| Full name: PPFIA binding protein 1 | Alias Symbol: L2|hSGT2|hSgt2p|SGT2 | ||
| Type: protein-coding gene | Cytoband: 12p11.23-p11.22 | ||
| Entrez ID: 8496 | HGNC ID: HGNC:9249 | Ensembl Gene: ENSG00000110841 | OMIM ID: 603141 |
| Drug and gene relationship at DGIdb | |||
Expression of PPFIBP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPFIBP1 | 8496 | 203735_x_at | -0.6852 | 0.0965 | |
| GSE20347 | PPFIBP1 | 8496 | 214375_at | 0.2188 | 0.4477 | |
| GSE23400 | PPFIBP1 | 8496 | 203735_x_at | 0.1408 | 0.1730 | |
| GSE26886 | PPFIBP1 | 8496 | 203735_x_at | 0.0047 | 0.9879 | |
| GSE29001 | PPFIBP1 | 8496 | 214375_at | 0.3315 | 0.5869 | |
| GSE38129 | PPFIBP1 | 8496 | 214375_at | 0.2588 | 0.2440 | |
| GSE45670 | PPFIBP1 | 8496 | 214375_at | 0.1060 | 0.7184 | |
| GSE53622 | PPFIBP1 | 8496 | 122588 | 0.3115 | 0.0003 | |
| GSE53624 | PPFIBP1 | 8496 | 93207 | 0.2457 | 0.0126 | |
| GSE63941 | PPFIBP1 | 8496 | 203735_x_at | 0.8852 | 0.2189 | |
| GSE77861 | PPFIBP1 | 8496 | 214375_at | 0.5783 | 0.2860 | |
| GSE97050 | PPFIBP1 | 8496 | A_24_P811704 | 0.1482 | 0.7709 | |
| SRP007169 | PPFIBP1 | 8496 | RNAseq | 1.0683 | 0.0042 | |
| SRP008496 | PPFIBP1 | 8496 | RNAseq | 1.3597 | 0.0000 | |
| SRP064894 | PPFIBP1 | 8496 | RNAseq | 0.0866 | 0.7592 | |
| SRP133303 | PPFIBP1 | 8496 | RNAseq | 0.4949 | 0.0302 | |
| SRP159526 | PPFIBP1 | 8496 | RNAseq | -0.1113 | 0.6326 | |
| SRP193095 | PPFIBP1 | 8496 | RNAseq | 0.2540 | 0.0774 | |
| SRP219564 | PPFIBP1 | 8496 | RNAseq | -0.0637 | 0.8795 | |
| TCGA | PPFIBP1 | 8496 | RNAseq | -0.0023 | 0.9720 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by PPFIBP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPFIBP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPFIBP1 | 8496 | 11 | 1 | 18 | |
| GSE20123 | PPFIBP1 | 8496 | 11 | 1 | 18 | |
| GSE43470 | PPFIBP1 | 8496 | 10 | 4 | 29 | |
| GSE46452 | PPFIBP1 | 8496 | 10 | 1 | 48 | |
| GSE47630 | PPFIBP1 | 8496 | 14 | 0 | 26 | |
| GSE54993 | PPFIBP1 | 8496 | 0 | 9 | 61 | |
| GSE54994 | PPFIBP1 | 8496 | 11 | 2 | 40 | |
| GSE60625 | PPFIBP1 | 8496 | 0 | 1 | 10 | |
| GSE74703 | PPFIBP1 | 8496 | 9 | 3 | 24 | |
| GSE74704 | PPFIBP1 | 8496 | 6 | 1 | 13 | |
| TCGA | PPFIBP1 | 8496 | 44 | 6 | 46 |
Total number of gains: 126; Total number of losses: 29; Total Number of normals: 333.
Somatic mutations of PPFIBP1:
Generating mutation plots.
Highly correlated genes for PPFIBP1:
Showing top 20/82 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPFIBP1 | AEBP2 | 0.764025 | 3 | 0 | 3 |
| PPFIBP1 | FBXO36 | 0.736516 | 3 | 0 | 3 |
| PPFIBP1 | PTPRB | 0.705182 | 3 | 0 | 3 |
| PPFIBP1 | BBS7 | 0.702632 | 3 | 0 | 3 |
| PPFIBP1 | NCOR1 | 0.70155 | 3 | 0 | 3 |
| PPFIBP1 | ERVFRD-1 | 0.699072 | 3 | 0 | 3 |
| PPFIBP1 | YME1L1 | 0.696912 | 3 | 0 | 3 |
| PPFIBP1 | FAM168A | 0.694994 | 3 | 0 | 3 |
| PPFIBP1 | TNFRSF19 | 0.694684 | 4 | 0 | 3 |
| PPFIBP1 | MRPL10 | 0.693439 | 3 | 0 | 3 |
| PPFIBP1 | KLF7 | 0.68934 | 3 | 0 | 3 |
| PPFIBP1 | LRCH3 | 0.682412 | 3 | 0 | 3 |
| PPFIBP1 | EMG1 | 0.681488 | 3 | 0 | 3 |
| PPFIBP1 | FZD1 | 0.657039 | 4 | 0 | 3 |
| PPFIBP1 | MACF1 | 0.642688 | 3 | 0 | 3 |
| PPFIBP1 | MORF4L1 | 0.637284 | 4 | 0 | 4 |
| PPFIBP1 | IDS | 0.624097 | 4 | 0 | 3 |
| PPFIBP1 | ZNF319 | 0.62342 | 3 | 0 | 3 |
| PPFIBP1 | CRIM1 | 0.622481 | 4 | 0 | 3 |
| PPFIBP1 | CYP2B6 | 0.620485 | 4 | 0 | 3 |
For details and further investigation, click here
