SMARCA4

 

Full name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 Alias Symbol: hSNF2b|BRG1|BAF190|SNF2|SWI2|SNF2-BETA|SNF2LB|FLJ39786
Type: protein-coding gene Cytoband: 19p13.2
Entrez ID: 6597 HGNC ID: HGNC:11100 Ensembl Gene: ENSG00000127616 OMIM ID: 603254
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 25/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of SMARCA4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SMARCA4 6597 208794_s_at -0.0014 0.9990
GSE20347 SMARCA4 6597 208794_s_at -0.4187 0.0041
GSE23400 SMARCA4 6597 214728_x_at 0.0596 0.4963
GSE26886 SMARCA4 6597 208794_s_at 0.3510 0.1724
GSE29001 SMARCA4 6597 213720_s_at -0.2974 0.3863
GSE38129 SMARCA4 6597 208794_s_at -0.0429 0.8233
GSE45670 SMARCA4 6597 208794_s_at 0.0403 0.7985
GSE63941 SMARCA4 6597 208794_s_at -0.1711 0.7668
GSE77861 SMARCA4 6597 208794_s_at -0.0447 0.8499
GSE97050 SMARCA4 6597 A_23_P39034 -0.1898 0.6358
SRP007169 SMARCA4 6597 RNAseq -0.1669 0.6885
SRP008496 SMARCA4 6597 RNAseq -0.3669 0.2499
SRP064894 SMARCA4 6597 RNAseq -0.1354 0.5428
SRP133303 SMARCA4 6597 RNAseq -0.3615 0.0348
SRP159526 SMARCA4 6597 RNAseq -0.1070 0.7331
SRP193095 SMARCA4 6597 RNAseq -0.2034 0.1194
SRP219564 SMARCA4 6597 RNAseq 0.0599 0.8902
TCGA SMARCA4 6597 RNAseq 0.1105 0.0161

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by SMARCA4 expression:

 

TCGA

 

Note: Click image to view full size file.  

Copy number change of SMARCA4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SMARCA4 6597 4 2 24
GSE20123 SMARCA4 6597 3 1 26
GSE43470 SMARCA4 6597 2 6 35
GSE46452 SMARCA4 6597 47 1 11
GSE47630 SMARCA4 6597 4 7 29
GSE54993 SMARCA4 6597 16 3 51
GSE54994 SMARCA4 6597 6 13 34
GSE60625 SMARCA4 6597 9 0 2
GSE74703 SMARCA4 6597 2 4 30
GSE74704 SMARCA4 6597 0 1 19
TCGA SMARCA4 6597 16 15 65

Total number of gains: 109; Total number of losses: 53; Total Number of normals: 326.  

 

Somatic mutations of SMARCA4:

 

Generating mutation plots.

 

Highly correlated genes for SMARCA4:

 

Showing top 20/345 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SMARCA4CAPZB0.823356303
SMARCA4TET20.754487303
SMARCA4ZNF7660.735958303
SMARCA4PROSER10.724976303
SMARCA4HMGN10.724963404
SMARCA4SEC31A0.715338303
SMARCA4MRPS18A0.71377303
SMARCA4MTF10.708863404
SMARCA4PAN30.706942303
SMARCA4ZFP620.702077303
SMARCA4ZNF2660.690328303
SMARCA4UBE2L30.689981403
SMARCA4TRIM380.688538303
SMARCA4USP40.687727303
SMARCA4ATP6V1A0.686143303
SMARCA4RAP1GDS10.681794404
SMARCA4NARF0.676343303
SMARCA4TNKS20.669034403
SMARCA4POLR2I0.668156303
SMARCA4HK10.667902303

For details and further investigation, click here