| Full name: SMAD family member 7 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 18q21.1 | ||
| Entrez ID: 4092 | HGNC ID: HGNC:6773 | Ensembl Gene: ENSG00000101665 | OMIM ID: 602932 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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SMAD7 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04350 | TGF-beta signaling pathway | |
| hsa04390 | Hippo signaling pathway |
Expression of SMAD7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SMAD7 | 4092 | 204790_at | 0.0719 | 0.9284 | |
| GSE20347 | SMAD7 | 4092 | 204790_at | 0.3905 | 0.0831 | |
| GSE23400 | SMAD7 | 4092 | 204790_at | 0.3791 | 0.0000 | |
| GSE26886 | SMAD7 | 4092 | 204790_at | 0.3853 | 0.2940 | |
| GSE29001 | SMAD7 | 4092 | 204790_at | 0.3070 | 0.4498 | |
| GSE38129 | SMAD7 | 4092 | 204790_at | 0.1738 | 0.4914 | |
| GSE45670 | SMAD7 | 4092 | 204790_at | -0.2660 | 0.3256 | |
| GSE53622 | SMAD7 | 4092 | 28860 | 0.4925 | 0.0000 | |
| GSE53624 | SMAD7 | 4092 | 28860 | 0.3618 | 0.0012 | |
| GSE63941 | SMAD7 | 4092 | 204790_at | -3.0401 | 0.0001 | |
| GSE77861 | SMAD7 | 4092 | 204790_at | 0.7619 | 0.0099 | |
| GSE97050 | SMAD7 | 4092 | A_23_P55518 | 0.0833 | 0.7674 | |
| SRP007169 | SMAD7 | 4092 | RNAseq | 0.7584 | 0.1331 | |
| SRP008496 | SMAD7 | 4092 | RNAseq | 1.8629 | 0.0002 | |
| SRP064894 | SMAD7 | 4092 | RNAseq | 0.5613 | 0.0210 | |
| SRP133303 | SMAD7 | 4092 | RNAseq | 0.4290 | 0.0763 | |
| SRP159526 | SMAD7 | 4092 | RNAseq | 0.2499 | 0.3925 | |
| SRP193095 | SMAD7 | 4092 | RNAseq | 0.2954 | 0.1946 | |
| SRP219564 | SMAD7 | 4092 | RNAseq | 0.2946 | 0.6071 | |
| TCGA | SMAD7 | 4092 | RNAseq | -0.2233 | 0.0014 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by SMAD7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SMAD7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SMAD7 | 4092 | 1 | 9 | 20 | |
| GSE20123 | SMAD7 | 4092 | 1 | 9 | 20 | |
| GSE43470 | SMAD7 | 4092 | 0 | 5 | 38 | |
| GSE46452 | SMAD7 | 4092 | 1 | 26 | 32 | |
| GSE47630 | SMAD7 | 4092 | 5 | 20 | 15 | |
| GSE54993 | SMAD7 | 4092 | 9 | 0 | 61 | |
| GSE54994 | SMAD7 | 4092 | 1 | 17 | 35 | |
| GSE60625 | SMAD7 | 4092 | 0 | 4 | 7 | |
| GSE74703 | SMAD7 | 4092 | 0 | 4 | 32 | |
| GSE74704 | SMAD7 | 4092 | 0 | 6 | 14 | |
| TCGA | SMAD7 | 4092 | 13 | 41 | 42 |
Total number of gains: 31; Total number of losses: 141; Total Number of normals: 316.
Somatic mutations of SMAD7:
Generating mutation plots.
Highly correlated genes for SMAD7:
Showing top 20/943 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SMAD7 | RGL1 | 0.729134 | 6 | 0 | 5 |
| SMAD7 | GPC6 | 0.707104 | 6 | 0 | 6 |
| SMAD7 | HSD11B1 | 0.695386 | 6 | 0 | 6 |
| SMAD7 | WTIP | 0.695152 | 7 | 0 | 6 |
| SMAD7 | SCYL1 | 0.694558 | 3 | 0 | 3 |
| SMAD7 | FAM20C | 0.693113 | 5 | 0 | 4 |
| SMAD7 | TMTC1 | 0.691268 | 4 | 0 | 3 |
| SMAD7 | MRFAP1 | 0.686739 | 3 | 0 | 3 |
| SMAD7 | LIN7A | 0.685221 | 4 | 0 | 4 |
| SMAD7 | DCHS1 | 0.682262 | 7 | 0 | 6 |
| SMAD7 | HERC2 | 0.681382 | 3 | 0 | 3 |
| SMAD7 | ITPKB | 0.677543 | 4 | 0 | 4 |
| SMAD7 | FBXO31 | 0.677052 | 4 | 0 | 3 |
| SMAD7 | TUBG2 | 0.67579 | 4 | 0 | 4 |
| SMAD7 | SGTB | 0.671442 | 5 | 0 | 4 |
| SMAD7 | SETD7 | 0.670046 | 3 | 0 | 3 |
| SMAD7 | LDB2 | 0.669611 | 4 | 0 | 4 |
| SMAD7 | TSPAN18 | 0.66888 | 3 | 0 | 3 |
| SMAD7 | ANGPT1 | 0.664584 | 5 | 0 | 5 |
| SMAD7 | CLMP | 0.664494 | 6 | 0 | 5 |
For details and further investigation, click here
