| Full name: plakophilin 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 11p15.5 | ||
| Entrez ID: 11187 | HGNC ID: HGNC:9025 | Ensembl Gene: ENSG00000184363 | OMIM ID: 605561 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PKP3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PKP3 | 11187 | 209873_s_at | -0.8380 | 0.3905 | |
| GSE20347 | PKP3 | 11187 | 209873_s_at | -1.7836 | 0.0000 | |
| GSE23400 | PKP3 | 11187 | 209873_s_at | -0.9372 | 0.0000 | |
| GSE26886 | PKP3 | 11187 | 209873_s_at | -0.9199 | 0.0022 | |
| GSE29001 | PKP3 | 11187 | 209873_s_at | -1.3617 | 0.0005 | |
| GSE38129 | PKP3 | 11187 | 209873_s_at | -0.8523 | 0.0547 | |
| GSE45670 | PKP3 | 11187 | 209873_s_at | -0.3991 | 0.1331 | |
| GSE53622 | PKP3 | 11187 | 92131 | -1.4838 | 0.0000 | |
| GSE53624 | PKP3 | 11187 | 92131 | -1.6187 | 0.0000 | |
| GSE63941 | PKP3 | 11187 | 209873_s_at | 2.6361 | 0.0001 | |
| GSE77861 | PKP3 | 11187 | 209873_s_at | -0.7648 | 0.0635 | |
| GSE97050 | PKP3 | 11187 | A_33_P3317628 | 0.1397 | 0.9439 | |
| SRP007169 | PKP3 | 11187 | RNAseq | -2.7638 | 0.0000 | |
| SRP008496 | PKP3 | 11187 | RNAseq | -2.4871 | 0.0000 | |
| SRP064894 | PKP3 | 11187 | RNAseq | -1.2349 | 0.0047 | |
| SRP133303 | PKP3 | 11187 | RNAseq | -1.7122 | 0.0000 | |
| SRP159526 | PKP3 | 11187 | RNAseq | -1.9348 | 0.0000 | |
| SRP193095 | PKP3 | 11187 | RNAseq | -1.4360 | 0.0000 | |
| SRP219564 | PKP3 | 11187 | RNAseq | -1.1366 | 0.3245 | |
| TCGA | PKP3 | 11187 | RNAseq | 0.4777 | 0.0009 |
Upregulated datasets: 1; Downregulated datasets: 10.
Survival by PKP3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PKP3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PKP3 | 11187 | 1 | 11 | 18 | |
| GSE20123 | PKP3 | 11187 | 1 | 12 | 17 | |
| GSE43470 | PKP3 | 11187 | 1 | 10 | 32 | |
| GSE46452 | PKP3 | 11187 | 7 | 8 | 44 | |
| GSE47630 | PKP3 | 11187 | 4 | 12 | 24 | |
| GSE54993 | PKP3 | 11187 | 3 | 2 | 65 | |
| GSE54994 | PKP3 | 11187 | 1 | 12 | 40 | |
| GSE60625 | PKP3 | 11187 | 0 | 0 | 11 | |
| GSE74703 | PKP3 | 11187 | 1 | 8 | 27 | |
| GSE74704 | PKP3 | 11187 | 0 | 8 | 12 | |
| TCGA | PKP3 | 11187 | 8 | 38 | 50 |
Total number of gains: 27; Total number of losses: 121; Total Number of normals: 340.
Somatic mutations of PKP3:
Generating mutation plots.
Highly correlated genes for PKP3:
Showing top 20/1291 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PKP3 | S100A14 | 0.832664 | 12 | 0 | 12 |
| PKP3 | EVPL | 0.827451 | 12 | 0 | 12 |
| PKP3 | S100A16 | 0.819032 | 8 | 0 | 8 |
| PKP3 | EPS8L2 | 0.809421 | 11 | 0 | 10 |
| PKP3 | TRIP10 | 0.789125 | 11 | 0 | 11 |
| PKP3 | SLC35C1 | 0.785112 | 10 | 0 | 10 |
| PKP3 | CLTB | 0.78479 | 10 | 0 | 10 |
| PKP3 | ALS2CL | 0.782163 | 11 | 0 | 11 |
| PKP3 | TRIM29 | 0.77892 | 12 | 0 | 12 |
| PKP3 | C19orf33 | 0.772016 | 8 | 0 | 8 |
| PKP3 | PTK6 | 0.771065 | 12 | 0 | 11 |
| PKP3 | NIPAL1 | 0.769882 | 3 | 0 | 3 |
| PKP3 | LAD1 | 0.769668 | 13 | 0 | 12 |
| PKP3 | GNA15 | 0.768815 | 13 | 0 | 12 |
| PKP3 | TMEM40 | 0.768672 | 13 | 0 | 13 |
| PKP3 | NBEAL2 | 0.765406 | 12 | 0 | 12 |
| PKP3 | DUOX1 | 0.76526 | 12 | 0 | 11 |
| PKP3 | RHOD | 0.761238 | 13 | 0 | 13 |
| PKP3 | IL1RN | 0.760084 | 12 | 0 | 12 |
| PKP3 | BNIPL | 0.759156 | 7 | 0 | 7 |
For details and further investigation, click here
