CDC25B

 

Full name: cell division cycle 25B Alias Symbol: 
Type: protein-coding gene Cytoband: 20p13
Entrez ID: 994 HGNC ID: HGNC:1726 Ensembl Gene: ENSG00000101224 OMIM ID: 116949
Drug and gene relationship at DGIdb
Screen Evidence:

 

CDC25B involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04110Cell cycle
hsa04914Progesterone-mediated oocyte maturation

 

Expression of CDC25B:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CDC25B 994 201853_s_at 2.0322 0.0103
GSE20347 CDC25B 994 201853_s_at 1.5666 0.0000
GSE23400 CDC25B 994 201853_s_at 1.2998 0.0000
GSE26886 CDC25B 994 201853_s_at 0.9776 0.0187
GSE29001 CDC25B 994 201853_s_at 1.4705 0.0005
GSE38129 CDC25B 994 201853_s_at 1.4280 0.0000
GSE45670 CDC25B 994 201853_s_at 1.5507 0.0000
GSE53622 CDC25B 994 21402 1.8462 0.0000
GSE53624 CDC25B 994 21402 2.1450 0.0000
GSE63941 CDC25B 994 201853_s_at 0.2890 0.6880
GSE77861 CDC25B 994 201853_s_at 1.4710 0.0013
GSE97050 CDC25B 994 A_23_P210726 1.1058 0.1927
SRP007169 CDC25B 994 RNAseq 2.3193 0.0000
SRP008496 CDC25B 994 RNAseq 1.8364 0.0000
SRP064894 CDC25B 994 RNAseq 1.8594 0.0000
SRP133303 CDC25B 994 RNAseq 1.5711 0.0000
SRP159526 CDC25B 994 RNAseq 2.1347 0.0000
SRP193095 CDC25B 994 RNAseq 2.0207 0.0000
SRP219564 CDC25B 994 RNAseq 1.2832 0.0004
TCGA CDC25B 994 RNAseq 0.6642 0.0000

Upregulated datasets: 16; Downregulated datasets: 0.  

 

Survival by CDC25B expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CDC25B:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CDC25B 994 12 3 15
GSE20123 CDC25B 994 13 3 14
GSE43470 CDC25B 994 10 1 32
GSE46452 CDC25B 994 26 1 32
GSE47630 CDC25B 994 18 4 18
GSE54993 CDC25B 994 2 14 54
GSE54994 CDC25B 994 22 3 28
GSE60625 CDC25B 994 0 0 11
GSE74703 CDC25B 994 9 1 26
GSE74704 CDC25B 994 8 1 11
TCGA CDC25B 994 39 11 46

Total number of gains: 159; Total number of losses: 42; Total Number of normals: 287.  

 

Somatic mutations of CDC25B:

 

Generating mutation plots.

 

Highly correlated genes for CDC25B:

 

Showing top 20/1989 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CDC25BCD2760.815969404
CDC25BUBE2C0.81148211011
CDC25BUBE2T0.799965707
CDC25BAURKA0.79932611011
CDC25BLPCAT10.78569811010
CDC25BGINS10.78318511011
CDC25BTTL0.781221606
CDC25BKIF4A0.7803410010
CDC25BCKS1B0.77974811011
CDC25BARPC1B0.77747611011
CDC25BAPMAP0.7770310010
CDC25BMYBL20.77504811011
CDC25BSERPINH10.77464310010
CDC25BTPX20.77437711011
CDC25BUHRF10.774008707
CDC25BWDR660.770843707
CDC25BCOLGALT10.76815810010
CDC25BCDCA50.766497706
CDC25BFMNL20.766469707
CDC25BCHRNA10.761966303

For details and further investigation, click here