| Full name: pancreatic polypeptide | Alias Symbol: PNP | ||
| Type: protein-coding gene | Cytoband: 17q21.31 | ||
| Entrez ID: 5539 | HGNC ID: HGNC:9327 | Ensembl Gene: ENSG00000108849 | OMIM ID: 167780 |
| Drug and gene relationship at DGIdb | |||
Expression of PPY:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPY | 5539 | 210670_at | -0.0829 | 0.7476 | |
| GSE20347 | PPY | 5539 | 210670_at | -0.0964 | 0.1427 | |
| GSE23400 | PPY | 5539 | 210670_at | -0.1556 | 0.0001 | |
| GSE26886 | PPY | 5539 | 210670_at | -0.0861 | 0.3525 | |
| GSE29001 | PPY | 5539 | 210670_at | -0.1704 | 0.1151 | |
| GSE38129 | PPY | 5539 | 210670_at | -0.1707 | 0.0042 | |
| GSE45670 | PPY | 5539 | 210670_at | 0.1000 | 0.3348 | |
| GSE53622 | PPY | 5539 | 68044 | -0.1118 | 0.3542 | |
| GSE53624 | PPY | 5539 | 68044 | -0.1118 | 0.1994 | |
| GSE63941 | PPY | 5539 | 210670_at | 0.0586 | 0.7160 | |
| GSE77861 | PPY | 5539 | 210670_at | -0.1305 | 0.2845 | |
| GSE97050 | PPY | 5539 | A_23_P207336 | -0.7535 | 0.1889 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PPY expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPY:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPY | 5539 | 5 | 2 | 23 | |
| GSE20123 | PPY | 5539 | 5 | 2 | 23 | |
| GSE43470 | PPY | 5539 | 1 | 2 | 40 | |
| GSE46452 | PPY | 5539 | 32 | 0 | 27 | |
| GSE47630 | PPY | 5539 | 8 | 1 | 31 | |
| GSE54993 | PPY | 5539 | 3 | 4 | 63 | |
| GSE54994 | PPY | 5539 | 8 | 6 | 39 | |
| GSE60625 | PPY | 5539 | 4 | 0 | 7 | |
| GSE74703 | PPY | 5539 | 1 | 1 | 34 | |
| GSE74704 | PPY | 5539 | 3 | 1 | 16 | |
| TCGA | PPY | 5539 | 23 | 7 | 66 |
Total number of gains: 93; Total number of losses: 26; Total Number of normals: 369.
Somatic mutations of PPY:
Generating mutation plots.
Highly correlated genes for PPY:
Showing top 20/312 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPY | GADD45GIP1 | 0.753727 | 3 | 0 | 3 |
| PPY | FAM71A | 0.657516 | 3 | 0 | 3 |
| PPY | LMOD3 | 0.646001 | 4 | 0 | 4 |
| PPY | CLCNKB | 0.642199 | 4 | 0 | 4 |
| PPY | REG1A | 0.635997 | 3 | 0 | 3 |
| PPY | GJA3 | 0.614913 | 4 | 0 | 3 |
| PPY | HUNK | 0.614067 | 3 | 0 | 3 |
| PPY | LINC00930 | 0.611811 | 3 | 0 | 3 |
| PPY | NLRC3 | 0.611369 | 3 | 0 | 3 |
| PPY | INS | 0.60997 | 5 | 0 | 3 |
| PPY | BARHL1 | 0.609378 | 3 | 0 | 3 |
| PPY | GPR17 | 0.60875 | 6 | 0 | 4 |
| PPY | RBMXL2 | 0.605382 | 4 | 0 | 3 |
| PPY | CPA2 | 0.604311 | 5 | 0 | 5 |
| PPY | PRM1 | 0.603597 | 5 | 0 | 5 |
| PPY | GSG1 | 0.601948 | 6 | 0 | 4 |
| PPY | C8A | 0.601436 | 3 | 0 | 3 |
| PPY | GREB1L | 0.599979 | 4 | 0 | 4 |
| PPY | APOA2 | 0.598595 | 5 | 0 | 4 |
| PPY | SPP2 | 0.597188 | 4 | 0 | 3 |
For details and further investigation, click here
