ZFP36L1

 

Full name: ZFP36 ring finger protein like 1 Alias Symbol: RNF162B|Berg36|ERF1|TIS11B|cMG1
Type: protein-coding gene Cytoband: 14q24.1
Entrez ID: 677 HGNC ID: HGNC:1107 Ensembl Gene: ENSG00000185650 OMIM ID: 601064
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 22/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of ZFP36L1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ZFP36L1 677 211962_s_at -0.1828 0.6816
GSE20347 ZFP36L1 677 211962_s_at -0.2816 0.1997
GSE23400 ZFP36L1 677 211962_s_at -0.0831 0.4055
GSE26886 ZFP36L1 677 211962_s_at -0.1074 0.6643
GSE29001 ZFP36L1 677 211962_s_at -0.2085 0.2038
GSE38129 ZFP36L1 677 211962_s_at -0.3139 0.0444
GSE45670 ZFP36L1 677 211962_s_at -0.2170 0.1232
GSE53622 ZFP36L1 677 94448 -0.1432 0.1525
GSE53624 ZFP36L1 677 84237 -0.2194 0.0005
GSE63941 ZFP36L1 677 211962_s_at -1.1951 0.0308
GSE77861 ZFP36L1 677 211962_s_at -0.3223 0.1234
GSE97050 ZFP36L1 677 A_33_P3417865 -0.4552 0.1662
SRP007169 ZFP36L1 677 RNAseq -0.4623 0.2021
SRP008496 ZFP36L1 677 RNAseq -0.0706 0.7649
SRP064894 ZFP36L1 677 RNAseq -0.2790 0.2420
SRP133303 ZFP36L1 677 RNAseq -0.1598 0.4744
SRP159526 ZFP36L1 677 RNAseq -0.5296 0.0834
SRP193095 ZFP36L1 677 RNAseq 0.0782 0.6556
SRP219564 ZFP36L1 677 RNAseq 0.4037 0.3321
TCGA ZFP36L1 677 RNAseq 0.0551 0.3029

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by ZFP36L1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ZFP36L1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ZFP36L1 677 8 2 20
GSE20123 ZFP36L1 677 8 2 20
GSE43470 ZFP36L1 677 8 2 33
GSE46452 ZFP36L1 677 16 3 40
GSE47630 ZFP36L1 677 11 9 20
GSE54993 ZFP36L1 677 3 9 58
GSE54994 ZFP36L1 677 18 5 30
GSE60625 ZFP36L1 677 0 2 9
GSE74703 ZFP36L1 677 7 2 27
GSE74704 ZFP36L1 677 3 2 15
TCGA ZFP36L1 677 32 16 48

Total number of gains: 114; Total number of losses: 54; Total Number of normals: 320.  

 

Somatic mutations of ZFP36L1:

 

Generating mutation plots.

 

Highly correlated genes for ZFP36L1:

 

Showing top 20/199 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ZFP36L1AFF30.728016303
ZFP36L1ACAA20.724992303
ZFP36L1RNF100.700437403
ZFP36L1LAPTM4A0.700418303
ZFP36L1GPRASP10.699192303
ZFP36L1NFIX0.695856303
ZFP36L1BOC0.689876303
ZFP36L1HERPUD20.686251303
ZFP36L1DCTN20.685923303
ZFP36L1PDGFD0.672566303
ZFP36L1ZFYVE90.669894303
ZFP36L1PRDM50.667294303
ZFP36L1HSPA20.661018404
ZFP36L1PORCN0.65915303
ZFP36L1NEK70.653425404
ZFP36L1COL21A10.652356303
ZFP36L1PIK3C30.651594303
ZFP36L1SLC28A20.649482303
ZFP36L1PRDX60.649094303
ZFP36L1FAM172A0.64897403

For details and further investigation, click here