| Full name: nuclear factor, erythroid 2 like 1 | Alias Symbol: NRF1|LCR-F1|FLJ00380 | ||
| Type: protein-coding gene | Cytoband: 17q21.3 | ||
| Entrez ID: 4779 | HGNC ID: HGNC:7781 | Ensembl Gene: ENSG00000082641 | OMIM ID: 163260 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of NFE2L1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NFE2L1 | 4779 | 200759_x_at | 0.3754 | 0.4361 | |
| GSE20347 | NFE2L1 | 4779 | 200758_s_at | 0.7512 | 0.0000 | |
| GSE23400 | NFE2L1 | 4779 | 200759_x_at | 0.4518 | 0.0000 | |
| GSE26886 | NFE2L1 | 4779 | 200759_x_at | 1.2292 | 0.0000 | |
| GSE29001 | NFE2L1 | 4779 | 200759_x_at | 0.9808 | 0.0000 | |
| GSE38129 | NFE2L1 | 4779 | 200758_s_at | 0.6047 | 0.0001 | |
| GSE45670 | NFE2L1 | 4779 | 200759_x_at | 0.3972 | 0.0277 | |
| GSE53622 | NFE2L1 | 4779 | 21460 | 0.4258 | 0.0000 | |
| GSE53624 | NFE2L1 | 4779 | 44047 | 0.9826 | 0.0000 | |
| GSE63941 | NFE2L1 | 4779 | 200759_x_at | -0.4993 | 0.4056 | |
| GSE77861 | NFE2L1 | 4779 | 200759_x_at | 1.1263 | 0.0009 | |
| GSE97050 | NFE2L1 | 4779 | A_24_P219552 | -0.0454 | 0.8738 | |
| SRP007169 | NFE2L1 | 4779 | RNAseq | 2.1849 | 0.0000 | |
| SRP008496 | NFE2L1 | 4779 | RNAseq | 2.1724 | 0.0000 | |
| SRP064894 | NFE2L1 | 4779 | RNAseq | 0.8606 | 0.0000 | |
| SRP133303 | NFE2L1 | 4779 | RNAseq | 1.0472 | 0.0000 | |
| SRP159526 | NFE2L1 | 4779 | RNAseq | 0.7299 | 0.0000 | |
| SRP193095 | NFE2L1 | 4779 | RNAseq | 1.0280 | 0.0000 | |
| SRP219564 | NFE2L1 | 4779 | RNAseq | 0.4837 | 0.2667 | |
| TCGA | NFE2L1 | 4779 | RNAseq | 0.0560 | 0.2034 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by NFE2L1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NFE2L1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NFE2L1 | 4779 | 5 | 2 | 23 | |
| GSE20123 | NFE2L1 | 4779 | 5 | 2 | 23 | |
| GSE43470 | NFE2L1 | 4779 | 1 | 2 | 40 | |
| GSE46452 | NFE2L1 | 4779 | 32 | 0 | 27 | |
| GSE47630 | NFE2L1 | 4779 | 9 | 0 | 31 | |
| GSE54993 | NFE2L1 | 4779 | 2 | 4 | 64 | |
| GSE54994 | NFE2L1 | 4779 | 11 | 5 | 37 | |
| GSE60625 | NFE2L1 | 4779 | 4 | 0 | 7 | |
| GSE74703 | NFE2L1 | 4779 | 1 | 1 | 34 | |
| GSE74704 | NFE2L1 | 4779 | 4 | 1 | 15 | |
| TCGA | NFE2L1 | 4779 | 27 | 6 | 63 |
Total number of gains: 101; Total number of losses: 23; Total Number of normals: 364.
Somatic mutations of NFE2L1:
Generating mutation plots.
Highly correlated genes for NFE2L1:
Showing top 20/1896 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NFE2L1 | FAF2 | 0.835972 | 3 | 0 | 3 |
| NFE2L1 | AP3D1 | 0.793501 | 3 | 0 | 3 |
| NFE2L1 | LPCAT1 | 0.771541 | 11 | 0 | 11 |
| NFE2L1 | SDHAF2 | 0.759536 | 3 | 0 | 3 |
| NFE2L1 | FADS1 | 0.755575 | 3 | 0 | 3 |
| NFE2L1 | ALKBH6 | 0.750548 | 4 | 0 | 3 |
| NFE2L1 | SMARCE1 | 0.750232 | 4 | 0 | 4 |
| NFE2L1 | ENAH | 0.74464 | 11 | 0 | 11 |
| NFE2L1 | FNDC3B | 0.744074 | 11 | 0 | 11 |
| NFE2L1 | C1orf216 | 0.732156 | 11 | 0 | 9 |
| NFE2L1 | POLRMT | 0.728904 | 3 | 0 | 3 |
| NFE2L1 | GNA12 | 0.726997 | 11 | 0 | 11 |
| NFE2L1 | PLOD1 | 0.724544 | 11 | 0 | 11 |
| NFE2L1 | FXR1 | 0.720181 | 9 | 0 | 9 |
| NFE2L1 | MMD | 0.71961 | 11 | 0 | 11 |
| NFE2L1 | SERPINF2 | 0.719596 | 3 | 0 | 3 |
| NFE2L1 | SP4 | 0.719018 | 4 | 0 | 4 |
| NFE2L1 | PLOD3 | 0.718945 | 11 | 0 | 11 |
| NFE2L1 | TTC7B | 0.718472 | 7 | 0 | 7 |
| NFE2L1 | SERPINH1 | 0.718333 | 10 | 0 | 9 |
For details and further investigation, click here
