| Full name: RAD1 checkpoint DNA exonuclease | Alias Symbol: HRAD1|REC1 | ||
| Type: protein-coding gene | Cytoband: 5p13.2 | ||
| Entrez ID: 5810 | HGNC ID: HGNC:9806 | Ensembl Gene: ENSG00000113456 | OMIM ID: 603153 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of RAD1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RAD1 | 5810 | 210216_x_at | 0.7689 | 0.0228 | |
| GSE20347 | RAD1 | 5810 | 204461_x_at | 0.7821 | 0.0000 | |
| GSE23400 | RAD1 | 5810 | 204461_x_at | 0.4293 | 0.0000 | |
| GSE26886 | RAD1 | 5810 | 204461_x_at | 0.6511 | 0.0009 | |
| GSE29001 | RAD1 | 5810 | 204461_x_at | 0.7445 | 0.0191 | |
| GSE38129 | RAD1 | 5810 | 204461_x_at | 0.6779 | 0.0001 | |
| GSE45670 | RAD1 | 5810 | 204461_x_at | 0.3892 | 0.0107 | |
| GSE53622 | RAD1 | 5810 | 7867 | 0.6579 | 0.0000 | |
| GSE53624 | RAD1 | 5810 | 99002 | 0.6556 | 0.0000 | |
| GSE63941 | RAD1 | 5810 | 210216_x_at | 0.2419 | 0.4240 | |
| GSE77861 | RAD1 | 5810 | 210216_x_at | 0.6367 | 0.0159 | |
| GSE97050 | RAD1 | 5810 | A_33_P3272828 | 0.3335 | 0.2181 | |
| SRP007169 | RAD1 | 5810 | RNAseq | 0.6227 | 0.1431 | |
| SRP008496 | RAD1 | 5810 | RNAseq | 0.7392 | 0.0151 | |
| SRP064894 | RAD1 | 5810 | RNAseq | 0.4046 | 0.0082 | |
| SRP133303 | RAD1 | 5810 | RNAseq | 0.6044 | 0.0002 | |
| SRP159526 | RAD1 | 5810 | RNAseq | 1.0126 | 0.0008 | |
| SRP193095 | RAD1 | 5810 | RNAseq | 0.3614 | 0.0002 | |
| SRP219564 | RAD1 | 5810 | RNAseq | 0.2056 | 0.2953 | |
| TCGA | RAD1 | 5810 | RNAseq | 0.1757 | 0.0018 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by RAD1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RAD1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RAD1 | 5810 | 10 | 0 | 20 | |
| GSE20123 | RAD1 | 5810 | 10 | 0 | 20 | |
| GSE43470 | RAD1 | 5810 | 18 | 0 | 25 | |
| GSE46452 | RAD1 | 5810 | 6 | 21 | 32 | |
| GSE47630 | RAD1 | 5810 | 6 | 12 | 22 | |
| GSE54993 | RAD1 | 5810 | 5 | 4 | 61 | |
| GSE54994 | RAD1 | 5810 | 26 | 2 | 25 | |
| GSE60625 | RAD1 | 5810 | 0 | 0 | 11 | |
| GSE74703 | RAD1 | 5810 | 14 | 0 | 22 | |
| GSE74704 | RAD1 | 5810 | 9 | 0 | 11 | |
| TCGA | RAD1 | 5810 | 52 | 6 | 38 |
Total number of gains: 156; Total number of losses: 45; Total Number of normals: 287.
Somatic mutations of RAD1:
Generating mutation plots.
Highly correlated genes for RAD1:
Showing top 20/1858 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RAD1 | UHMK1 | 0.813927 | 4 | 0 | 4 |
| RAD1 | CRTC2 | 0.793097 | 3 | 0 | 3 |
| RAD1 | WDR5 | 0.774619 | 4 | 0 | 4 |
| RAD1 | SPATA2 | 0.738725 | 5 | 0 | 5 |
| RAD1 | RRP36 | 0.738239 | 4 | 0 | 4 |
| RAD1 | RAD18 | 0.732419 | 3 | 0 | 3 |
| RAD1 | CDCA2 | 0.718543 | 5 | 0 | 5 |
| RAD1 | SLC15A4 | 0.71205 | 3 | 0 | 3 |
| RAD1 | BRIX1 | 0.710218 | 13 | 0 | 12 |
| RAD1 | CMTM4 | 0.709434 | 3 | 0 | 3 |
| RAD1 | SNAP47 | 0.706747 | 3 | 0 | 3 |
| RAD1 | MAZ | 0.705836 | 6 | 0 | 5 |
| RAD1 | DDX21 | 0.703966 | 5 | 0 | 4 |
| RAD1 | ARHGAP19 | 0.698141 | 4 | 0 | 4 |
| RAD1 | RACGAP1 | 0.697755 | 9 | 0 | 8 |
| RAD1 | MMS22L | 0.696442 | 3 | 0 | 3 |
| RAD1 | NUP155 | 0.693758 | 12 | 0 | 11 |
| RAD1 | TBCC | 0.693455 | 3 | 0 | 3 |
| RAD1 | FUS | 0.692801 | 9 | 0 | 9 |
| RAD1 | SSBP4 | 0.691052 | 4 | 0 | 3 |
For details and further investigation, click here
