| Full name: DExD-box helicase 21 | Alias Symbol: RH-II/GU|GURDB | ||
| Type: protein-coding gene | Cytoband: 10q22.1 | ||
| Entrez ID: 9188 | HGNC ID: HGNC:2744 | Ensembl Gene: ENSG00000165732 | OMIM ID: 606357 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of DDX21:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DDX21 | 9188 | 208152_s_at | 0.8240 | 0.0439 | |
| GSE20347 | DDX21 | 9188 | 208152_s_at | 0.4852 | 0.0133 | |
| GSE23400 | DDX21 | 9188 | 208152_s_at | 0.5641 | 0.0000 | |
| GSE26886 | DDX21 | 9188 | 208152_s_at | 0.4358 | 0.0185 | |
| GSE29001 | DDX21 | 9188 | 208152_s_at | 0.5054 | 0.0326 | |
| GSE38129 | DDX21 | 9188 | 208152_s_at | 0.7071 | 0.0000 | |
| GSE45670 | DDX21 | 9188 | 208152_s_at | 0.2907 | 0.1050 | |
| GSE53622 | DDX21 | 9188 | 71679 | 0.3335 | 0.0000 | |
| GSE53624 | DDX21 | 9188 | 71679 | 0.7702 | 0.0000 | |
| GSE63941 | DDX21 | 9188 | 208152_s_at | 0.3574 | 0.3889 | |
| GSE77861 | DDX21 | 9188 | 224654_at | 0.5680 | 0.1027 | |
| GSE97050 | DDX21 | 9188 | A_33_P3287815 | 0.6793 | 0.1368 | |
| SRP007169 | DDX21 | 9188 | RNAseq | 1.1357 | 0.0077 | |
| SRP008496 | DDX21 | 9188 | RNAseq | 1.1315 | 0.0000 | |
| SRP064894 | DDX21 | 9188 | RNAseq | -0.2178 | 0.4576 | |
| SRP133303 | DDX21 | 9188 | RNAseq | 0.9381 | 0.0001 | |
| SRP159526 | DDX21 | 9188 | RNAseq | 0.1069 | 0.8389 | |
| SRP193095 | DDX21 | 9188 | RNAseq | 0.4061 | 0.0016 | |
| SRP219564 | DDX21 | 9188 | RNAseq | -0.0769 | 0.8600 | |
| TCGA | DDX21 | 9188 | RNAseq | 0.1459 | 0.0035 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by DDX21 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DDX21:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DDX21 | 9188 | 3 | 4 | 23 | |
| GSE20123 | DDX21 | 9188 | 3 | 3 | 24 | |
| GSE43470 | DDX21 | 9188 | 1 | 8 | 34 | |
| GSE46452 | DDX21 | 9188 | 0 | 11 | 48 | |
| GSE47630 | DDX21 | 9188 | 2 | 14 | 24 | |
| GSE54993 | DDX21 | 9188 | 8 | 0 | 62 | |
| GSE54994 | DDX21 | 9188 | 2 | 12 | 39 | |
| GSE60625 | DDX21 | 9188 | 0 | 0 | 11 | |
| GSE74703 | DDX21 | 9188 | 1 | 5 | 30 | |
| GSE74704 | DDX21 | 9188 | 1 | 1 | 18 | |
| TCGA | DDX21 | 9188 | 10 | 22 | 64 |
Total number of gains: 31; Total number of losses: 80; Total Number of normals: 377.
Somatic mutations of DDX21:
Generating mutation plots.
Highly correlated genes for DDX21:
Showing top 20/1515 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DDX21 | ATP11C | 0.789293 | 3 | 0 | 3 |
| DDX21 | ZC3HC1 | 0.757207 | 3 | 0 | 3 |
| DDX21 | CMTM4 | 0.752965 | 3 | 0 | 3 |
| DDX21 | NOLC1 | 0.739312 | 12 | 0 | 12 |
| DDX21 | LRRC58 | 0.735193 | 5 | 0 | 4 |
| DDX21 | DOCK7 | 0.729809 | 4 | 0 | 3 |
| DDX21 | SND1 | 0.729018 | 3 | 0 | 3 |
| DDX21 | TTC30B | 0.724195 | 3 | 0 | 3 |
| DDX21 | KBTBD6 | 0.723701 | 3 | 0 | 3 |
| DDX21 | ENOPH1 | 0.715999 | 3 | 0 | 3 |
| DDX21 | TDRD5 | 0.713417 | 3 | 0 | 3 |
| DDX21 | ZSCAN29 | 0.710006 | 3 | 0 | 3 |
| DDX21 | SMCR8 | 0.707521 | 4 | 0 | 4 |
| DDX21 | CEP152 | 0.70696 | 3 | 0 | 3 |
| DDX21 | RPF2 | 0.705673 | 7 | 0 | 7 |
| DDX21 | CDCA2 | 0.705445 | 5 | 0 | 4 |
| DDX21 | RAD1 | 0.703966 | 5 | 0 | 4 |
| DDX21 | BORA | 0.703707 | 7 | 0 | 7 |
| DDX21 | WDR4 | 0.703368 | 4 | 0 | 3 |
| DDX21 | PRDX3 | 0.703347 | 4 | 0 | 4 |
For details and further investigation, click here
