| Full name: CCR4-NOT transcription complex subunit 8 | Alias Symbol: CAF1|hCAF1|CALIF | ||
| Type: protein-coding gene | Cytoband: 5q33.2 | ||
| Entrez ID: 9337 | HGNC ID: HGNC:9207 | Ensembl Gene: ENSG00000155508 | OMIM ID: 603731 |
| Drug and gene relationship at DGIdb | |||
Expression of CNOT8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CNOT8 | 9337 | 202164_s_at | -0.2447 | 0.7638 | |
| GSE20347 | CNOT8 | 9337 | 202163_s_at | 0.0864 | 0.5933 | |
| GSE23400 | CNOT8 | 9337 | 202164_s_at | 0.2885 | 0.0002 | |
| GSE26886 | CNOT8 | 9337 | 202163_s_at | 0.0527 | 0.8343 | |
| GSE29001 | CNOT8 | 9337 | 202163_s_at | 0.1513 | 0.7281 | |
| GSE38129 | CNOT8 | 9337 | 202163_s_at | 0.0537 | 0.6618 | |
| GSE45670 | CNOT8 | 9337 | 202163_s_at | -0.0148 | 0.9308 | |
| GSE53622 | CNOT8 | 9337 | 77392 | 0.1892 | 0.0014 | |
| GSE53624 | CNOT8 | 9337 | 77392 | 0.1293 | 0.2027 | |
| GSE63941 | CNOT8 | 9337 | 202164_s_at | 0.7117 | 0.0810 | |
| GSE77861 | CNOT8 | 9337 | 202162_s_at | 0.2244 | 0.4315 | |
| GSE97050 | CNOT8 | 9337 | A_23_P110846 | 0.3076 | 0.2429 | |
| SRP007169 | CNOT8 | 9337 | RNAseq | -0.3867 | 0.2119 | |
| SRP008496 | CNOT8 | 9337 | RNAseq | -0.5358 | 0.0101 | |
| SRP064894 | CNOT8 | 9337 | RNAseq | 0.0213 | 0.8028 | |
| SRP133303 | CNOT8 | 9337 | RNAseq | 0.1815 | 0.1813 | |
| SRP159526 | CNOT8 | 9337 | RNAseq | -0.0384 | 0.8969 | |
| SRP193095 | CNOT8 | 9337 | RNAseq | -0.0909 | 0.2226 | |
| SRP219564 | CNOT8 | 9337 | RNAseq | -0.0948 | 0.5245 | |
| TCGA | CNOT8 | 9337 | RNAseq | -0.0513 | 0.2848 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CNOT8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CNOT8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CNOT8 | 9337 | 0 | 12 | 18 | |
| GSE20123 | CNOT8 | 9337 | 0 | 12 | 18 | |
| GSE43470 | CNOT8 | 9337 | 2 | 10 | 31 | |
| GSE46452 | CNOT8 | 9337 | 0 | 27 | 32 | |
| GSE47630 | CNOT8 | 9337 | 0 | 20 | 20 | |
| GSE54993 | CNOT8 | 9337 | 9 | 1 | 60 | |
| GSE54994 | CNOT8 | 9337 | 1 | 16 | 36 | |
| GSE60625 | CNOT8 | 9337 | 0 | 0 | 11 | |
| GSE74703 | CNOT8 | 9337 | 2 | 8 | 26 | |
| GSE74704 | CNOT8 | 9337 | 0 | 7 | 13 | |
| TCGA | CNOT8 | 9337 | 4 | 38 | 54 |
Total number of gains: 18; Total number of losses: 151; Total Number of normals: 319.
Somatic mutations of CNOT8:
Generating mutation plots.
Highly correlated genes for CNOT8:
Showing top 20/111 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CNOT8 | EIF2S2 | 0.688086 | 4 | 0 | 4 |
| CNOT8 | RTCB | 0.68006 | 4 | 0 | 4 |
| CNOT8 | SNRPB | 0.63386 | 3 | 0 | 3 |
| CNOT8 | NRBF2 | 0.619503 | 3 | 0 | 3 |
| CNOT8 | ST13 | 0.612906 | 5 | 0 | 3 |
| CNOT8 | SNX2 | 0.604124 | 4 | 0 | 4 |
| CNOT8 | SMARCA5 | 0.595343 | 8 | 0 | 7 |
| CNOT8 | CDC23 | 0.594731 | 7 | 0 | 4 |
| CNOT8 | ZNF627 | 0.594626 | 4 | 0 | 4 |
| CNOT8 | CRYZ | 0.593441 | 4 | 0 | 3 |
| CNOT8 | SEC24B | 0.590832 | 4 | 0 | 3 |
| CNOT8 | SMU1 | 0.589096 | 4 | 0 | 3 |
| CNOT8 | MIS18BP1 | 0.587498 | 3 | 0 | 3 |
| CNOT8 | ATRAID | 0.584197 | 4 | 0 | 3 |
| CNOT8 | PSME1 | 0.579313 | 5 | 0 | 4 |
| CNOT8 | TTC4 | 0.575959 | 3 | 0 | 3 |
| CNOT8 | RWDD1 | 0.575735 | 3 | 0 | 3 |
| CNOT8 | IMPACT | 0.573214 | 4 | 0 | 3 |
| CNOT8 | CTDSPL2 | 0.572993 | 6 | 0 | 4 |
| CNOT8 | PIGH | 0.572172 | 3 | 0 | 3 |
For details and further investigation, click here
