| GSE53622 | PLA2G6 | 8398 | 32914 | 0.2631 | 0.0320 | |
| GSE53624 | PLA2G6 | 8398 | 32914 | -0.0287 | 0.7685 | |
| GSE63941 | PLA2G6 | 8398 | 204691_x_at | 0.6089 | 0.0073 | |
| GSE77861 | PLA2G6 | 8398 | 210647_x_at | 0.0419 | 0.7644 | |
| GSE97050 | PLA2G6 | 8398 | A_23_P6464 | 0.2029 | 0.4659 | |
| SRP007169 | PLA2G6 | 8398 | RNAseq | 0.7660 | 0.1971 | |
| SRP008496 | PLA2G6 | 8398 | RNAseq | 0.3703 | 0.4657 | |
| SRP064894 | PLA2G6 | 8398 | RNAseq | 0.1638 | 0.3375 | |
| SRP133303 | PLA2G6 | 8398 | RNAseq | -0.5641 | 0.0028 | |
| SRP159526 | PLA2G6 | 8398 | RNAseq | 0.5472 | 0.2359 | |
| SRP193095 | PLA2G6 | 8398 | RNAseq | 0.1515 | 0.4593 | |
| SRP219564 | PLA2G6 | 8398 | RNAseq | 0.0371 | 0.9085 | |
| TCGA | PLA2G6 | 8398 | RNAseq | -0.1063 | 0.1748 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PLA2G6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PLA2G6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLA2G6 | 8398 | 6 | 5 | 19 | |
| GSE20123 | PLA2G6 | 8398 | 6 | 4 | 20 | |
| GSE43470 | PLA2G6 | 8398 | 5 | 5 | 33 | |
| GSE46452 | PLA2G6 | 8398 | 32 | 2 | 25 | |
| GSE47630 | PLA2G6 | 8398 | 9 | 4 | 27 | |
| GSE54993 | PLA2G6 | 8398 | 3 | 6 | 61 | |
| GSE54994 | PLA2G6 | 8398 | 9 | 7 | 37 | |
| GSE60625 | PLA2G6 | 8398 | 5 | 0 | 6 | |
| GSE74703 | PLA2G6 | 8398 | 5 | 4 | 27 | |
| GSE74704 | PLA2G6 | 8398 | 3 | 2 | 15 | |
| TCGA | PLA2G6 | 8398 | 27 | 15 | 54 |
Total number of gains: 110; Total number of losses: 54; Total Number of normals: 324.
Somatic mutations of PLA2G6:
Generating mutation plots.
Highly correlated genes for PLA2G6:
Showing top 20/549 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLA2G6 | ASCL3 | 0.730438 | 4 | 0 | 4 |
| PLA2G6 | RGR | 0.712091 | 5 | 0 | 5 |
| PLA2G6 | ADAP1 | 0.700347 | 3 | 0 | 3 |
| PLA2G6 | MAGEB2 | 0.699651 | 3 | 0 | 3 |
| PLA2G6 | GTF2IRD2 | 0.673469 | 3 | 0 | 3 |
| PLA2G6 | MVK | 0.673019 | 6 | 0 | 6 |
| PLA2G6 | FGF21 | 0.67074 | 3 | 0 | 3 |
| PLA2G6 | CYP2D6 | 0.667021 | 6 | 0 | 6 |
| PLA2G6 | CNR2 | 0.66679 | 5 | 0 | 5 |
| PLA2G6 | HRC | 0.666059 | 5 | 0 | 5 |
| PLA2G6 | UBXN11 | 0.665855 | 4 | 0 | 4 |
| PLA2G6 | RGSL1 | 0.664559 | 4 | 0 | 3 |
| PLA2G6 | FGF23 | 0.663619 | 4 | 0 | 4 |
| PLA2G6 | AMHR2 | 0.65687 | 6 | 0 | 6 |
| PLA2G6 | MC2R | 0.65343 | 3 | 0 | 3 |
| PLA2G6 | GLP1R | 0.653143 | 5 | 0 | 5 |
| PLA2G6 | UBA1 | 0.652329 | 4 | 0 | 4 |
| PLA2G6 | ABHD11 | 0.65087 | 3 | 0 | 3 |
| PLA2G6 | RFPL3 | 0.650107 | 4 | 0 | 3 |
| PLA2G6 | SMR3B | 0.650048 | 3 | 0 | 3 |
For details and further investigation, click here
