RFC3

 

Full name: replication factor C subunit 3 Alias Symbol: RFC38|MGC5276
Type: protein-coding gene Cytoband: 13q13.2
Entrez ID: 5983 HGNC ID: HGNC:9971 Ensembl Gene: ENSG00000133119 OMIM ID: 600405
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of RFC3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 RFC3 5983 204127_at 0.9254 0.0176
GSE20347 RFC3 5983 204127_at 1.1389 0.0000
GSE23400 RFC3 5983 204127_at 1.0237 0.0000
GSE26886 RFC3 5983 204127_at 0.8333 0.0183
GSE29001 RFC3 5983 204127_at 1.0261 0.0061
GSE38129 RFC3 5983 204127_at 1.2894 0.0000
GSE45670 RFC3 5983 204127_at 0.5747 0.0184
GSE53622 RFC3 5983 144117 1.1076 0.0000
GSE53624 RFC3 5983 144117 1.2954 0.0000
GSE63941 RFC3 5983 204127_at 2.1589 0.0006
GSE77861 RFC3 5983 204127_at 0.8735 0.0555
GSE97050 RFC3 5983 A_23_P14193 0.8575 0.1936
SRP007169 RFC3 5983 RNAseq 0.9196 0.0458
SRP008496 RFC3 5983 RNAseq 0.8952 0.0209
SRP064894 RFC3 5983 RNAseq 0.7259 0.0114
SRP133303 RFC3 5983 RNAseq 0.9021 0.0015
SRP159526 RFC3 5983 RNAseq 0.6921 0.0590
SRP193095 RFC3 5983 RNAseq 0.7340 0.0000
SRP219564 RFC3 5983 RNAseq 0.2140 0.6524
TCGA RFC3 5983 RNAseq 0.5617 0.0000

Upregulated datasets: 7; Downregulated datasets: 0.  

 

Survival by RFC3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of RFC3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 RFC3 5983 0 15 15
GSE20123 RFC3 5983 0 14 16
GSE43470 RFC3 5983 2 13 28
GSE46452 RFC3 5983 0 33 26
GSE47630 RFC3 5983 2 27 11
GSE54993 RFC3 5983 12 2 56
GSE54994 RFC3 5983 2 15 36
GSE60625 RFC3 5983 0 3 8
GSE74703 RFC3 5983 2 10 24
GSE74704 RFC3 5983 0 12 8
TCGA RFC3 5983 8 37 51

Total number of gains: 28; Total number of losses: 181; Total Number of normals: 279.  

 

Somatic mutations of RFC3:

 

Generating mutation plots.

 

Highly correlated genes for RFC3:

 

Showing top 20/1936 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
RFC3MMS22L0.809459303
RFC3NCAPH0.799494909
RFC3MCM60.79819413012
RFC3NUF20.791505909
RFC3RAD51AP10.78740213013
RFC3BARD10.784997303
RFC3DTL0.77994513012
RFC3BUB10.77906811010
RFC3TTK0.77722212012
RFC3TPX20.77672113013
RFC3STARD100.775616303
RFC3NEK20.77499613013
RFC3BORA0.77257910010
RFC3GMNN0.77214913013
RFC3KIF140.77029913012
RFC3SPC250.76395311011
RFC3FEN10.7619451009
RFC3ASPM0.76124413013
RFC3ANAPC10.758934303
RFC3MTFR20.758435707

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