| Full name: desmocollin 1 | Alias Symbol: CDHF1 | ||
| Type: protein-coding gene | Cytoband: 18q12.1 | ||
| Entrez ID: 1823 | HGNC ID: HGNC:3035 | Ensembl Gene: ENSG00000134765 | OMIM ID: 125643 |
| Drug and gene relationship at DGIdb | |||
Expression of DSC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DSC1 | 1823 | 207324_s_at | 0.3668 | 0.8203 | |
| GSE20347 | DSC1 | 1823 | 207324_s_at | 0.4001 | 0.3885 | |
| GSE23400 | DSC1 | 1823 | 207324_s_at | 0.0644 | 0.5932 | |
| GSE26886 | DSC1 | 1823 | 207324_s_at | 0.4633 | 0.4681 | |
| GSE29001 | DSC1 | 1823 | 207324_s_at | 0.5874 | 0.4643 | |
| GSE38129 | DSC1 | 1823 | 207324_s_at | 0.4067 | 0.2899 | |
| GSE45670 | DSC1 | 1823 | 207324_s_at | 1.3862 | 0.1289 | |
| GSE53622 | DSC1 | 1823 | 13106 | 0.6640 | 0.1747 | |
| GSE53624 | DSC1 | 1823 | 13106 | 0.4902 | 0.1225 | |
| GSE63941 | DSC1 | 1823 | 207324_s_at | 0.2821 | 0.1815 | |
| GSE77861 | DSC1 | 1823 | 207324_s_at | 1.3202 | 0.1383 | |
| GSE97050 | DSC1 | 1823 | A_23_P38696 | -0.8728 | 0.4438 | |
| SRP007169 | DSC1 | 1823 | RNAseq | 0.8608 | 0.1399 | |
| SRP133303 | DSC1 | 1823 | RNAseq | 0.6620 | 0.1600 | |
| TCGA | DSC1 | 1823 | RNAseq | 1.7443 | 0.0002 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by DSC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DSC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DSC1 | 1823 | 3 | 6 | 21 | |
| GSE20123 | DSC1 | 1823 | 3 | 6 | 21 | |
| GSE43470 | DSC1 | 1823 | 0 | 2 | 41 | |
| GSE46452 | DSC1 | 1823 | 1 | 25 | 33 | |
| GSE47630 | DSC1 | 1823 | 5 | 20 | 15 | |
| GSE54993 | DSC1 | 1823 | 7 | 1 | 62 | |
| GSE54994 | DSC1 | 1823 | 2 | 16 | 35 | |
| GSE60625 | DSC1 | 1823 | 0 | 4 | 7 | |
| GSE74703 | DSC1 | 1823 | 0 | 2 | 34 | |
| GSE74704 | DSC1 | 1823 | 1 | 5 | 14 | |
| TCGA | DSC1 | 1823 | 14 | 36 | 46 |
Total number of gains: 36; Total number of losses: 123; Total Number of normals: 329.
Somatic mutations of DSC1:
Generating mutation plots.
Highly correlated genes for DSC1:
Showing top 20/45 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DSC1 | RTCB | 0.689814 | 3 | 0 | 3 |
| DSC1 | ASPRV1 | 0.654003 | 7 | 0 | 7 |
| DSC1 | FAM192A | 0.647055 | 4 | 0 | 3 |
| DSC1 | MRPL28 | 0.638352 | 4 | 0 | 3 |
| DSC1 | SLC36A1 | 0.63786 | 3 | 0 | 3 |
| DSC1 | PRR9 | 0.615659 | 5 | 0 | 5 |
| DSC1 | SPRR2G | 0.597434 | 6 | 0 | 5 |
| DSC1 | RBM19 | 0.595725 | 4 | 0 | 3 |
| DSC1 | LRRC8E | 0.586452 | 4 | 0 | 3 |
| DSC1 | CALB1 | 0.581994 | 6 | 0 | 3 |
| DSC1 | MYH9 | 0.579071 | 4 | 0 | 3 |
| DSC1 | GJA3 | 0.576601 | 4 | 0 | 3 |
| DSC1 | WFDC5 | 0.570191 | 5 | 0 | 3 |
| DSC1 | IGFL2 | 0.567138 | 7 | 0 | 4 |
| DSC1 | CNTNAP2 | 0.564378 | 4 | 0 | 3 |
| DSC1 | KRTDAP | 0.559036 | 8 | 0 | 6 |
| DSC1 | CDSN | 0.555042 | 9 | 0 | 4 |
| DSC1 | SLC7A8 | 0.555005 | 7 | 0 | 6 |
| DSC1 | SERPINB7 | 0.553256 | 8 | 0 | 4 |
| DSC1 | ABCA12 | 0.55292 | 12 | 0 | 9 |
For details and further investigation, click here
