ARID1A

 

Full name: AT-rich interaction domain 1A Alias Symbol: B120|P270|C10rf4|BAF250|BAF250a
Type: protein-coding gene Cytoband: 1p36.11
Entrez ID: 8289 HGNC ID: HGNC:11110 Ensembl Gene: ENSG00000117713 OMIM ID: 603024
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 6/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of ARID1A:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ARID1A 8289 212152_x_at 0.4234 0.2858
GSE20347 ARID1A 8289 212152_x_at 0.0769 0.6237
GSE23400 ARID1A 8289 212152_x_at 0.1710 0.0001
GSE26886 ARID1A 8289 218917_s_at -0.1299 0.6398
GSE29001 ARID1A 8289 218917_s_at -0.0146 0.9617
GSE38129 ARID1A 8289 212152_x_at 0.0119 0.9416
GSE45670 ARID1A 8289 218917_s_at -0.0524 0.7329
GSE53622 ARID1A 8289 130287 0.1750 0.0065
GSE53624 ARID1A 8289 130287 0.1333 0.0890
GSE63941 ARID1A 8289 218917_s_at 0.7795 0.0067
GSE77861 ARID1A 8289 212152_x_at 0.0400 0.8976
GSE97050 ARID1A 8289 A_24_P92952 0.0640 0.8757
SRP007169 ARID1A 8289 RNAseq 1.4985 0.0005
SRP008496 ARID1A 8289 RNAseq 1.3029 0.0000
SRP064894 ARID1A 8289 RNAseq 0.0385 0.8347
SRP133303 ARID1A 8289 RNAseq 0.1001 0.4672
SRP159526 ARID1A 8289 RNAseq 0.0068 0.9772
SRP193095 ARID1A 8289 RNAseq 0.0436 0.6571
SRP219564 ARID1A 8289 RNAseq -0.3263 0.3227
TCGA ARID1A 8289 RNAseq -0.0296 0.4630

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by ARID1A expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ARID1A:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ARID1A 8289 0 6 24
GSE20123 ARID1A 8289 0 5 25
GSE43470 ARID1A 8289 2 6 35
GSE46452 ARID1A 8289 5 1 53
GSE47630 ARID1A 8289 8 3 29
GSE54993 ARID1A 8289 2 1 67
GSE54994 ARID1A 8289 10 4 39
GSE60625 ARID1A 8289 0 0 11
GSE74703 ARID1A 8289 1 4 31
GSE74704 ARID1A 8289 0 0 20
TCGA ARID1A 8289 9 25 62

Total number of gains: 37; Total number of losses: 55; Total Number of normals: 396.  

 

Somatic mutations of ARID1A:

 

Generating mutation plots.

 

Highly correlated genes for ARID1A:

 

Showing top 20/331 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ARID1ARAB7A0.79789303
ARID1AADCK10.781635303
ARID1ARPS190.758281303
ARID1ACHAMP10.757984303
ARID1ACCNT10.74038303
ARID1ARNF1390.73493303
ARID1AUFC10.725764303
ARID1ATRIM470.723177303
ARID1AARHGEF20.721067303
ARID1ADMTF10.718314303
ARID1ACDKN2C0.717619303
ARID1AMETTL80.715072303
ARID1ANDUFB40.713157404
ARID1AUBA520.708622303
ARID1AC12orf450.708004303
ARID1ARPS210.707392303
ARID1ACPLX10.705563303
ARID1APRDM150.703993403
ARID1AZNF3170.703903303
ARID1AABHD80.703015303

For details and further investigation, click here