| Full name: maternal embryonic leucine zipper kinase | Alias Symbol: KIAA0175 | ||
| Type: protein-coding gene | Cytoband: 9p13.2 | ||
| Entrez ID: 9833 | HGNC ID: HGNC:16870 | Ensembl Gene: ENSG00000165304 | OMIM ID: 607025 |
| Drug and gene relationship at DGIdb | |||
Expression of MELK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MELK | 9833 | 204825_at | 1.1214 | 0.0799 | |
| GSE20347 | MELK | 9833 | 204825_at | 1.1953 | 0.0000 | |
| GSE23400 | MELK | 9833 | 204825_at | 1.3960 | 0.0000 | |
| GSE26886 | MELK | 9833 | 204825_at | -0.1642 | 0.6508 | |
| GSE29001 | MELK | 9833 | 204825_at | 1.4145 | 0.0002 | |
| GSE38129 | MELK | 9833 | 204825_at | 1.8101 | 0.0000 | |
| GSE45670 | MELK | 9833 | 204825_at | 1.3965 | 0.0000 | |
| GSE53622 | MELK | 9833 | 12116 | 1.4808 | 0.0000 | |
| GSE53624 | MELK | 9833 | 12116 | 1.8546 | 0.0000 | |
| GSE63941 | MELK | 9833 | 204825_at | 1.6099 | 0.0037 | |
| GSE77861 | MELK | 9833 | 204825_at | 0.5171 | 0.1634 | |
| GSE97050 | MELK | 9833 | A_23_P94422 | 1.3374 | 0.1628 | |
| SRP007169 | MELK | 9833 | RNAseq | 1.8450 | 0.0008 | |
| SRP008496 | MELK | 9833 | RNAseq | 2.5459 | 0.0000 | |
| SRP064894 | MELK | 9833 | RNAseq | 1.8174 | 0.0000 | |
| SRP133303 | MELK | 9833 | RNAseq | 1.4634 | 0.0000 | |
| SRP159526 | MELK | 9833 | RNAseq | 0.8571 | 0.0073 | |
| SRP193095 | MELK | 9833 | RNAseq | 1.0308 | 0.0000 | |
| SRP219564 | MELK | 9833 | RNAseq | 1.9931 | 0.0242 | |
| TCGA | MELK | 9833 | RNAseq | 1.2815 | 0.0000 |
Upregulated datasets: 15; Downregulated datasets: 0.
Survival by MELK expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MELK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MELK | 9833 | 3 | 11 | 16 | |
| GSE20123 | MELK | 9833 | 3 | 11 | 16 | |
| GSE43470 | MELK | 9833 | 1 | 12 | 30 | |
| GSE46452 | MELK | 9833 | 6 | 15 | 38 | |
| GSE47630 | MELK | 9833 | 1 | 20 | 19 | |
| GSE54993 | MELK | 9833 | 6 | 0 | 64 | |
| GSE54994 | MELK | 9833 | 5 | 12 | 36 | |
| GSE60625 | MELK | 9833 | 0 | 0 | 11 | |
| GSE74703 | MELK | 9833 | 1 | 8 | 27 | |
| GSE74704 | MELK | 9833 | 0 | 9 | 11 | |
| TCGA | MELK | 9833 | 14 | 45 | 37 |
Total number of gains: 40; Total number of losses: 143; Total Number of normals: 305.
Somatic mutations of MELK:
Generating mutation plots.
Highly correlated genes for MELK:
Showing top 20/1731 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MELK | CDC20 | 0.837784 | 11 | 0 | 11 |
| MELK | CEP55 | 0.832102 | 13 | 0 | 12 |
| MELK | BIRC5 | 0.822746 | 12 | 0 | 12 |
| MELK | CDK1 | 0.821052 | 12 | 0 | 12 |
| MELK | KIF2C | 0.819085 | 12 | 0 | 12 |
| MELK | DEPDC1B | 0.815521 | 7 | 0 | 7 |
| MELK | CCNB1 | 0.809629 | 12 | 0 | 12 |
| MELK | CDCA5 | 0.8085 | 7 | 0 | 7 |
| MELK | STIL | 0.807075 | 12 | 0 | 12 |
| MELK | DLGAP5 | 0.804663 | 13 | 0 | 13 |
| MELK | TPX2 | 0.804017 | 13 | 0 | 12 |
| MELK | CDC45 | 0.803493 | 11 | 0 | 11 |
| MELK | KIF4A | 0.799106 | 12 | 0 | 12 |
| MELK | CENPF | 0.797692 | 12 | 0 | 11 |
| MELK | HJURP | 0.796438 | 12 | 0 | 12 |
| MELK | PRC1 | 0.795346 | 13 | 0 | 13 |
| MELK | BUB1B | 0.794438 | 10 | 0 | 9 |
| MELK | KIF15 | 0.793886 | 12 | 0 | 12 |
| MELK | KNSTRN | 0.793675 | 6 | 0 | 6 |
| MELK | HMMR | 0.792401 | 12 | 0 | 12 |
For details and further investigation, click here
