| Full name: ring finger and FYVE like domain containing E3 ubiquitin protein ligase | Alias Symbol: rififylin|fring|RNF189|RNF34L|CARP2|CARP-2 | ||
| Type: protein-coding gene | Cytoband: 17q12 | ||
| Entrez ID: 117584 | HGNC ID: HGNC:24821 | Ensembl Gene: ENSG00000092871 | OMIM ID: 609735 |
| Drug and gene relationship at DGIdb | |||
Expression of RFFL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RFFL | 117584 | 237919_at | -0.0100 | 0.9779 | |
| GSE26886 | RFFL | 117584 | 237919_at | -1.0430 | 0.0014 | |
| GSE45670 | RFFL | 117584 | 237919_at | -0.0829 | 0.6230 | |
| GSE63941 | RFFL | 117584 | 237919_at | 0.3385 | 0.3892 | |
| GSE77861 | RFFL | 117584 | 1566171_at | -0.1197 | 0.3944 | |
| GSE97050 | RFFL | 117584 | A_23_P164089 | -0.3145 | 0.2628 | |
| SRP007169 | RFFL | 117584 | RNAseq | -1.9704 | 0.0000 | |
| SRP008496 | RFFL | 117584 | RNAseq | -1.9048 | 0.0000 | |
| SRP064894 | RFFL | 117584 | RNAseq | -1.6021 | 0.0000 | |
| SRP133303 | RFFL | 117584 | RNAseq | -0.9657 | 0.0000 | |
| SRP159526 | RFFL | 117584 | RNAseq | -1.0802 | 0.0161 | |
| SRP193095 | RFFL | 117584 | RNAseq | -0.6215 | 0.0000 | |
| SRP219564 | RFFL | 117584 | RNAseq | -1.1295 | 0.0667 | |
| TCGA | RFFL | 117584 | RNAseq | 0.0323 | 0.6020 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by RFFL expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of RFFL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RFFL | 117584 | 5 | 1 | 24 | |
| GSE20123 | RFFL | 117584 | 5 | 1 | 24 | |
| GSE43470 | RFFL | 117584 | 1 | 2 | 40 | |
| GSE46452 | RFFL | 117584 | 34 | 0 | 25 | |
| GSE47630 | RFFL | 117584 | 7 | 1 | 32 | |
| GSE54993 | RFFL | 117584 | 3 | 3 | 64 | |
| GSE54994 | RFFL | 117584 | 8 | 6 | 39 | |
| GSE60625 | RFFL | 117584 | 4 | 0 | 7 | |
| GSE74703 | RFFL | 117584 | 1 | 1 | 34 | |
| GSE74704 | RFFL | 117584 | 3 | 1 | 16 | |
| TCGA | RFFL | 117584 | 20 | 9 | 67 |
Total number of gains: 91; Total number of losses: 25; Total Number of normals: 372.
Somatic mutations of RFFL:
Generating mutation plots.
Highly correlated genes for RFFL:
Showing top 20/116 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RFFL | ACAA1 | 0.766485 | 3 | 0 | 3 |
| RFFL | HDHD2 | 0.728053 | 3 | 0 | 3 |
| RFFL | OSBPL2 | 0.722349 | 3 | 0 | 3 |
| RFFL | KRT37 | 0.7204 | 3 | 0 | 3 |
| RFFL | RAB3D | 0.719859 | 3 | 0 | 3 |
| RFFL | COBLL1 | 0.718961 | 3 | 0 | 3 |
| RFFL | MFSD6 | 0.713156 | 4 | 0 | 3 |
| RFFL | MAP3K1 | 0.710573 | 3 | 0 | 3 |
| RFFL | ZNF506 | 0.707406 | 3 | 0 | 3 |
| RFFL | EIF2B4 | 0.698873 | 3 | 0 | 3 |
| RFFL | PSG5 | 0.69516 | 3 | 0 | 3 |
| RFFL | ZNF829 | 0.689917 | 3 | 0 | 3 |
| RFFL | SMURF1 | 0.688089 | 3 | 0 | 3 |
| RFFL | DALRD3 | 0.687923 | 3 | 0 | 3 |
| RFFL | CNOT10 | 0.686296 | 3 | 0 | 3 |
| RFFL | ITPKC | 0.683676 | 3 | 0 | 3 |
| RFFL | HSD17B4 | 0.679926 | 3 | 0 | 3 |
| RFFL | PPP1R3D | 0.678994 | 3 | 0 | 3 |
| RFFL | FAM166A | 0.67619 | 3 | 0 | 3 |
| RFFL | CHCHD10 | 0.675815 | 3 | 0 | 3 |
For details and further investigation, click here
