| Full name: secretogranin II | Alias Symbol: CHGC|SgII|SN | ||
| Type: protein-coding gene | Cytoband: 2q36.1 | ||
| Entrez ID: 7857 | HGNC ID: HGNC:10575 | Ensembl Gene: ENSG00000171951 | OMIM ID: 118930 |
| Drug and gene relationship at DGIdb | |||
Expression of SCG2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SCG2 | 7857 | 204035_at | -0.1336 | 0.9082 | |
| GSE20347 | SCG2 | 7857 | 204035_at | 0.2921 | 0.3312 | |
| GSE23400 | SCG2 | 7857 | 204035_at | 0.0600 | 0.3127 | |
| GSE26886 | SCG2 | 7857 | 204035_at | 1.4312 | 0.0071 | |
| GSE29001 | SCG2 | 7857 | 204035_at | 0.2163 | 0.3170 | |
| GSE38129 | SCG2 | 7857 | 204035_at | 0.3704 | 0.3817 | |
| GSE45670 | SCG2 | 7857 | 204035_at | 0.5543 | 0.1933 | |
| GSE53622 | SCG2 | 7857 | 38562 | 1.2700 | 0.0000 | |
| GSE53624 | SCG2 | 7857 | 38562 | 2.1959 | 0.0000 | |
| GSE63941 | SCG2 | 7857 | 204035_at | -3.1388 | 0.0158 | |
| GSE77861 | SCG2 | 7857 | 204035_at | 0.2739 | 0.3779 | |
| GSE97050 | SCG2 | 7857 | A_24_P88696 | 0.2758 | 0.5133 | |
| SRP064894 | SCG2 | 7857 | RNAseq | 4.5385 | 0.0000 | |
| SRP133303 | SCG2 | 7857 | RNAseq | 2.8046 | 0.0000 | |
| SRP159526 | SCG2 | 7857 | RNAseq | 4.6719 | 0.0000 | |
| SRP219564 | SCG2 | 7857 | RNAseq | 2.4894 | 0.0482 | |
| TCGA | SCG2 | 7857 | RNAseq | -1.0420 | 0.0008 |
Upregulated datasets: 7; Downregulated datasets: 2.
Survival by SCG2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SCG2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SCG2 | 7857 | 2 | 12 | 16 | |
| GSE20123 | SCG2 | 7857 | 2 | 12 | 16 | |
| GSE43470 | SCG2 | 7857 | 0 | 7 | 36 | |
| GSE46452 | SCG2 | 7857 | 0 | 5 | 54 | |
| GSE47630 | SCG2 | 7857 | 4 | 5 | 31 | |
| GSE54993 | SCG2 | 7857 | 1 | 2 | 67 | |
| GSE54994 | SCG2 | 7857 | 7 | 10 | 36 | |
| GSE60625 | SCG2 | 7857 | 3 | 0 | 8 | |
| GSE74703 | SCG2 | 7857 | 0 | 6 | 30 | |
| GSE74704 | SCG2 | 7857 | 2 | 6 | 12 | |
| TCGA | SCG2 | 7857 | 13 | 27 | 56 |
Total number of gains: 34; Total number of losses: 92; Total Number of normals: 362.
Somatic mutations of SCG2:
Generating mutation plots.
Highly correlated genes for SCG2:
Showing top 20/454 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SCG2 | ICAM2 | 0.713378 | 4 | 0 | 4 |
| SCG2 | FKBP7 | 0.697104 | 3 | 0 | 3 |
| SCG2 | PCSK1N | 0.69687 | 4 | 0 | 4 |
| SCG2 | RETN | 0.679725 | 3 | 0 | 3 |
| SCG2 | LOXL3 | 0.671414 | 4 | 0 | 4 |
| SCG2 | BMP5 | 0.658 | 3 | 0 | 3 |
| SCG2 | EGFLAM | 0.65164 | 4 | 0 | 3 |
| SCG2 | LRCH1 | 0.648322 | 3 | 0 | 3 |
| SCG2 | TMTC1 | 0.646221 | 3 | 0 | 3 |
| SCG2 | PEG10 | 0.642033 | 4 | 0 | 3 |
| SCG2 | CT83 | 0.639571 | 3 | 0 | 3 |
| SCG2 | ARL3 | 0.638495 | 4 | 0 | 3 |
| SCG2 | IL17D | 0.638123 | 3 | 0 | 3 |
| SCG2 | CCDC130 | 0.638025 | 3 | 0 | 3 |
| SCG2 | B4GALNT1 | 0.636039 | 7 | 0 | 7 |
| SCG2 | TTLL7 | 0.630751 | 3 | 0 | 3 |
| SCG2 | G0S2 | 0.630178 | 5 | 0 | 5 |
| SCG2 | PTPDC1 | 0.625332 | 5 | 0 | 4 |
| SCG2 | NME5 | 0.621979 | 3 | 0 | 3 |
| SCG2 | ANO6 | 0.621814 | 5 | 0 | 4 |
For details and further investigation, click here
