| Full name: RAS guanyl releasing protein 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 19q13.1 | ||
| Entrez ID: 115727 | HGNC ID: HGNC:18958 | Ensembl Gene: ENSG00000171777 | OMIM ID: 607320 |
RASGRP4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway | |
| hsa04014 | Ras signaling pathway |
Expression of RASGRP4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RASGRP4 | 115727 | 240862_at | -0.1004 | 0.6680 | |
| GSE26886 | RASGRP4 | 115727 | 240862_at | -0.1102 | 0.2754 | |
| GSE45670 | RASGRP4 | 115727 | 240862_at | 0.0984 | 0.3466 | |
| GSE53622 | RASGRP4 | 115727 | 144581 | -0.0503 | 0.5582 | |
| GSE53624 | RASGRP4 | 115727 | 144581 | -0.0166 | 0.8212 | |
| GSE63941 | RASGRP4 | 115727 | 240862_at | 0.2127 | 0.1198 | |
| GSE77861 | RASGRP4 | 115727 | 240862_at | 0.1217 | 0.1654 | |
| GSE97050 | RASGRP4 | 115727 | A_23_P165007 | 0.1594 | 0.6094 | |
| SRP064894 | RASGRP4 | 115727 | RNAseq | -0.0862 | 0.7803 | |
| SRP133303 | RASGRP4 | 115727 | RNAseq | -0.2926 | 0.1259 | |
| SRP159526 | RASGRP4 | 115727 | RNAseq | -0.0127 | 0.9825 | |
| SRP193095 | RASGRP4 | 115727 | RNAseq | 0.4907 | 0.0047 | |
| SRP219564 | RASGRP4 | 115727 | RNAseq | 0.5308 | 0.3252 | |
| TCGA | RASGRP4 | 115727 | RNAseq | -0.4200 | 0.0513 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by RASGRP4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RASGRP4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RASGRP4 | 115727 | 7 | 4 | 19 | |
| GSE20123 | RASGRP4 | 115727 | 7 | 3 | 20 | |
| GSE43470 | RASGRP4 | 115727 | 4 | 10 | 29 | |
| GSE46452 | RASGRP4 | 115727 | 47 | 2 | 10 | |
| GSE47630 | RASGRP4 | 115727 | 9 | 5 | 26 | |
| GSE54993 | RASGRP4 | 115727 | 17 | 3 | 50 | |
| GSE54994 | RASGRP4 | 115727 | 6 | 9 | 38 | |
| GSE60625 | RASGRP4 | 115727 | 9 | 0 | 2 | |
| GSE74703 | RASGRP4 | 115727 | 4 | 6 | 26 | |
| GSE74704 | RASGRP4 | 115727 | 7 | 1 | 12 | |
| TCGA | RASGRP4 | 115727 | 16 | 15 | 65 |
Total number of gains: 133; Total number of losses: 58; Total Number of normals: 297.
Somatic mutations of RASGRP4:
Generating mutation plots.
Highly correlated genes for RASGRP4:
Showing top 20/100 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RASGRP4 | PRG2 | 0.763788 | 3 | 0 | 3 |
| RASGRP4 | TMEM59L | 0.707929 | 3 | 0 | 3 |
| RASGRP4 | CACNG4 | 0.680793 | 4 | 0 | 4 |
| RASGRP4 | TRH | 0.667335 | 3 | 0 | 3 |
| RASGRP4 | KCNH3 | 0.667005 | 4 | 0 | 3 |
| RASGRP4 | EPB42 | 0.666046 | 4 | 0 | 3 |
| RASGRP4 | CLDN14 | 0.66125 | 4 | 0 | 3 |
| RASGRP4 | NUTM1 | 0.653344 | 3 | 0 | 3 |
| RASGRP4 | FBXL20 | 0.652214 | 3 | 0 | 3 |
| RASGRP4 | TUBA8 | 0.649766 | 4 | 0 | 3 |
| RASGRP4 | LINC00523 | 0.647399 | 3 | 0 | 3 |
| RASGRP4 | DPYSL4 | 0.644783 | 4 | 0 | 3 |
| RASGRP4 | CCL25 | 0.634056 | 4 | 0 | 4 |
| RASGRP4 | GRIK5 | 0.630874 | 4 | 0 | 3 |
| RASGRP4 | OPTC | 0.629476 | 5 | 0 | 3 |
| RASGRP4 | CYP17A1 | 0.628366 | 3 | 0 | 3 |
| RASGRP4 | RNF186 | 0.627064 | 3 | 0 | 3 |
| RASGRP4 | LIMD1-AS1 | 0.623523 | 4 | 0 | 3 |
| RASGRP4 | SMCP | 0.621682 | 5 | 0 | 4 |
| RASGRP4 | NRIP2 | 0.620331 | 3 | 0 | 3 |
For details and further investigation, click here
