| Full name: protein phosphatase, Mg2+/Mn2+ dependent 1H | Alias Symbol: KIAA1157|FLJ13253|NERPP-2C | ||
| Type: protein-coding gene | Cytoband: 12q14.1-q14.2 | ||
| Entrez ID: 57460 | HGNC ID: HGNC:18583 | Ensembl Gene: ENSG00000111110 | OMIM ID: 616016 |
| Drug and gene relationship at DGIdb | |||
Expression of PPM1H:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPM1H | 57460 | 212686_at | 0.6504 | 0.5220 | |
| GSE20347 | PPM1H | 57460 | 212686_at | 0.6735 | 0.0238 | |
| GSE23400 | PPM1H | 57460 | 212686_at | 0.2629 | 0.0002 | |
| GSE26886 | PPM1H | 57460 | 233911_s_at | 0.0834 | 0.5031 | |
| GSE29001 | PPM1H | 57460 | 212686_at | 1.1781 | 0.0543 | |
| GSE38129 | PPM1H | 57460 | 212686_at | 0.7755 | 0.0026 | |
| GSE45670 | PPM1H | 57460 | 212686_at | 0.3884 | 0.4988 | |
| GSE53622 | PPM1H | 57460 | 83131 | 0.6096 | 0.0046 | |
| GSE53624 | PPM1H | 57460 | 83131 | 0.7041 | 0.0018 | |
| GSE63941 | PPM1H | 57460 | 212686_at | 1.6301 | 0.0591 | |
| GSE97050 | PPM1H | 57460 | A_23_P391443 | 0.0499 | 0.8412 | |
| SRP007169 | PPM1H | 57460 | RNAseq | 4.9946 | 0.0000 | |
| SRP008496 | PPM1H | 57460 | RNAseq | 4.3512 | 0.0000 | |
| SRP064894 | PPM1H | 57460 | RNAseq | 0.6398 | 0.1510 | |
| SRP133303 | PPM1H | 57460 | RNAseq | 0.6055 | 0.1414 | |
| SRP159526 | PPM1H | 57460 | RNAseq | 2.7190 | 0.0000 | |
| SRP193095 | PPM1H | 57460 | RNAseq | 0.5965 | 0.2245 | |
| SRP219564 | PPM1H | 57460 | RNAseq | 1.5129 | 0.0161 | |
| TCGA | PPM1H | 57460 | RNAseq | -0.5238 | 0.0288 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by PPM1H expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPM1H:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPM1H | 57460 | 3 | 1 | 26 | |
| GSE20123 | PPM1H | 57460 | 3 | 1 | 26 | |
| GSE43470 | PPM1H | 57460 | 4 | 0 | 39 | |
| GSE46452 | PPM1H | 57460 | 10 | 0 | 49 | |
| GSE47630 | PPM1H | 57460 | 10 | 2 | 28 | |
| GSE54993 | PPM1H | 57460 | 0 | 5 | 65 | |
| GSE54994 | PPM1H | 57460 | 5 | 2 | 46 | |
| GSE60625 | PPM1H | 57460 | 0 | 0 | 11 | |
| GSE74703 | PPM1H | 57460 | 4 | 0 | 32 | |
| GSE74704 | PPM1H | 57460 | 2 | 1 | 17 | |
| TCGA | PPM1H | 57460 | 17 | 9 | 70 |
Total number of gains: 58; Total number of losses: 21; Total Number of normals: 409.
Somatic mutations of PPM1H:
Generating mutation plots.
Highly correlated genes for PPM1H:
Showing top 20/136 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPM1H | KCNE3 | 0.687259 | 3 | 0 | 3 |
| PPM1H | MAGEA10 | 0.666598 | 3 | 0 | 3 |
| PPM1H | PPP1R9A | 0.647267 | 3 | 0 | 3 |
| PPM1H | CASKIN2 | 0.644358 | 3 | 0 | 3 |
| PPM1H | CHKA | 0.629668 | 5 | 0 | 4 |
| PPM1H | PPP5C | 0.618059 | 4 | 0 | 3 |
| PPM1H | FIZ1 | 0.607427 | 3 | 0 | 3 |
| PPM1H | NOXRED1 | 0.606352 | 3 | 0 | 3 |
| PPM1H | PPFIA1 | 0.606284 | 5 | 0 | 4 |
| PPM1H | PIK3R3 | 0.605273 | 5 | 0 | 3 |
| PPM1H | GHDC | 0.603127 | 3 | 0 | 3 |
| PPM1H | KLHL24 | 0.601052 | 5 | 0 | 4 |
| PPM1H | STAG1 | 0.599795 | 3 | 0 | 3 |
| PPM1H | TAF6 | 0.599225 | 4 | 0 | 3 |
| PPM1H | SLC9A2 | 0.598503 | 3 | 0 | 3 |
| PPM1H | PLCH1 | 0.594562 | 7 | 0 | 7 |
| PPM1H | RNMT | 0.586208 | 5 | 0 | 3 |
| PPM1H | ZNF627 | 0.582904 | 3 | 0 | 3 |
| PPM1H | DNAJC11 | 0.581441 | 3 | 0 | 3 |
| PPM1H | PIP5K1B | 0.580865 | 9 | 0 | 5 |
For details and further investigation, click here
