| Full name: S100 calcium binding protein A12 | Alias Symbol: p6|MRP6|CGRP|CAAF1|CAGC|ENRAGE | ||
| Type: protein-coding gene | Cytoband: 1q21.3 | ||
| Entrez ID: 6283 | HGNC ID: HGNC:10489 | Ensembl Gene: ENSG00000163221 | OMIM ID: 603112 |
| Drug and gene relationship at DGIdb | |||
Expression of S100A12:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | S100A12 | 6283 | 205863_at | 0.0437 | 0.9891 | |
| GSE20347 | S100A12 | 6283 | 205863_at | -1.8557 | 0.0144 | |
| GSE23400 | S100A12 | 6283 | 205863_at | -1.2162 | 0.0000 | |
| GSE26886 | S100A12 | 6283 | 205863_at | -3.8836 | 0.0000 | |
| GSE29001 | S100A12 | 6283 | 205863_at | -2.1801 | 0.0085 | |
| GSE38129 | S100A12 | 6283 | 205863_at | -1.4384 | 0.0432 | |
| GSE45670 | S100A12 | 6283 | 205863_at | 1.3064 | 0.0042 | |
| GSE53622 | S100A12 | 6283 | 64033 | -0.4971 | 0.1212 | |
| GSE53624 | S100A12 | 6283 | 64033 | -1.5282 | 0.0000 | |
| GSE63941 | S100A12 | 6283 | 205863_at | 0.4420 | 0.3910 | |
| GSE77861 | S100A12 | 6283 | 205863_at | -0.7122 | 0.3259 | |
| GSE97050 | S100A12 | 6283 | A_23_P74001 | 0.0627 | 0.9516 | |
| SRP007169 | S100A12 | 6283 | RNAseq | -3.7899 | 0.0002 | |
| SRP008496 | S100A12 | 6283 | RNAseq | -2.3287 | 0.0259 | |
| SRP064894 | S100A12 | 6283 | RNAseq | -1.0596 | 0.0421 | |
| SRP133303 | S100A12 | 6283 | RNAseq | -1.1226 | 0.0281 | |
| SRP159526 | S100A12 | 6283 | RNAseq | -1.6481 | 0.0811 | |
| SRP219564 | S100A12 | 6283 | RNAseq | -2.9634 | 0.0048 | |
| TCGA | S100A12 | 6283 | RNAseq | 1.1068 | 0.0052 |
Upregulated datasets: 2; Downregulated datasets: 11.
Survival by S100A12 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of S100A12:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | S100A12 | 6283 | 14 | 0 | 16 | |
| GSE20123 | S100A12 | 6283 | 14 | 0 | 16 | |
| GSE43470 | S100A12 | 6283 | 6 | 2 | 35 | |
| GSE46452 | S100A12 | 6283 | 2 | 1 | 56 | |
| GSE47630 | S100A12 | 6283 | 15 | 0 | 25 | |
| GSE54993 | S100A12 | 6283 | 0 | 4 | 66 | |
| GSE54994 | S100A12 | 6283 | 16 | 0 | 37 | |
| GSE60625 | S100A12 | 6283 | 0 | 0 | 11 | |
| GSE74703 | S100A12 | 6283 | 6 | 1 | 29 | |
| GSE74704 | S100A12 | 6283 | 7 | 0 | 13 | |
| TCGA | S100A12 | 6283 | 40 | 2 | 54 |
Total number of gains: 120; Total number of losses: 10; Total Number of normals: 358.
Somatic mutations of S100A12:
Generating mutation plots.
Highly correlated genes for S100A12:
Showing top 20/787 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| S100A12 | S100A9 | 0.768856 | 11 | 0 | 11 |
| S100A12 | GJB6 | 0.751982 | 6 | 0 | 6 |
| S100A12 | ITGAD | 0.748338 | 3 | 0 | 3 |
| S100A12 | SBSN | 0.746002 | 6 | 0 | 6 |
| S100A12 | SPRR2A | 0.743856 | 3 | 0 | 3 |
| S100A12 | SPRR2B | 0.737672 | 4 | 0 | 4 |
| S100A12 | SPRR1B | 0.730812 | 12 | 0 | 11 |
| S100A12 | TMEM45B | 0.729281 | 6 | 0 | 6 |
| S100A12 | TGM1 | 0.726112 | 11 | 0 | 11 |
| S100A12 | IL36RN | 0.724097 | 10 | 0 | 9 |
| S100A12 | SERPINB3 | 0.720765 | 7 | 0 | 6 |
| S100A12 | LYPD3 | 0.712324 | 11 | 0 | 10 |
| S100A12 | FUT2 | 0.709512 | 8 | 0 | 7 |
| S100A12 | METRNL | 0.70889 | 6 | 0 | 6 |
| S100A12 | ZNF185 | 0.707515 | 10 | 0 | 10 |
| S100A12 | S100A8 | 0.702748 | 11 | 0 | 11 |
| S100A12 | CNFN | 0.702458 | 6 | 0 | 5 |
| S100A12 | PDZK1IP1 | 0.701777 | 12 | 0 | 12 |
| S100A12 | IVL | 0.700329 | 10 | 0 | 10 |
| S100A12 | TREX2 | 0.695476 | 3 | 0 | 3 |
For details and further investigation, click here
