| Full name: inorganic pyrophosphatase 1 | Alias Symbol: SID6-8061|Ppase|IOPPP|PP1 | ||
| Type: protein-coding gene | Cytoband: 10q22.1 | ||
| Entrez ID: 5464 | HGNC ID: HGNC:9226 | Ensembl Gene: ENSG00000180817 | OMIM ID: 179030 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of PPA1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPA1 | 5464 | 217848_s_at | -0.0127 | 0.9776 | |
| GSE20347 | PPA1 | 5464 | 217848_s_at | -0.3655 | 0.0220 | |
| GSE23400 | PPA1 | 5464 | 217848_s_at | -0.0801 | 0.3383 | |
| GSE26886 | PPA1 | 5464 | 217848_s_at | -0.2817 | 0.0720 | |
| GSE29001 | PPA1 | 5464 | 217848_s_at | -0.4994 | 0.0806 | |
| GSE38129 | PPA1 | 5464 | 217848_s_at | -0.0010 | 0.9957 | |
| GSE45670 | PPA1 | 5464 | 217848_s_at | -0.1889 | 0.2079 | |
| GSE53622 | PPA1 | 5464 | 299 | -0.3638 | 0.0000 | |
| GSE53624 | PPA1 | 5464 | 299 | -0.3219 | 0.0006 | |
| GSE63941 | PPA1 | 5464 | 217848_s_at | 0.3705 | 0.2799 | |
| GSE77861 | PPA1 | 5464 | 217848_s_at | -0.4366 | 0.1722 | |
| GSE97050 | PPA1 | 5464 | A_33_P3271241 | 0.0486 | 0.9220 | |
| SRP007169 | PPA1 | 5464 | RNAseq | -1.6077 | 0.0002 | |
| SRP008496 | PPA1 | 5464 | RNAseq | -1.3532 | 0.0000 | |
| SRP064894 | PPA1 | 5464 | RNAseq | -0.7984 | 0.0000 | |
| SRP133303 | PPA1 | 5464 | RNAseq | 0.1443 | 0.4779 | |
| SRP159526 | PPA1 | 5464 | RNAseq | -0.4038 | 0.4400 | |
| SRP193095 | PPA1 | 5464 | RNAseq | -0.6306 | 0.0000 | |
| SRP219564 | PPA1 | 5464 | RNAseq | 0.3407 | 0.5471 | |
| TCGA | PPA1 | 5464 | RNAseq | 0.1219 | 0.0231 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by PPA1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPA1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPA1 | 5464 | 2 | 4 | 24 | |
| GSE20123 | PPA1 | 5464 | 2 | 3 | 25 | |
| GSE43470 | PPA1 | 5464 | 1 | 7 | 35 | |
| GSE46452 | PPA1 | 5464 | 0 | 11 | 48 | |
| GSE47630 | PPA1 | 5464 | 2 | 14 | 24 | |
| GSE54993 | PPA1 | 5464 | 7 | 0 | 63 | |
| GSE54994 | PPA1 | 5464 | 2 | 12 | 39 | |
| GSE60625 | PPA1 | 5464 | 0 | 0 | 11 | |
| GSE74703 | PPA1 | 5464 | 1 | 4 | 31 | |
| GSE74704 | PPA1 | 5464 | 1 | 1 | 18 | |
| TCGA | PPA1 | 5464 | 9 | 23 | 64 |
Total number of gains: 27; Total number of losses: 79; Total Number of normals: 382.
Somatic mutations of PPA1:
Generating mutation plots.
Highly correlated genes for PPA1:
Showing top 20/673 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPA1 | COMTD1 | 0.744491 | 3 | 0 | 3 |
| PPA1 | ANAPC16 | 0.74222 | 3 | 0 | 3 |
| PPA1 | TTC39C | 0.73028 | 3 | 0 | 3 |
| PPA1 | RNF135 | 0.722923 | 3 | 0 | 3 |
| PPA1 | MTCH2 | 0.720626 | 5 | 0 | 5 |
| PPA1 | NIPAL3 | 0.720511 | 3 | 0 | 3 |
| PPA1 | PCBD2 | 0.713687 | 3 | 0 | 3 |
| PPA1 | SCAMP2 | 0.712665 | 3 | 0 | 3 |
| PPA1 | RNF125 | 0.71143 | 3 | 0 | 3 |
| PPA1 | SLC37A4 | 0.706251 | 3 | 0 | 3 |
| PPA1 | RALGPS2 | 0.70349 | 4 | 0 | 3 |
| PPA1 | TRA2A | 0.696793 | 3 | 0 | 3 |
| PPA1 | TOMM5 | 0.693835 | 3 | 0 | 3 |
| PPA1 | EMP2 | 0.691261 | 5 | 0 | 5 |
| PPA1 | PTRHD1 | 0.687124 | 4 | 0 | 3 |
| PPA1 | NMNAT1 | 0.685961 | 3 | 0 | 3 |
| PPA1 | PGM1 | 0.684371 | 5 | 0 | 4 |
| PPA1 | ABCB10 | 0.683944 | 3 | 0 | 3 |
| PPA1 | RAD17 | 0.682093 | 3 | 0 | 3 |
| PPA1 | SLC9A6 | 0.682002 | 3 | 0 | 3 |
For details and further investigation, click here
