| Full name: purinergic receptor P2Y2 | Alias Symbol: P2U | ||
| Type: protein-coding gene | Cytoband: 11q13.4 | ||
| Entrez ID: 5029 | HGNC ID: HGNC:8541 | Ensembl Gene: ENSG00000175591 | OMIM ID: 600041 |
| Drug and gene relationship at DGIdb | |||
P2RY2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04750 | Inflammatory mediator regulation of TRP channels |
Expression of P2RY2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | P2RY2 | 5029 | 206277_at | -0.7107 | 0.5556 | |
| GSE20347 | P2RY2 | 5029 | 206277_at | -0.9954 | 0.0000 | |
| GSE23400 | P2RY2 | 5029 | 206277_at | -0.5066 | 0.0000 | |
| GSE26886 | P2RY2 | 5029 | 206277_at | -1.8926 | 0.0000 | |
| GSE29001 | P2RY2 | 5029 | 206277_at | -1.1133 | 0.0011 | |
| GSE38129 | P2RY2 | 5029 | 206277_at | -0.6135 | 0.0413 | |
| GSE45670 | P2RY2 | 5029 | 206277_at | -0.0455 | 0.9078 | |
| GSE53622 | P2RY2 | 5029 | 169542 | -1.1780 | 0.0000 | |
| GSE53624 | P2RY2 | 5029 | 169542 | -1.2097 | 0.0000 | |
| GSE63941 | P2RY2 | 5029 | 206277_at | 1.1486 | 0.1464 | |
| GSE77861 | P2RY2 | 5029 | 206277_at | -0.5394 | 0.1296 | |
| GSE97050 | P2RY2 | 5029 | A_23_P24903 | 0.0681 | 0.9503 | |
| SRP007169 | P2RY2 | 5029 | RNAseq | -2.4267 | 0.0000 | |
| SRP008496 | P2RY2 | 5029 | RNAseq | -2.0899 | 0.0000 | |
| SRP064894 | P2RY2 | 5029 | RNAseq | -1.6687 | 0.0000 | |
| SRP133303 | P2RY2 | 5029 | RNAseq | -0.8555 | 0.0327 | |
| SRP159526 | P2RY2 | 5029 | RNAseq | -3.2221 | 0.0000 | |
| SRP193095 | P2RY2 | 5029 | RNAseq | -1.0706 | 0.0004 | |
| SRP219564 | P2RY2 | 5029 | RNAseq | -1.9356 | 0.0520 | |
| TCGA | P2RY2 | 5029 | RNAseq | 0.4652 | 0.0166 |
Upregulated datasets: 0; Downregulated datasets: 9.
Survival by P2RY2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of P2RY2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | P2RY2 | 5029 | 8 | 7 | 15 | |
| GSE20123 | P2RY2 | 5029 | 8 | 7 | 15 | |
| GSE43470 | P2RY2 | 5029 | 9 | 2 | 32 | |
| GSE46452 | P2RY2 | 5029 | 10 | 19 | 30 | |
| GSE47630 | P2RY2 | 5029 | 7 | 13 | 20 | |
| GSE54993 | P2RY2 | 5029 | 8 | 2 | 60 | |
| GSE54994 | P2RY2 | 5029 | 8 | 15 | 30 | |
| GSE60625 | P2RY2 | 5029 | 0 | 7 | 4 | |
| GSE74703 | P2RY2 | 5029 | 7 | 2 | 27 | |
| GSE74704 | P2RY2 | 5029 | 6 | 3 | 11 | |
| TCGA | P2RY2 | 5029 | 28 | 27 | 41 |
Total number of gains: 99; Total number of losses: 104; Total Number of normals: 285.
Somatic mutations of P2RY2:
Generating mutation plots.
Highly correlated genes for P2RY2:
Showing top 20/1202 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| P2RY2 | EPGN | 0.741264 | 3 | 0 | 3 |
| P2RY2 | DSG3 | 0.728001 | 11 | 0 | 11 |
| P2RY2 | PRADC1 | 0.716613 | 4 | 0 | 3 |
| P2RY2 | EPHA1 | 0.716284 | 11 | 0 | 9 |
| P2RY2 | OSTF1 | 0.714945 | 10 | 0 | 10 |
| P2RY2 | ELOVL1 | 0.714273 | 3 | 0 | 3 |
| P2RY2 | ARAP2 | 0.711122 | 3 | 0 | 3 |
| P2RY2 | MIOS | 0.7082 | 11 | 0 | 10 |
| P2RY2 | AKTIP | 0.703065 | 4 | 0 | 4 |
| P2RY2 | PLD1 | 0.70221 | 10 | 0 | 10 |
| P2RY2 | PKP3 | 0.699421 | 12 | 0 | 11 |
| P2RY2 | HECTD1 | 0.69386 | 4 | 0 | 4 |
| P2RY2 | APOBEC1 | 0.69366 | 3 | 0 | 3 |
| P2RY2 | PROM2 | 0.691075 | 9 | 0 | 8 |
| P2RY2 | S100A14 | 0.691021 | 11 | 0 | 11 |
| P2RY2 | TMEM9B | 0.689969 | 10 | 0 | 8 |
| P2RY2 | ACSL3 | 0.687224 | 3 | 0 | 3 |
| P2RY2 | PGM2 | 0.685058 | 7 | 0 | 6 |
| P2RY2 | METRNL | 0.684364 | 4 | 0 | 4 |
| P2RY2 | CLDN7 | 0.683124 | 12 | 0 | 10 |
For details and further investigation, click here
