| Full name: RAB6A, member RAS oncogene family | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 11q13.4 | ||
| Entrez ID: 5870 | HGNC ID: HGNC:9786 | Ensembl Gene: ENSG00000175582 | OMIM ID: 179513 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of RAB6A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RAB6A | 5870 | 1559174_at | -0.0920 | 0.7386 | |
| GSE26886 | RAB6A | 5870 | 1559174_at | -0.1028 | 0.4464 | |
| GSE45670 | RAB6A | 5870 | 1559174_at | 0.0284 | 0.8958 | |
| GSE53622 | RAB6A | 5870 | 4392 | -0.3615 | 0.0000 | |
| GSE53624 | RAB6A | 5870 | 4392 | -0.3716 | 0.0000 | |
| GSE63941 | RAB6A | 5870 | 1559174_at | -0.2617 | 0.0595 | |
| GSE77861 | RAB6A | 5870 | 1559174_at | -0.1380 | 0.2571 | |
| GSE97050 | RAB6A | 5870 | A_24_P13230 | 0.1060 | 0.7260 | |
| SRP007169 | RAB6A | 5870 | RNAseq | -0.8787 | 0.0627 | |
| SRP008496 | RAB6A | 5870 | RNAseq | -0.5720 | 0.0541 | |
| SRP064894 | RAB6A | 5870 | RNAseq | -0.3476 | 0.0474 | |
| SRP133303 | RAB6A | 5870 | RNAseq | -0.1755 | 0.4854 | |
| SRP159526 | RAB6A | 5870 | RNAseq | -0.8893 | 0.0041 | |
| SRP193095 | RAB6A | 5870 | RNAseq | -0.4244 | 0.0412 | |
| SRP219564 | RAB6A | 5870 | RNAseq | -0.3425 | 0.3903 | |
| TCGA | RAB6A | 5870 | RNAseq | 0.0749 | 0.1623 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by RAB6A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RAB6A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RAB6A | 5870 | 5 | 9 | 16 | |
| GSE20123 | RAB6A | 5870 | 5 | 8 | 17 | |
| GSE43470 | RAB6A | 5870 | 6 | 4 | 33 | |
| GSE46452 | RAB6A | 5870 | 9 | 20 | 30 | |
| GSE47630 | RAB6A | 5870 | 7 | 13 | 20 | |
| GSE54993 | RAB6A | 5870 | 8 | 2 | 60 | |
| GSE54994 | RAB6A | 5870 | 8 | 15 | 30 | |
| GSE60625 | RAB6A | 5870 | 0 | 7 | 4 | |
| GSE74703 | RAB6A | 5870 | 5 | 3 | 28 | |
| GSE74704 | RAB6A | 5870 | 3 | 4 | 13 | |
| TCGA | RAB6A | 5870 | 29 | 27 | 40 |
Total number of gains: 85; Total number of losses: 112; Total Number of normals: 291.
Somatic mutations of RAB6A:
Generating mutation plots.
Highly correlated genes for RAB6A:
Showing top 20/45 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RAB6A | HIVEP3 | 0.646373 | 3 | 0 | 3 |
| RAB6A | CIDEB | 0.644219 | 3 | 0 | 3 |
| RAB6A | NBEAL2 | 0.618701 | 4 | 0 | 3 |
| RAB6A | RIPK3 | 0.616185 | 3 | 0 | 3 |
| RAB6A | HUWE1 | 0.609147 | 3 | 0 | 3 |
| RAB6A | ADAM15 | 0.608599 | 3 | 0 | 3 |
| RAB6A | RAF1 | 0.605547 | 3 | 0 | 3 |
| RAB6A | UBXN8 | 0.597979 | 3 | 0 | 3 |
| RAB6A | TMEM129 | 0.591907 | 3 | 0 | 3 |
| RAB6A | RGS14 | 0.590271 | 5 | 0 | 3 |
| RAB6A | SNORD8 | 0.588489 | 3 | 0 | 3 |
| RAB6A | CCDC12 | 0.576882 | 6 | 0 | 4 |
| RAB6A | UBXN4 | 0.572554 | 3 | 0 | 3 |
| RAB6A | PLEKHN1 | 0.571871 | 4 | 0 | 3 |
| RAB6A | RER1 | 0.568817 | 4 | 0 | 3 |
| RAB6A | P2RY2 | 0.565574 | 7 | 0 | 4 |
| RAB6A | RNPEPL1 | 0.564763 | 4 | 0 | 3 |
| RAB6A | STK24 | 0.557513 | 4 | 0 | 3 |
| RAB6A | TSC22D4 | 0.555565 | 3 | 0 | 3 |
| RAB6A | MIOS | 0.551884 | 4 | 0 | 3 |
For details and further investigation, click here
