| Full name: TNF receptor superfamily member 12A | Alias Symbol: FN14|TweakR|CD266 | ||
| Type: protein-coding gene | Cytoband: 16p13.3 | ||
| Entrez ID: 51330 | HGNC ID: HGNC:18152 | Ensembl Gene: ENSG00000006327 | OMIM ID: 605914 |
| Drug and gene relationship at DGIdb | |||
Expression of TNFRSF12A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TNFRSF12A | 51330 | 218368_s_at | 0.7940 | 0.1932 | |
| GSE20347 | TNFRSF12A | 51330 | 218368_s_at | 0.9278 | 0.0002 | |
| GSE23400 | TNFRSF12A | 51330 | 218368_s_at | 0.6575 | 0.0000 | |
| GSE26886 | TNFRSF12A | 51330 | 218368_s_at | 1.4025 | 0.0000 | |
| GSE29001 | TNFRSF12A | 51330 | 218368_s_at | 1.2751 | 0.0097 | |
| GSE38129 | TNFRSF12A | 51330 | 218368_s_at | 1.0734 | 0.0000 | |
| GSE45670 | TNFRSF12A | 51330 | 218368_s_at | 0.8439 | 0.0726 | |
| GSE53622 | TNFRSF12A | 51330 | 151282 | 2.1637 | 0.0000 | |
| GSE53624 | TNFRSF12A | 51330 | 151282 | 2.4972 | 0.0000 | |
| GSE63941 | TNFRSF12A | 51330 | 218368_s_at | -1.0018 | 0.1623 | |
| GSE77861 | TNFRSF12A | 51330 | 218368_s_at | 1.1021 | 0.0127 | |
| GSE97050 | TNFRSF12A | 51330 | A_23_P49338 | 1.5712 | 0.1480 | |
| SRP007169 | TNFRSF12A | 51330 | RNAseq | 2.9435 | 0.0000 | |
| SRP008496 | TNFRSF12A | 51330 | RNAseq | 3.5573 | 0.0000 | |
| SRP064894 | TNFRSF12A | 51330 | RNAseq | 1.8666 | 0.0000 | |
| SRP133303 | TNFRSF12A | 51330 | RNAseq | 3.0865 | 0.0000 | |
| SRP159526 | TNFRSF12A | 51330 | RNAseq | 1.2693 | 0.1433 | |
| SRP193095 | TNFRSF12A | 51330 | RNAseq | 2.4381 | 0.0000 | |
| SRP219564 | TNFRSF12A | 51330 | RNAseq | 1.0345 | 0.1372 | |
| TCGA | TNFRSF12A | 51330 | RNAseq | 0.2855 | 0.0144 |
Upregulated datasets: 11; Downregulated datasets: 0.
Survival by TNFRSF12A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TNFRSF12A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TNFRSF12A | 51330 | 5 | 5 | 20 | |
| GSE20123 | TNFRSF12A | 51330 | 5 | 4 | 21 | |
| GSE43470 | TNFRSF12A | 51330 | 3 | 8 | 32 | |
| GSE46452 | TNFRSF12A | 51330 | 38 | 1 | 20 | |
| GSE47630 | TNFRSF12A | 51330 | 13 | 6 | 21 | |
| GSE54993 | TNFRSF12A | 51330 | 3 | 5 | 62 | |
| GSE54994 | TNFRSF12A | 51330 | 5 | 9 | 39 | |
| GSE60625 | TNFRSF12A | 51330 | 4 | 0 | 7 | |
| GSE74703 | TNFRSF12A | 51330 | 3 | 6 | 27 | |
| GSE74704 | TNFRSF12A | 51330 | 3 | 2 | 15 | |
| TCGA | TNFRSF12A | 51330 | 19 | 13 | 64 |
Total number of gains: 101; Total number of losses: 59; Total Number of normals: 328.
Somatic mutations of TNFRSF12A:
Generating mutation plots.
Highly correlated genes for TNFRSF12A:
Showing top 20/1335 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TNFRSF12A | NGF | 0.763633 | 3 | 0 | 3 |
| TNFRSF12A | ZNF114 | 0.759446 | 4 | 0 | 4 |
| TNFRSF12A | SERPINE1 | 0.755775 | 13 | 0 | 13 |
| TNFRSF12A | FBLIM1 | 0.754771 | 7 | 0 | 7 |
| TNFRSF12A | LAMC2 | 0.752752 | 12 | 0 | 12 |
| TNFRSF12A | INHBA | 0.752156 | 12 | 0 | 12 |
| TNFRSF12A | CEBPB | 0.74818 | 11 | 0 | 11 |
| TNFRSF12A | MAD2L2 | 0.738441 | 4 | 0 | 4 |
| TNFRSF12A | MRGBP | 0.730428 | 10 | 0 | 10 |
| TNFRSF12A | PLAUR | 0.730299 | 13 | 0 | 12 |
| TNFRSF12A | XPR1 | 0.727976 | 7 | 0 | 7 |
| TNFRSF12A | HOMER3 | 0.723081 | 11 | 0 | 11 |
| TNFRSF12A | WDR54 | 0.721976 | 7 | 0 | 7 |
| TNFRSF12A | FSCN1 | 0.721255 | 12 | 0 | 12 |
| TNFRSF12A | NNMT | 0.721166 | 3 | 0 | 3 |
| TNFRSF12A | STC2 | 0.720249 | 10 | 0 | 10 |
| TNFRSF12A | PTHLH | 0.718967 | 12 | 0 | 12 |
| TNFRSF12A | LOXL2 | 0.718631 | 12 | 0 | 12 |
| TNFRSF12A | UCN2 | 0.716413 | 3 | 0 | 3 |
| TNFRSF12A | NTMT1 | 0.71523 | 7 | 0 | 7 |
For details and further investigation, click here
