| Full name: proteoglycan 2, pro eosinophil major basic protein | Alias Symbol: MBP|BMPG|proMBP | ||
| Type: protein-coding gene | Cytoband: 11q12.1 | ||
| Entrez ID: 5553 | HGNC ID: HGNC:9362 | Ensembl Gene: ENSG00000186652 | OMIM ID: 605601 |
| Drug and gene relationship at DGIdb | |||
Expression of PRG2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRG2 | 5553 | 211743_s_at | -0.3294 | 0.1852 | |
| GSE20347 | PRG2 | 5553 | 211743_s_at | -0.1919 | 0.0141 | |
| GSE23400 | PRG2 | 5553 | 211743_s_at | -0.0942 | 0.0021 | |
| GSE26886 | PRG2 | 5553 | 211743_s_at | -0.1343 | 0.3089 | |
| GSE29001 | PRG2 | 5553 | 211743_s_at | -0.5167 | 0.0022 | |
| GSE38129 | PRG2 | 5553 | 211743_s_at | -0.2390 | 0.0072 | |
| GSE45670 | PRG2 | 5553 | 211743_s_at | -0.2079 | 0.0343 | |
| GSE53622 | PRG2 | 5553 | 114363 | -0.4116 | 0.0016 | |
| GSE53624 | PRG2 | 5553 | 151009 | -0.7408 | 0.0000 | |
| GSE63941 | PRG2 | 5553 | 211743_s_at | 0.2062 | 0.1086 | |
| GSE77861 | PRG2 | 5553 | 211743_s_at | -0.0117 | 0.9439 | |
| GSE97050 | PRG2 | 5553 | A_23_P218002 | 0.1120 | 0.6651 | |
| SRP064894 | PRG2 | 5553 | RNAseq | -0.2904 | 0.4113 | |
| SRP133303 | PRG2 | 5553 | RNAseq | -1.3744 | 0.0004 | |
| SRP159526 | PRG2 | 5553 | RNAseq | -0.4371 | 0.6338 | |
| SRP219564 | PRG2 | 5553 | RNAseq | -0.5732 | 0.2265 | |
| TCGA | PRG2 | 5553 | RNAseq | -0.2472 | 0.5574 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by PRG2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PRG2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRG2 | 5553 | 2 | 3 | 25 | |
| GSE20123 | PRG2 | 5553 | 2 | 3 | 25 | |
| GSE43470 | PRG2 | 5553 | 1 | 5 | 37 | |
| GSE46452 | PRG2 | 5553 | 8 | 4 | 47 | |
| GSE47630 | PRG2 | 5553 | 3 | 9 | 28 | |
| GSE54993 | PRG2 | 5553 | 3 | 0 | 67 | |
| GSE54994 | PRG2 | 5553 | 5 | 6 | 42 | |
| GSE60625 | PRG2 | 5553 | 0 | 3 | 8 | |
| GSE74703 | PRG2 | 5553 | 1 | 3 | 32 | |
| GSE74704 | PRG2 | 5553 | 2 | 3 | 15 | |
| TCGA | PRG2 | 5553 | 14 | 10 | 72 |
Total number of gains: 41; Total number of losses: 49; Total Number of normals: 398.
Somatic mutations of PRG2:
Generating mutation plots.
Highly correlated genes for PRG2:
Showing top 20/429 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRG2 | TULP3 | 0.783259 | 3 | 0 | 3 |
| PRG2 | RASGRP4 | 0.763788 | 3 | 0 | 3 |
| PRG2 | CLCN1 | 0.727825 | 3 | 0 | 3 |
| PRG2 | FAM171A2 | 0.693287 | 3 | 0 | 3 |
| PRG2 | PRSS54 | 0.688327 | 4 | 0 | 3 |
| PRG2 | DOK7 | 0.677769 | 3 | 0 | 3 |
| PRG2 | SPEF2 | 0.671995 | 3 | 0 | 3 |
| PRG2 | OR2H2 | 0.667582 | 6 | 0 | 6 |
| PRG2 | POU1F1 | 0.66735 | 4 | 0 | 3 |
| PRG2 | C11orf86 | 0.66679 | 4 | 0 | 3 |
| PRG2 | TESC | 0.66567 | 4 | 0 | 3 |
| PRG2 | GALR3 | 0.66324 | 7 | 0 | 6 |
| PRG2 | HAAO | 0.65956 | 8 | 0 | 8 |
| PRG2 | AMHR2 | 0.6558 | 6 | 0 | 6 |
| PRG2 | MAP3K10 | 0.649093 | 7 | 0 | 6 |
| PRG2 | PTCRA | 0.64894 | 8 | 0 | 7 |
| PRG2 | RGR | 0.641426 | 7 | 0 | 5 |
| PRG2 | KCNQ1 | 0.638469 | 6 | 0 | 5 |
| PRG2 | CRHR2 | 0.636902 | 4 | 0 | 3 |
| PRG2 | GPR17 | 0.634426 | 5 | 0 | 4 |
For details and further investigation, click here
