| Full name: WD repeat domain 3 | Alias Symbol: FLJ12796|UTP12|DIP2 | ||
| Type: protein-coding gene | Cytoband: 1p12 | ||
| Entrez ID: 10885 | HGNC ID: HGNC:12755 | Ensembl Gene: ENSG00000065183 | OMIM ID: 604737 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of WDR3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | WDR3 | 10885 | 218882_s_at | 0.4998 | 0.2505 | |
| GSE20347 | WDR3 | 10885 | 218882_s_at | 0.3197 | 0.0466 | |
| GSE23400 | WDR3 | 10885 | 218882_s_at | 0.4722 | 0.0000 | |
| GSE26886 | WDR3 | 10885 | 218882_s_at | 0.3373 | 0.0926 | |
| GSE29001 | WDR3 | 10885 | 218882_s_at | 0.2449 | 0.3194 | |
| GSE38129 | WDR3 | 10885 | 218882_s_at | 0.4892 | 0.0004 | |
| GSE45670 | WDR3 | 10885 | 218882_s_at | 0.2956 | 0.0456 | |
| GSE53622 | WDR3 | 10885 | 34956 | 0.3527 | 0.0000 | |
| GSE53624 | WDR3 | 10885 | 54132 | 0.4385 | 0.0000 | |
| GSE63941 | WDR3 | 10885 | 218882_s_at | 0.6322 | 0.2458 | |
| GSE77861 | WDR3 | 10885 | 218882_s_at | 0.2199 | 0.5088 | |
| GSE97050 | WDR3 | 10885 | A_33_P3211633 | 0.6305 | 0.3108 | |
| SRP007169 | WDR3 | 10885 | RNAseq | 0.8694 | 0.0996 | |
| SRP008496 | WDR3 | 10885 | RNAseq | 0.5770 | 0.0899 | |
| SRP064894 | WDR3 | 10885 | RNAseq | 0.0573 | 0.8041 | |
| SRP133303 | WDR3 | 10885 | RNAseq | 0.1909 | 0.1379 | |
| SRP159526 | WDR3 | 10885 | RNAseq | -0.3181 | 0.1921 | |
| SRP193095 | WDR3 | 10885 | RNAseq | -0.0086 | 0.9331 | |
| SRP219564 | WDR3 | 10885 | RNAseq | 0.0099 | 0.9848 | |
| TCGA | WDR3 | 10885 | RNAseq | 0.0643 | 0.3129 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by WDR3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of WDR3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | WDR3 | 10885 | 0 | 8 | 22 | |
| GSE20123 | WDR3 | 10885 | 0 | 8 | 22 | |
| GSE43470 | WDR3 | 10885 | 0 | 3 | 40 | |
| GSE46452 | WDR3 | 10885 | 2 | 1 | 56 | |
| GSE47630 | WDR3 | 10885 | 9 | 5 | 26 | |
| GSE54993 | WDR3 | 10885 | 0 | 1 | 69 | |
| GSE54994 | WDR3 | 10885 | 11 | 1 | 41 | |
| GSE60625 | WDR3 | 10885 | 0 | 0 | 11 | |
| GSE74703 | WDR3 | 10885 | 0 | 3 | 33 | |
| GSE74704 | WDR3 | 10885 | 0 | 4 | 16 | |
| TCGA | WDR3 | 10885 | 15 | 28 | 53 |
Total number of gains: 37; Total number of losses: 62; Total Number of normals: 389.
Somatic mutations of WDR3:
Generating mutation plots.
Highly correlated genes for WDR3:
Showing top 20/853 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| WDR3 | KDM1B | 0.752583 | 3 | 0 | 3 |
| WDR3 | IFT80 | 0.728772 | 3 | 0 | 3 |
| WDR3 | AP1G1 | 0.713936 | 3 | 0 | 3 |
| WDR3 | PPP2R1B | 0.713335 | 4 | 0 | 3 |
| WDR3 | CLCN5 | 0.712686 | 3 | 0 | 3 |
| WDR3 | SMARCAD1 | 0.709735 | 3 | 0 | 3 |
| WDR3 | INTS12 | 0.698885 | 3 | 0 | 3 |
| WDR3 | INTS10 | 0.684325 | 4 | 0 | 3 |
| WDR3 | EXOSC3 | 0.675275 | 5 | 0 | 3 |
| WDR3 | STAG1 | 0.674852 | 4 | 0 | 4 |
| WDR3 | BTF3L4 | 0.67471 | 3 | 0 | 3 |
| WDR3 | TMTC3 | 0.673761 | 3 | 0 | 3 |
| WDR3 | CDC42SE1 | 0.673244 | 4 | 0 | 3 |
| WDR3 | RAD18 | 0.671166 | 3 | 0 | 3 |
| WDR3 | FARSA | 0.660076 | 8 | 0 | 7 |
| WDR3 | TMEM170A | 0.657696 | 5 | 0 | 4 |
| WDR3 | POLR2C | 0.656527 | 3 | 0 | 3 |
| WDR3 | HERPUD2 | 0.655036 | 3 | 0 | 3 |
| WDR3 | ZCCHC7 | 0.652743 | 3 | 0 | 3 |
| WDR3 | TTF2 | 0.649528 | 11 | 0 | 10 |
For details and further investigation, click here
