| Full name: ADAM metallopeptidase with thrombospondin type 1 motif 1 | Alias Symbol: C3-C5|METH1|KIAA1346 | ||
| Type: protein-coding gene | Cytoband: 21q21.3 | ||
| Entrez ID: 9510 | HGNC ID: HGNC:217 | Ensembl Gene: ENSG00000154734 | OMIM ID: 605174 |
Expression of ADAMTS1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADAMTS1 | 9510 | 222162_s_at | -1.4843 | 0.0881 | |
| GSE20347 | ADAMTS1 | 9510 | 222162_s_at | -0.1104 | 0.7999 | |
| GSE23400 | ADAMTS1 | 9510 | 222162_s_at | -0.6179 | 0.0130 | |
| GSE26886 | ADAMTS1 | 9510 | 222162_s_at | 1.5161 | 0.0160 | |
| GSE29001 | ADAMTS1 | 9510 | 222162_s_at | -0.0825 | 0.9135 | |
| GSE38129 | ADAMTS1 | 9510 | 222162_s_at | -0.7162 | 0.0859 | |
| GSE45670 | ADAMTS1 | 9510 | 222162_s_at | -2.3556 | 0.0000 | |
| GSE53622 | ADAMTS1 | 9510 | 55085 | -1.4682 | 0.0000 | |
| GSE53624 | ADAMTS1 | 9510 | 55085 | -1.2237 | 0.0000 | |
| GSE63941 | ADAMTS1 | 9510 | 222162_s_at | -7.0141 | 0.0000 | |
| GSE77861 | ADAMTS1 | 9510 | 222162_s_at | 1.1407 | 0.0373 | |
| GSE97050 | ADAMTS1 | 9510 | A_23_P211039 | -0.3425 | 0.3704 | |
| SRP007169 | ADAMTS1 | 9510 | RNAseq | 2.4090 | 0.0004 | |
| SRP008496 | ADAMTS1 | 9510 | RNAseq | 2.5715 | 0.0000 | |
| SRP064894 | ADAMTS1 | 9510 | RNAseq | -0.9834 | 0.0269 | |
| SRP133303 | ADAMTS1 | 9510 | RNAseq | -0.7866 | 0.0414 | |
| SRP159526 | ADAMTS1 | 9510 | RNAseq | -0.8150 | 0.0392 | |
| SRP193095 | ADAMTS1 | 9510 | RNAseq | 1.3875 | 0.0001 | |
| SRP219564 | ADAMTS1 | 9510 | RNAseq | -0.5327 | 0.5480 | |
| TCGA | ADAMTS1 | 9510 | RNAseq | -0.6053 | 0.0000 |
Upregulated datasets: 5; Downregulated datasets: 4.
Survival by ADAMTS1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ADAMTS1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADAMTS1 | 9510 | 2 | 11 | 17 | |
| GSE20123 | ADAMTS1 | 9510 | 2 | 11 | 17 | |
| GSE43470 | ADAMTS1 | 9510 | 1 | 8 | 34 | |
| GSE46452 | ADAMTS1 | 9510 | 1 | 21 | 37 | |
| GSE47630 | ADAMTS1 | 9510 | 6 | 17 | 17 | |
| GSE54993 | ADAMTS1 | 9510 | 9 | 2 | 59 | |
| GSE54994 | ADAMTS1 | 9510 | 2 | 8 | 43 | |
| GSE60625 | ADAMTS1 | 9510 | 0 | 0 | 11 | |
| GSE74703 | ADAMTS1 | 9510 | 1 | 6 | 29 | |
| GSE74704 | ADAMTS1 | 9510 | 2 | 7 | 11 | |
| TCGA | ADAMTS1 | 9510 | 8 | 37 | 51 |
Total number of gains: 34; Total number of losses: 128; Total Number of normals: 326.
Somatic mutations of ADAMTS1:
Generating mutation plots.
Highly correlated genes for ADAMTS1:
Showing top 20/815 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADAMTS1 | C11orf96 | 0.78568 | 5 | 0 | 5 |
| ADAMTS1 | NEGR1 | 0.739769 | 6 | 0 | 6 |
| ADAMTS1 | SORCS1 | 0.732336 | 4 | 0 | 4 |
| ADAMTS1 | RASA3 | 0.727913 | 3 | 0 | 3 |
| ADAMTS1 | XKR4 | 0.713198 | 6 | 0 | 6 |
| ADAMTS1 | NEXN | 0.713055 | 8 | 0 | 8 |
| ADAMTS1 | ZNF583 | 0.713034 | 3 | 0 | 3 |
| ADAMTS1 | JAM2 | 0.711608 | 9 | 0 | 9 |
| ADAMTS1 | RSPO3 | 0.711558 | 7 | 0 | 7 |
| ADAMTS1 | BHMT2 | 0.709136 | 9 | 0 | 9 |
| ADAMTS1 | CYP21A2 | 0.708235 | 3 | 0 | 3 |
| ADAMTS1 | FHL5 | 0.706282 | 7 | 0 | 6 |
| ADAMTS1 | RCAN2 | 0.706278 | 11 | 0 | 11 |
| ADAMTS1 | APOLD1 | 0.706233 | 12 | 0 | 9 |
| ADAMTS1 | RSPO2 | 0.70597 | 3 | 0 | 3 |
| ADAMTS1 | MAGI2-AS3 | 0.705941 | 7 | 0 | 5 |
| ADAMTS1 | CADM2 | 0.705418 | 3 | 0 | 3 |
| ADAMTS1 | KCNT2 | 0.705234 | 6 | 0 | 6 |
| ADAMTS1 | APOD | 0.70518 | 8 | 0 | 8 |
| ADAMTS1 | CLEC3B | 0.704565 | 3 | 0 | 3 |
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