| Full name: synaptotagmin 8 | Alias Symbol: DKFZp434K0322 | ||
| Type: protein-coding gene | Cytoband: 11p15.5 | ||
| Entrez ID: 90019 | HGNC ID: HGNC:19264 | Ensembl Gene: ENSG00000149043 | OMIM ID: 607719 |
| Drug and gene relationship at DGIdb | |||
Expression of SYT8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SYT8 | 90019 | 232802_at | 0.2910 | 0.8460 | |
| GSE26886 | SYT8 | 90019 | 232802_at | 0.2965 | 0.4615 | |
| GSE45670 | SYT8 | 90019 | 232802_at | -0.5037 | 0.0030 | |
| GSE53622 | SYT8 | 90019 | 129876 | -1.2923 | 0.0000 | |
| GSE53624 | SYT8 | 90019 | 129876 | -1.9246 | 0.0000 | |
| GSE63941 | SYT8 | 90019 | 232802_at | 0.4758 | 0.2253 | |
| GSE77861 | SYT8 | 90019 | 232802_at | -0.6921 | 0.0025 | |
| GSE97050 | SYT8 | 90019 | A_33_P3364389 | 0.0879 | 0.7152 | |
| SRP007169 | SYT8 | 90019 | RNAseq | -4.9054 | 0.0000 | |
| SRP064894 | SYT8 | 90019 | RNAseq | -2.2420 | 0.0000 | |
| SRP133303 | SYT8 | 90019 | RNAseq | -2.3041 | 0.0000 | |
| SRP159526 | SYT8 | 90019 | RNAseq | -1.6710 | 0.0377 | |
| SRP193095 | SYT8 | 90019 | RNAseq | -1.6757 | 0.0001 | |
| SRP219564 | SYT8 | 90019 | RNAseq | -1.2286 | 0.3554 | |
| TCGA | SYT8 | 90019 | RNAseq | -0.0327 | 0.9346 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by SYT8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SYT8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SYT8 | 90019 | 1 | 11 | 18 | |
| GSE20123 | SYT8 | 90019 | 1 | 12 | 17 | |
| GSE43470 | SYT8 | 90019 | 1 | 9 | 33 | |
| GSE46452 | SYT8 | 90019 | 7 | 8 | 44 | |
| GSE47630 | SYT8 | 90019 | 4 | 12 | 24 | |
| GSE54993 | SYT8 | 90019 | 3 | 1 | 66 | |
| GSE54994 | SYT8 | 90019 | 1 | 12 | 40 | |
| GSE60625 | SYT8 | 90019 | 0 | 0 | 11 | |
| GSE74703 | SYT8 | 90019 | 1 | 7 | 28 | |
| GSE74704 | SYT8 | 90019 | 0 | 8 | 12 | |
| TCGA | SYT8 | 90019 | 8 | 39 | 49 |
Total number of gains: 27; Total number of losses: 119; Total Number of normals: 342.
Somatic mutations of SYT8:
Generating mutation plots.
Highly correlated genes for SYT8:
Showing top 20/454 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SYT8 | TNNI2 | 0.779009 | 7 | 0 | 6 |
| SYT8 | TP53I3 | 0.761752 | 4 | 0 | 4 |
| SYT8 | ASPG | 0.728563 | 4 | 0 | 4 |
| SYT8 | BNIPL | 0.724707 | 4 | 0 | 4 |
| SYT8 | FAM3D | 0.724453 | 4 | 0 | 4 |
| SYT8 | GALR3 | 0.724218 | 3 | 0 | 3 |
| SYT8 | HCG22 | 0.720353 | 4 | 0 | 4 |
| SYT8 | GMDS | 0.715247 | 4 | 0 | 4 |
| SYT8 | SH3GL1 | 0.713721 | 4 | 0 | 4 |
| SYT8 | GDPD3 | 0.713125 | 4 | 0 | 4 |
| SYT8 | MAPK3 | 0.709179 | 4 | 0 | 4 |
| SYT8 | SCNN1B | 0.707379 | 5 | 0 | 5 |
| SYT8 | RANBP9 | 0.703327 | 4 | 0 | 4 |
| SYT8 | TFAP2B | 0.701244 | 4 | 0 | 4 |
| SYT8 | PSCA | 0.701143 | 3 | 0 | 3 |
| SYT8 | DENND2D | 0.700751 | 4 | 0 | 4 |
| SYT8 | IL17RC | 0.700668 | 5 | 0 | 5 |
| SYT8 | RASGEF1A | 0.699843 | 3 | 0 | 3 |
| SYT8 | GYS2 | 0.699675 | 4 | 0 | 4 |
| SYT8 | EPS8L1 | 0.69927 | 5 | 0 | 5 |
For details and further investigation, click here
