| Full name: protein arginine methyltransferase 8 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12p13.32 | ||
| Entrez ID: 56341 | HGNC ID: HGNC:5188 | Ensembl Gene: ENSG00000111218 | OMIM ID: 610086 |
| Drug and gene relationship at DGIdb | |||
Expression of PRMT8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRMT8 | 56341 | 230839_at | 0.0883 | 0.8362 | |
| GSE20347 | PRMT8 | 56341 | 207772_s_at | 0.0658 | 0.3347 | |
| GSE23400 | PRMT8 | 56341 | 207772_s_at | -0.0772 | 0.0221 | |
| GSE26886 | PRMT8 | 56341 | 230839_at | 0.3268 | 0.0132 | |
| GSE29001 | PRMT8 | 56341 | 207772_s_at | -0.0680 | 0.4920 | |
| GSE38129 | PRMT8 | 56341 | 207772_s_at | -0.0064 | 0.9383 | |
| GSE45670 | PRMT8 | 56341 | 230839_at | 0.3223 | 0.0948 | |
| GSE53622 | PRMT8 | 56341 | 36422 | 0.5518 | 0.0005 | |
| GSE53624 | PRMT8 | 56341 | 36422 | 0.5071 | 0.0015 | |
| GSE63941 | PRMT8 | 56341 | 230839_at | -0.0223 | 0.9148 | |
| GSE77861 | PRMT8 | 56341 | 230839_at | 0.1292 | 0.3593 | |
| GSE97050 | PRMT8 | 56341 | A_23_P139740 | 0.0253 | 0.9445 | |
| TCGA | PRMT8 | 56341 | RNAseq | 0.9289 | 0.2783 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PRMT8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PRMT8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRMT8 | 56341 | 6 | 4 | 20 | |
| GSE20123 | PRMT8 | 56341 | 6 | 4 | 20 | |
| GSE43470 | PRMT8 | 56341 | 9 | 4 | 30 | |
| GSE46452 | PRMT8 | 56341 | 10 | 1 | 48 | |
| GSE47630 | PRMT8 | 56341 | 12 | 2 | 26 | |
| GSE54993 | PRMT8 | 56341 | 1 | 10 | 59 | |
| GSE54994 | PRMT8 | 56341 | 10 | 2 | 41 | |
| GSE60625 | PRMT8 | 56341 | 0 | 1 | 10 | |
| GSE74703 | PRMT8 | 56341 | 9 | 2 | 25 | |
| GSE74704 | PRMT8 | 56341 | 4 | 2 | 14 | |
| TCGA | PRMT8 | 56341 | 41 | 6 | 49 |
Total number of gains: 108; Total number of losses: 38; Total Number of normals: 342.
Somatic mutations of PRMT8:
Generating mutation plots.
Highly correlated genes for PRMT8:
Showing top 20/131 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRMT8 | ARHGDIG | 0.653128 | 3 | 0 | 3 |
| PRMT8 | PROX1 | 0.637315 | 3 | 0 | 3 |
| PRMT8 | CD320 | 0.631025 | 3 | 0 | 3 |
| PRMT8 | MAN1B1 | 0.630145 | 4 | 0 | 3 |
| PRMT8 | GAP43 | 0.62089 | 4 | 0 | 3 |
| PRMT8 | TRPM2 | 0.613524 | 4 | 0 | 3 |
| PRMT8 | KIAA0040 | 0.612355 | 3 | 0 | 3 |
| PRMT8 | CLDN15 | 0.611638 | 4 | 0 | 3 |
| PRMT8 | CA14 | 0.610587 | 5 | 0 | 4 |
| PRMT8 | MFGE8 | 0.610021 | 3 | 0 | 3 |
| PRMT8 | KIR2DL2 | 0.609331 | 4 | 0 | 3 |
| PRMT8 | CMTM3 | 0.603207 | 3 | 0 | 3 |
| PRMT8 | BMF | 0.599734 | 3 | 0 | 3 |
| PRMT8 | LFNG | 0.594959 | 4 | 0 | 4 |
| PRMT8 | KCNG1 | 0.587235 | 3 | 0 | 3 |
| PRMT8 | GDF9 | 0.586882 | 5 | 0 | 3 |
| PRMT8 | TMEM161A | 0.580874 | 4 | 0 | 3 |
| PRMT8 | ZNF335 | 0.579193 | 4 | 0 | 4 |
| PRMT8 | EFEMP2 | 0.578797 | 3 | 0 | 3 |
| PRMT8 | CCZ1 | 0.57827 | 4 | 0 | 3 |
For details and further investigation, click here
