CCNA2

 

Full name: cyclin A2 Alias Symbol: 
Type: protein-coding gene Cytoband: 4q27
Entrez ID: 890 HGNC ID: HGNC:1578 Ensembl Gene: ENSG00000145386 OMIM ID: 123835
Drug and gene relationship at DGIdb
Screen Evidence:

 

CCNA2 involved pathways:

KEGG pathway Description View
hsa04110Cell cycle
hsa04152AMPK signaling pathway
hsa05169Epstein-Barr virus infection

 

Expression of CCNA2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CCNA2 890 213226_at 1.1938 0.0460
GSE20347 CCNA2 890 213226_at 0.8305 0.0000
GSE23400 CCNA2 890 213226_at 0.7757 0.0000
GSE26886 CCNA2 890 213226_at 0.4513 0.2595
GSE29001 CCNA2 890 213226_at 0.8434 0.0112
GSE38129 CCNA2 890 213226_at 1.2394 0.0000
GSE45670 CCNA2 890 213226_at 0.9411 0.0000
GSE53622 CCNA2 890 4225 1.6114 0.0000
GSE53624 CCNA2 890 4225 1.6653 0.0000
GSE63941 CCNA2 890 213226_at 1.5188 0.0084
GSE77861 CCNA2 890 213226_at 0.6799 0.1117
GSE97050 CCNA2 890 A_23_P58321 2.0287 0.1496
SRP007169 CCNA2 890 RNAseq 1.4038 0.0093
SRP008496 CCNA2 890 RNAseq 0.6827 0.0638
SRP064894 CCNA2 890 RNAseq 0.9157 0.0018
SRP133303 CCNA2 890 RNAseq 1.4581 0.0000
SRP159526 CCNA2 890 RNAseq 0.6057 0.0709
SRP193095 CCNA2 890 RNAseq 0.6677 0.0005
SRP219564 CCNA2 890 RNAseq 0.8005 0.2097
TCGA CCNA2 890 RNAseq 0.9707 0.0000

Upregulated datasets: 7; Downregulated datasets: 0.  

 

Survival by CCNA2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CCNA2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CCNA2 890 1 13 16
GSE20123 CCNA2 890 1 13 16
GSE43470 CCNA2 890 0 13 30
GSE46452 CCNA2 890 1 36 22
GSE47630 CCNA2 890 0 22 18
GSE54993 CCNA2 890 9 0 61
GSE54994 CCNA2 890 1 10 42
GSE60625 CCNA2 890 0 1 10
GSE74703 CCNA2 890 0 11 25
GSE74704 CCNA2 890 0 7 13
TCGA CCNA2 890 8 34 54

Total number of gains: 21; Total number of losses: 160; Total Number of normals: 307.  

 

Somatic mutations of CCNA2:

 

Generating mutation plots.

 

Highly correlated genes for CCNA2:

 

Showing top 20/1625 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CCNA2CDK10.85581712012
CCNA2TTK0.85363912012
CCNA2MAD2L10.83340113012
CCNA2CENPF0.81895812012
CCNA2CENPE0.81730113013
CCNA2NEK20.81669313012
CCNA2CEP550.81590813013
CCNA2ASPM0.81584713012
CCNA2TOP2A0.81582913013
CCNA2KPNA20.81226310010
CCNA2RACGAP10.80791311011
CCNA2MKI670.80771812012
CCNA2BUB10.80448611011
CCNA2KIF140.80411213012
CCNA2STIL0.80276312012
CCNA2KIF2C0.79981712012
CCNA2RAD51AP10.79935513013
CCNA2EME10.798959505
CCNA2KIF20A0.79882813012
CCNA2NUF20.798671908

For details and further investigation, click here