| Full name: PDZ binding kinase | Alias Symbol: TOPK|FLJ14385|Nori-3|SPK|CT84 | ||
| Type: protein-coding gene | Cytoband: 8p21.1 | ||
| Entrez ID: 55872 | HGNC ID: HGNC:18282 | Ensembl Gene: ENSG00000168078 | OMIM ID: 611210 |
| Drug and gene relationship at DGIdb | |||
Expression of PBK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PBK | 55872 | 219148_at | 1.6551 | 0.0557 | |
| GSE20347 | PBK | 55872 | 219148_at | 1.9101 | 0.0000 | |
| GSE23400 | PBK | 55872 | 219148_at | 1.5890 | 0.0000 | |
| GSE26886 | PBK | 55872 | 219148_at | 0.2027 | 0.7093 | |
| GSE29001 | PBK | 55872 | 219148_at | 1.4022 | 0.0187 | |
| GSE38129 | PBK | 55872 | 219148_at | 2.3130 | 0.0000 | |
| GSE45670 | PBK | 55872 | 219148_at | 1.3323 | 0.0004 | |
| GSE53622 | PBK | 55872 | 69050 | 1.4531 | 0.0000 | |
| GSE53624 | PBK | 55872 | 69050 | 1.6737 | 0.0000 | |
| GSE63941 | PBK | 55872 | 219148_at | 3.2656 | 0.0004 | |
| GSE77861 | PBK | 55872 | 219148_at | 1.2976 | 0.0029 | |
| GSE97050 | PBK | 55872 | A_32_P62997 | 0.7043 | 0.2291 | |
| SRP007169 | PBK | 55872 | RNAseq | 1.1912 | 0.0267 | |
| SRP008496 | PBK | 55872 | RNAseq | 1.0247 | 0.0020 | |
| SRP064894 | PBK | 55872 | RNAseq | 1.1279 | 0.0003 | |
| SRP133303 | PBK | 55872 | RNAseq | 1.1462 | 0.0016 | |
| SRP159526 | PBK | 55872 | RNAseq | 0.9885 | 0.0005 | |
| SRP193095 | PBK | 55872 | RNAseq | 0.8356 | 0.0001 | |
| SRP219564 | PBK | 55872 | RNAseq | 1.1779 | 0.1440 | |
| TCGA | PBK | 55872 | RNAseq | 1.2247 | 0.0000 |
Upregulated datasets: 14; Downregulated datasets: 0.
Survival by PBK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PBK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PBK | 55872 | 6 | 10 | 14 | |
| GSE20123 | PBK | 55872 | 6 | 10 | 14 | |
| GSE43470 | PBK | 55872 | 4 | 7 | 32 | |
| GSE46452 | PBK | 55872 | 13 | 13 | 33 | |
| GSE47630 | PBK | 55872 | 10 | 8 | 22 | |
| GSE54993 | PBK | 55872 | 2 | 15 | 53 | |
| GSE54994 | PBK | 55872 | 10 | 15 | 28 | |
| GSE60625 | PBK | 55872 | 3 | 0 | 8 | |
| GSE74703 | PBK | 55872 | 4 | 6 | 26 | |
| GSE74704 | PBK | 55872 | 4 | 7 | 9 | |
| TCGA | PBK | 55872 | 16 | 42 | 38 |
Total number of gains: 78; Total number of losses: 133; Total Number of normals: 277.
Somatic mutations of PBK:
Generating mutation plots.
Highly correlated genes for PBK:
Showing top 20/1936 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PBK | CDCA2 | 0.842953 | 7 | 0 | 7 |
| PBK | CDK1 | 0.840547 | 12 | 0 | 12 |
| PBK | CCNB2 | 0.826787 | 12 | 0 | 12 |
| PBK | CEP55 | 0.82202 | 13 | 0 | 12 |
| PBK | BUB1B | 0.821082 | 10 | 0 | 9 |
| PBK | NEK2 | 0.819039 | 13 | 0 | 13 |
| PBK | BUB1 | 0.816036 | 11 | 0 | 11 |
| PBK | PRC1 | 0.806935 | 13 | 0 | 13 |
| PBK | HMMR | 0.806433 | 13 | 0 | 12 |
| PBK | GINS1 | 0.805212 | 12 | 0 | 11 |
| PBK | ESCO2 | 0.804691 | 8 | 0 | 8 |
| PBK | KIF11 | 0.802268 | 13 | 0 | 13 |
| PBK | MAD2L1 | 0.802161 | 13 | 0 | 13 |
| PBK | CDC20 | 0.800043 | 11 | 0 | 11 |
| PBK | ASPM | 0.799445 | 13 | 0 | 13 |
| PBK | NUSAP1 | 0.793952 | 13 | 0 | 13 |
| PBK | NUF2 | 0.793783 | 9 | 0 | 9 |
| PBK | NCAPG2 | 0.789294 | 11 | 0 | 11 |
| PBK | CDKN3 | 0.78829 | 13 | 0 | 12 |
| PBK | RAD51AP1 | 0.787777 | 13 | 0 | 13 |
For details and further investigation, click here
